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백준오 ( Jun Oh Paek ),이정우 ( Jung Woo Lee ),박경태 ( Kyoung Tae Par ),유희준 ( Hee Joon Yu ),김정수 ( Jung Soo Kim ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.5
Neutrophilic dermatosis of the dorsal hands (NDDH) is a recently described skin disorder regarded as a localized variant of acute febrile neutrophilic dermatosis (Sweet syndrome). The lesions of NDDH are characterized by erythematous plaques, pustules, and hemorrhagic bullae on the dorsal surface of the hands. Herein, we report a case of NDDH in a 52-year-old man with concomitant involvement of the ankle. The patient presented with well-demarcated erythematous papules, patches, and plaques on the dorsum of the hands as well as erythematous papules on the left ankle for 3 days. The lesions responded rapidly to systemic corticosteroid therapy. (Korean J Dermatol 2011;49(5):487∼490)
최성준(Sung Jun Choi),유희준(Hee Joon Yu),손숙자(Sook Ja Sohn) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.4
We observed 17 cases of cafe au lait spots histopathplogi ally. Out of 17 cases, 9 cases were neurofibromatosis with neurofibromas, 6 cases were neurofibromatosis without neurofibroma, and 2 cases were normal healthy persons. The results were as follows. l. In all 17 cases, melanin pigment was increased in melanocytes and keratinocytes. 2. Griant pigment granules were identified only in 3 cases of neurofibromatosis with neurofibromas.
최성준(Sung Jun Choi),유희준(Hee Joon Yu),손숙자(Sook Ja Sohn) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.3
We observed clinical and histopathological findings of porokeratosis in 16 cases which comprised 2 linear types, 4 superficial disseminat:ed forms, 4 disseminated superficial actinic porokeratosis and 6 plaque types. From the observation, the following results were obtained. l. Clinical results 1) Eleven cases were men, 5 cases were women, and the sex ratio was 2. 2 to 1, age distribution was from 6 to 61 years (mean age: 34. 2years), and the distribution of age of onsets was from 2 to 52 years(mean age of onset' 23. lyears). 2) Four cases had family history of porokeratosis, but linear forms did not. 3) Nine cases had pruritus especially, all cases of DSAP and DSP except 1 case complained pruritus. 4) Tmo cases of DSAP had tendency of summer exacerbations. 2. Histopathological results 1) Cornoid lamellae were prominent in all cases of plaque types and linear types, and minimal in all cases of DSAP and DSP except 1 case. 2) Epidermis between the cornoid lamellae were normal or acanthotic in all cases except 1 case of plaque types and linear types, and were atrophic in 5 cases of 8 cases in DSAP and DSP.
최성준(Sung Jun Choi),김광수(Kwang Soo Kim),유희준(Hee Joon Yu),손숙자(Sook Ja Sohn) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.4
We report a case of Waardenburgs syndrome in 18-year-old male patient who has total deafness of the right ear, heterochromia irides, hypopigmented patches on the face and trunk, and disseminated lentigines on the entire body surface since birth. His 51-year-old mother also has total deafness, heterochromia irides, white foreloek, and disseminated lentigines on the entire body surface. The patient with this disorder may complain of pigmentary abnormalities, and we believe dermatologists should pay more attention to systemic signs of the congen:ital pigmentary disorders.
강호송 ( Ho Song Kang ),백준오 ( Jun Oh Paek ),박경태 ( Kyung Tae Park ),김정수 ( Joung Soo Kim ),유희준 ( Hee Joon Yu ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.1
Lichen planus is a chronic papulosquamous disease that affects the skin and mucous membranes. It is characterized by pruritic violaceous papules that are most commonly seen on the extremities of middle aged adults, but the elderly are rarely affected. Hypertrophic lichen planus usually occurs on the extremities and especially on the shins, and it tends to be the most pruritic variant. An 82-year-old female presented with severe pruritic multiple papules and plaques on the both the upper and lower extremities for 1 year. At first, the lesions began as small, polygonal papules that formed verrucous plaques over several months. Histopathologic examination showed marked hyperkeratosis, irregular acanthosis and wedge-shaped hypergranulosis. The vacuolar alteration and the lymphocytic inflammatory infiltrate were accentuated at the base of the rete ridge. From these findings, we diagnosed these lesions as hypertrophic lichen planus. The lesions were treated with topical steroid and intralesional injection of steroid, and they were slightly improved after 2 months of therapy. (Korean J Dermatol 2011;49(1):82~85)
수두와 대상포진 환자에서 수두대상포진 바이러스에 대한 혈청 내 면역글로불린 M, G의 임상적 의의
김영균 ( Young Gyun Kim ),백준오 ( Jun Oh Paek ),김정수 ( Joung Soo Kim ),유희준 ( Hee Joon Yu ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.6
Background: The presence of serum varicella zoster virus (VZV) immunoglobulin M and G (IgM and IgG) aid diagnosis of and confirmation of immunization against varicella and herpes zoster. However, the relationship between serum VZV IgM and IgG and the clinical characteristics of VZV infection remains unclear. Objective: We evaluated quantitative changes in serum VZV IgM and IgG in accordance with the clinical features of varicella, herpes zoster, and disseminated herpes zoster compared with a normal control group. Methods: A total of 922 patients were classified into 3 groups: varicella, herpes zoster, and disseminated herpes zoster. We assessed serum VZV IgM and IgG titers in association with age, severity of skin lesions, duration of skin lesions, immune status, and neurologic complications. Results: In patients with varicella and herpes zoster, serum antibody titer varied significantly depending on age and the duration of skin lesions. A high serum VZV IgM titer was related to varicella or disseminated herpes zoster viremia. In herpes zoster, elevated antibody titers, especially VZV IgM, were associated with severe skin lesions and the presence of neurologic complications. Conclusion: Serologic data for varicella and herpes zoster varied according to clinical features. A high serum VZV IgM titer was associated with an unfavorable clinical course of herpes zoster. (Korean J Dermatol 2015;53(6):441∼ 448)
전형적인 가와사키병 환아와 경부 림프절종대를 주소로 내원하여 가와사키병으로 진단된 환아의 비교
윤혜원 ( Hye Won Yun ),이준열 ( Jun Yeol Lee ),양송이 ( Song I Yang ),유희준 ( Hee Joon Yu ),강민재 ( Min Jae Kang ),이소연 ( So Yeon Lee ),이혜란 ( Hae Ran Lee ),김광남 ( Kwang Nam Kim ),김성혜 ( Sung Hye Kim ) 대한소아감염학회 2016 Pediatric Infection and Vaccine Vol.23 No.1
목적: 가와사키병은 임상적인 증상에 의존하여 진단하므로 조기진단이 어려우며 특히 경부 림프절종대 만을 주소로 내원할 경우 가와사키병의 진단에 어려움을 줄 수 있다. 본 연구는 전형적인 양상의 가와사 키병 환아와 발열과 경부 림프절종대를 주 증상으로 내원한 가와사키병 환아에서의 임상적 차이와 진단의 지연 및 관상동맥 합병증과의 연관성을 확인하고자 하였다. 방법: 2012년 1월부터 2014년 12월까지 한림대학교성심병원에 가와사키병으로 입원한 환자 중 전형 적인 임상증상으로 내원하여 가와사키병으로 진단받은 259명을 대조군(KD 군)으로, 발열과 경부 림프 절종대를 주 증상으로 내원하여 가와사키병으로 진단받은 24명을 환자군(LKD 군)으로 정하여 후향적 으로 조사하였다. 결과: LKD 군의 평균연령은 40개월로 KD 군의 28개월보다 높았다(P=0.04). 발열부터 가와사키병으로 진단받고 정맥용 면역글로불린 치료를 하기까지의 기간은 LKD 군에서 KD 군에 비해 더 길었다(P< 0.001). 발열을 제외한 다섯 가지 임상 증상 중 LKD 군에서는 평균 1.62개, KD 군에서는 평균 3.47 개의 증상을 보여 통계적으로 유의한 차이를 보였다(P<0.001). LKD 군에서 혈액검사 상 C-반응단백이 KD 군에 비해 높았다(P=0.01). 진단 2주 이내와 2개월 이내에 시행한 심장 초음파 검사에서 관상 동맥 합병증 발병률은 두 군에서 차이가 없었다(P=0.52, P=0.08). 결론: 발열과 경부 림프절종대를 주 증상으로 내원하는 경우 가와사키병의 임상양상이 뚜렷하지 않아 초기에 진단하기 어려우므로 진단이 지연되지 않도록 환자 진찰 시 세심한 관찰이 필요하다. Purpose: The diagnosis of Kawasaki disease depends on clinical symptoms, which makes it difficult to diagnose early in patients with only cervical lymphadenopathy. The purpose of this study is to understand the clinical characteristics of cervical-lymph-node-first presentation of Kawasaki disease and compare them with those of typical Kawasaki disease. Methods: We surveyed 283 patients who were admitted to Hallym Sacred Heart Hospital and were diagnosed with Kawasaki disease from January 2012 to December 2014. The patients were divided into two groups: cervical-lymph-node-first presentation of Kawasaki disease (LKD, N=24) and typical Kawasaki disease (KD, N=259). The medical records were retrospectively reviewed. Results: The mean age of the LKD group was higher than that of the KD group (P=0.04). At admission, the LKD patients had on average 1.62 out of 5 symptoms, whereas the KD patients had 3.47. The time from fever to diagnosis and administration of IV immunoglobulin was longer in the LKD group than in the KD group (P<0.001). The mean C-reactive protein of the LKD group was higher than that of the KD group (P= 0.01). There were no statistical differences in the presence of coronary artery complications between the two groups at two weeks or at two months after diagnosis (P=0.52, P=0.08). Conclusions: The Kawasaki disease patients with fever and cervical lymphadenopathy usually do not present obvious clinical symptoms, which makes it hard to diagnose in the early phase of disease. Clinician must pay attention when examining these patients.
이혜영(Hae Yung Lee),최성준(Sung Jun Choi),유희준(Hee Joon Yu),손숙자(Sook Ja Son) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.3
We reported a case of cutaneous focal mucinosis in a 19 year-old male, which occured by multiple nodules on the both dorsa of hands, extensor surface of elbows, intergluteal folds and shins, and responded well to intralesional injection of triamcinolon acetonide. Histopathologically, most of the collagen in the dermis is replaced to homogeneous mucinous material which was confirmed as hyaluronic acid.
김현우 ( Hyun Woo Kim ),백준오 ( Jun Oh Paek ),강호송 ( Ho Song Kang ),김정수 ( Joung Soo Kim ),유희준 ( Hee Joon Yu ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.11
Glomus tumors are benign cutaneous neoplasm, occurring in the vascular hamartomatous tubercles of the glomus body, which is a myoarterial apparatus typically found in the reticular dermis of the skin. Histopathologically, glomus tumors are composed of neoplastic cells that resemble normal glomus cells, arranged around a varying number of thin-walled, sometimes branching capillaries. Immunohistochemically, neoplastic cells in glomus tumors clearly exhibit smooth muscle characteristics with expression of muscle-specific actin and α-smooth muscle actin; whereas, the expression of CD34 is rare. In this report, we present two cases of benign glomus tumors on the subungual area and palm. Tumor cells of glomus tumor in two patients were both positive for smooth muscle actin (SMA) and CD34 immunohistochemical staining. We thought that coexpression of SMA and CD34 adds support to the interpretation of these lesions as a family of perivascular neoplasms. (Korean J Dermatol 2012;50(11):969∼ 973)