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임신토끼에 있어서 새로운 Recombinant Human Granulocyte Colony - Stimulating Factor ( YHB6211 ) 의 배 , 태자 발생독성평가
황재식(Zai Zhi Huang),이수해(Su Hae Lee),신지순(Ji Soon Sin),신장우(Jang Woo Sin),최연식(Yeon Shik Choi),김대중(Dae Joong Kim),장호송(Hu Song Zhang),정은용(Eun Yong Jung),서동석(Dong Suk Seo),안경규(Kyoung Kyu Ahn),남상윤(Sang Yoon N 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.4
N/A YHB6211, a newly developed recombinant human granulocyte colonystimulating factor, was administered at dose levels of 0, 3, 15, and 75 ㎍/㎏/day intravenously to the pregnant New Zealand White rabbits (20 rabbits per group) during the organogenetic period, days 6 to 18 of gestation. All dams were subjected to Caesarian section on day 28 of gestation and their fetuses were examined for external, visceral, and skeletal abnormalities. No abnormalities in clinical signs, body weight changes, gross findings, mortality, and external appearance were found in all dams and fetuses exposed to 0, 3, and 15 ㎍/㎏/day of YHB6211. However, in the group treated with 75 ㎍/㎏/day of YHB6211, maternal body and uterine weights, fetal body weights and length, and the number of live fetuses were significantly decreased and further fetal mortality was remarkably increased. It is suggested that YHB6211 may have no side effect up to the dose level of 15 ㎍/㎏/day, and there would be no teratogenicity for fetuses of rabbits up to 75 ㎍/㎏/day even if it may have some toxic effects over 75 ㎍/㎏/day for dams and fetuses of rabbits.
Physostigmine과 procyclidine으로 구성된 유기인제 중독 복합예방제에 대한 2주 반복투여 용량설정시험
황재식(Zai-Zhi Huang),강현구(Hyun-Gu Kang),박선희(Sun-Hee Park),강성귀(Seong-kwi Kang),이종성(Jong-Sung Lee),박종일(Jong-Il Park),김왕수(Wang-Soo Kim),피택산(Taek-San Phi),황석연(Seok-Yeon Hwang),강종구(Jong-Koo Kang),김윤배(Yun-Bae 한국실험동물학회 2003 Laboratory Animal Research Vol.19 No.4
Physostigmine과 procyclidine으로 구성된 유기인제 중독 복합예방제에 대한 4주 반복투여 독성평가
이종성(Jong-Sung Lee),황재식(Zai-Zhi Huang),강현구(Hyun-Gu Kang),박선희(Sun-Hee Park),박철범(Cheol-Beom Park),박종일(Jong-Il Park),김왕수(Wang-Soo Kim),피택산(Taek-San Phi),최은경(Ehn-Kyoung Choi),황석연(Seock-Yeon Hwang),강종구(Jong 한국실험동물학회 2003 Laboratory Animal Research Vol.19 No.4
새로운 간질환치료제(고덱스 : 헤파디프에스)의 랫드에 대한 4주반복투여 경구독성시험
강종구(Jong-Kii Kang),정은용(Eun-Yong Jung),박선희(Sun-Hee Park),김선희(Sun-Hee Kim),이수해(Su-Hae Lee),장호송(Hu-Song Zhang),황재식(Zai-Zhi Huang),남상윤(Sang-Yoon Nam) 한국독성학회 2001 Toxicological Research Vol.17 No.2
This study was designed to evaluate a repeated oral dose toxicity of a new hepatotherapeutic agent GODEX in Sprague-Dawley rats. Male and female rats were orally administered with dosages of 500, 100, 20, and a mg/kg/day of GODEX daily for 4 weeks, respectively. There were no dose-related changes in clinical signs, body weight changes, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with GODEX. Gross and histopathological findings revealed no evidence of specific toxicity related to GODEX. These indicate that GODEX may have no side effects and its oral maximum tolerated dose value may be over 500 mg/kg in rats.