http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Abdel Latif, Fathy Fahim The Pharmaceutical Society of Korea 1989 Archives of Pharmacal Research Vol.12 No.4
Synthesis of spiro 1, 4-dihydropyridines by a novel and facile one step method is reported. Structures and reaction are also reported with a support by another synthetic routes.
Abdel-Latif, F.F.,Ahmed, E.Kh.,Mekheimer, R.,Mashaly, M.M. The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.5
Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanisms were reported and supported via a second synthetic route.
Mona Abdel Latif Alsayed,Shymaa Mohsen Elbeah,Manal M. El-Desoky,Shereen Magdy Elziny,Ahmed Megahed 대한소아소화기영양학회 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.1
Purpose: Autoimmune hepatitis (AIH) is a chronic disease that may lead to cirrhosis. The immunopathogenesis of AIH is not fully understood and it mainly involves T-cell mediated mechanism. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that promotes T cell response and its polymorphism may serve as a severity marker of AIH. No previous study has considered investigating MIF polymorphism in children with AIH. Methods: Forty-two children with definite diagnosis of AIH were enrolled along with 100 age and sex matched controls. All participants were tested for polymorphism at -173GC (rs755622) of MIF gene. All patients received the standard protocol of steroid plus azathioprine to achieve remission. Liver biopsy was performed at time of diagnosis for all patients and only 18 of them underwent a second biopsy after treatment. Results: No statistically significant differences in the frequency of the genotypes GG and GC or in allele distribution were found in both patient and control groups (p=0.590, 0.640 respectively). Initial alanine aminotransferase (ALT) levels at the time of presentation was significantly higher in the GC group than GG group (p=0.020). GC genotype significantly correlated with disease relapse (r=0.41, p=0.007). Regression of necroinflammation and the fibrosis score in the second liver biopsy was statistically significant in the GG group (p<0.0001, p=0.010 respectively). Conclusion: MIF -173GC polymorphism is associated with clinically significant markers of pediatric AIH, including increased initial serum ALT levels, may help predict necroinflammatory/fibrosis regression effectively, following immunosuppressive treatment.
Khaled Y. Abdel-Halim,Elsayed I. Salim,Ahmed S. Abdel-Latif,Sally E. Abu-Risha 환경독성보건학회 2023 환경독성보건학회지 Vol.38 No.4
A quantitative assessment of silver nanoparticles (AgNPs) in fluids and some organs of pregnant rats as well as their fetal blood were carried out in this study. A single oral dose (1mg/kg) of AgNPs with a size range of 4-20 nm was administered to pregnant rats on the 19th of gestation. Five groups were euthanized after 10 min, 1, 6, 12, and 24 hr as well as the control group. Total Silver (Ag) contents were measured in bloods (maternal and fetal) and several organs using Inductive Coupled Plasma Optical Emission Spectroscopy (ICP-OES) followed by acid digestion. In maternal blood, AgNPs were found to increase time-dependently after 12 and 24 hr into 0.135 and 0.224 μg/ml, but it was slightly higher in fetal blood (0.32 and 0.31 μg/ml) after 10 min and 1 hr. In other samples: kidneys, liver, spleen, placenta, and uterus the data indicated that NPs were rapidly absorbed from the dosing site (gastrointestinal tract) as evidenced by the detection of Ag in the analyzed samples (fluids and tissues). On the other hand, the cumulative percentages of excretion level in urine was 8.25% which was higher than in feces (4.77%) after 24 hr. These findings indicate the ability of AgNPs to accumulate in pregnant rats and transfer to their fetus imposing adverse outcomes and male formation. Thus, further investigations must be followed for direct and/or indirect exposure to such NPs before decision for their practices.
Rania G. Abdel-latif,Rehab A. Rifaai,Entesar F. Amin 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.5
Ischemic stroke is a serious condition associatedwith severe functional disability and high mortality,however; eff ective therapy remains elusive. Empaglifl ozin,a sodium-glucose cotransporter 2 inhibitor, has been shownto exert additional non-glycemic benefi ts including antiapoptoticeff ects in diff erent disease settings. Thereby, thisstudy was designed to investigate the ameliorative eff ect ofempaglifl ozin on the neuronal apoptosis exhibited in cerebralischemia/reperfusion (I/R) in a rat model targetingHIF-1α/VEGF signaling which is involved in this insult. Global cerebral I/R injury was induced in male Wistar ratsthrough occlusion of the bilateral common carotid arteriesfor 30 min followed by one-hour reperfusion. Empaglifl ozindoses of 1 and 10 mg/kg were administered 1 and 24 h afterreperfusion. In I/R-injured rats, empaglifl ozin treatmentssignifi cantly reduced infarct size and enhanced neurobehavioralfunctions in a dose-dependent manner. The drugalleviated neuronal death and cerebral injury infl icted byglobal ischemia as it suppressed neuronal caspase-3 proteinexpression. In parallel, protein expressions of HIF-1αand its downstream mediator VEGF were upregulated inthe ischemic brain following empaglifl ozin treatment. Theresults indicated that empaglifl ozin attenuates cerebral I/Rinducedneuronal death via the HIF-1α/VEGF cascade.
Alsayed, Mona Abdel Latif,Elbeah, Shymaa Mohsen,El-Desoky, Manal M.,Elziny, Shereen Magdy,Megahed, Ahmed The Korean Society of Pediatric Gastroenterology 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.1
Purpose: Autoimmune hepatitis (AIH) is a chronic disease that may lead to cirrhosis. The immunopathogenesis of AIH is not fully understood and it mainly involves T-cell mediated mechanism. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that promotes T cell response and its polymorphism may serve as a severity marker of AIH. No previous study has considered investigating MIF polymorphism in children with AIH. Methods: Forty-two children with definite diagnosis of AIH were enrolled along with 100 age and sex matched controls. All participants were tested for polymorphism at -173GC (rs755622) of MIF gene. All patients received the standard protocol of steroid plus azathioprine to achieve remission. Liver biopsy was performed at time of diagnosis for all patients and only 18 of them underwent a second biopsy after treatment. Results: No statistically significant differences in the frequency of the genotypes GG and GC or in allele distribution were found in both patient and control groups (p=0.590, 0.640 respectively). Initial alanine aminotransferase (ALT) levels at the time of presentation was significantly higher in the GC group than GG group (p=0.020). GC genotype significantly correlated with disease relapse (r=0.41, p=0.007). Regression of necroinflammation and the fibrosis score in the second liver biopsy was statistically significant in the GG group (p<0.0001, p=0.010 respectively). Conclusion: MIF -173GC polymorphism is associated with clinically significant markers of pediatric AIH, including increased initial serum ALT levels, may help predict necroinflammatory/fibrosis regression effectively, following immunosuppressive treatment.
Seismic pounding effects on adjacent buildings in series with different alignment configurations
Shehata E. Abdel Raheem,Mohamed Y.M. Fooly,Aly G.A. Abdel Shafy,Yousef A. Abbas,Mohamed Omar,Mohamed M.S. Abdel Latif,Sayed Mahmoud 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.28 No.3
Numerous urban seismic vulnerability studies have recognized pounding as one of the main risks due to the restricted separation distance between neighboring structures. The pounding effects on the adjacent buildings could extend from slight non-structural to serious structural damage that could even head to a total collapse of buildings. Therefore, an assessment of the seismic pounding hazard to the adjacent buildings is superficial in future building code calibrations. Thus, this study targets are to draw useful recommendations and set up guidelines for potential pounding damage evaluation for code calibration through a numerical simulation approach for the evaluation of the pounding risks on adjacent buildings. A numerical simulation is formulated to estimate the seismic pounding effects on the seismic response demands of adjacent buildings for different design parameters that include: number of stories, separation distances; alignment configurations, and then compared with nominal model without pounding. Based on the obtained results, it has been concluded that the severity of the pounding effects depends on the dynamic characteristics of the adjacent buildings and the input excitation characteristics, and whether the building is exposed to one or two-sided impacts. Seismic pounding among adjacent buildings produces greater acceleration and shear force response demands at different story levels compared to the no pounding case response demands.
Synthesis and Antiviral Activity of 3-Aminoindole Nucleosides of 2-Acetamido-2-deoxy-D-glucose
Abdel-Rahman, Adel A.H.,El-Latif, Mona M. Abd,El-Essawy, Farag A.,Barakat, Yousif A. Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.10
A new method for the construction of 3-aminoindole nucleosides of 2-acetamido-2-deoxy-D-glucose based is presented. Nitration and acetylation of the indole nucleosides by acetic anhydride-nitric acid mixture followed by reduction using silver catalyst (SNSM) impregnated on silica gel, afforded the corresponding amino indole nucleosides. The nucleosides were tested for antiviral activity against hepatitis B virus (HBV) to show different degrees of antiviral activities or inhibitory actions.
Blind Audio Watermarking Technique Based on Two Dimensional Cellular Automata
Hazem Hiary,Abdel Latif Abu Dalhoum,Alia Madain,Alfonso Ortega,Manuel Alfonseca 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.9
In this paper we propose a new method of digital audio watermarking based on two dimensional cellular automata; the method increases the dimension of the audio and uses cellular automata in generating the key of watermark embedding. The watermarking method is blind, and does not require the original host audio or any of its features to extract the watermark; the watermark can be easily extracted using the right key. The experimental results show that the watermarks are imperceptible; and show a high similarity between the original and the watermarked audio. Cosine similarity and peak signal-to-noise ratio were used to measure the similarity between the original audio and the watermarked audio.