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Inhibitory Effects of Thymol Isolated from Curcuma longa L. on Adipogenesis in HepG2 Cells
Dam Hee Kang(강담희),Young Seob Lee(이영섭),Seon Min Oh(오선민),Da Hye Yoon(윤다혜),Doo Jin Choi(최두진),Dae Young Lee(이대영),Kyung Sook Han(한경숙),Geum Soog Kim(김금숙),Dong Hwi Kim(김동휘),Dong Yeul Kwon(권동열),Ok Hwa Kang(강옥 한국약용작물학회 2020 한국약용작물학회 학술대회논문집 Vol.2020 No.1
황흑산(黃黑散)의 메티실린 내성 황색포도상구균에 대한 항균 활성과 옥사실린과의 시너지 효과
최성훈 ( Sung-hoon Choi ),강옥화 ( Ok-hua Kang ),주전 ( Tian Zhou ),공룡 ( Ryong Kong ),이승진 ( Seung-jin Lee ),강담희 ( Dam-hee Kang ),정혜인 ( Hye-in Jung ),이영섭 ( Young-seob Lee ),권동렬 ( Dong-yeul Kwon ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.5
Objectives : Hwangheuk-san is a complex prescription composed of oriental traditional medicine and has been reported for antioxidant, antimicrobial and anticancer effects in the recent study. Methicillin-resistant Staphylococcus aureus (MRSA) is one of important causes of fatal infectious diseases such as septicemia, endocarditis, toxic shock syndrome, pneumonia, skin and soft tissue infections (SSTIs). S. aureus is reported as being for a variety of human diseases and its epidemiological relevance is mainly due to their ability of becoming highly resistant to common antimicrobials such as tetracycline, penicillin, cphalosporin and aminoglycoside. The objective of this study is to determine the antimicrobial effect of Hwangheuk-san ethanol extracts (HHS) and synergistic effects with antibiotics oxacillin against MRSA. Methods : The antimicrobial activity of HHS was measured by the disc diffusion method, broth microdilution method and the checkerboard dilution test, time-kill curve assay was performed to investigate synergistic effects with antibiotics oxacillin against MRSA. Results : HHS showed antimicrobial activity against MRSA with a MIC value of 125 ㎍/㎖. In the checkerboard test, the interaction of HHS with antibiotics oxacillin produced almost synergy or partial synergy against MRSA. This study showed that HHS reduced the MICs of oxacillin tested, and a remarkable antibacterial effect of HHS, with membrane permeability enhancers. Conclusions : These results suggest that HHS has the antimicrobial effect and synergistic effects with antibiotics oxacillin against MRSA. This study thus can be a valuable source for the development of a new drug with low MRSA resistance.
산사의 NAFLD 보호 효과 및 그 작용기전에 관한 연구
김민철 ( Min-chul Kim ),공룡 ( Ryong Kong ),한형선 ( Hyoung-sun Han ),강담희 ( Dam-hee Kang ),이승진 ( Seung-jin Lee ),이천천 ( Cheon-cheon Lee ),왕서 ( Seo Wang ),권동렬 ( Dong-yeul Kwon ),강옥화 ( Ok-hwa Kang ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.6
Objectives : Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of hepatic triglycerides (TG) that leads to inflammation and fibrosis. Crataegi Fructus ethanol extract (CE) is a korean traditional herb that used for digestive diseases. It has been investigated that CE has the effect that prevent hepatotoxicity caused by CCl4 or GaIN and regulate the inflammatory in several organs. However, a hypolipidemic effect of CF has not been reported. Methods : The purpose of this study is that examine the lipid accumulation inhibitory effect of CE on NAFLD. We checked the body and liver weight change of MCD-diet induced mice with/without administration of CE. The blood lipid levels of C57BL/6J mice were checked by biochemistry. Also we observed the liver histology of MCD-diet induced mice and investigate the molecular mechanisms in MCD-diet-induced NAFLD in C57BL/6J mice. Results : CE improved MCD-diet-induced lipid accumulation and TG and TC levels. Also, CE decreased hepatic lipogenesis such as SREBP-1, C/EBPα, PPARγ, ACC and FAS. Besides, we also found out that CE increased AMPK phosphorylation. These results indicated that CE has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability. Conclusions : In this report, we found CE exerted a regulatory effect on lipid accumulation by decreasing lipogenesis in MCD-diet induced NAFLD model. Therefore, CE extract may be active in the prevention of fatty liver.