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황의완(Wei Wan Whang),김종우(Jong Woo Kim),이조희(Jo Hee Lee),엄효진(Hyo Jin Eom),이승기(Seung Gi Lee) 대한한방신경정신과학회 1996 동의신경정신과학회지 Vol.7 No.1
N/A 1. Out of 21 examples on a clinical base Alzheimer type dementia were 8 examples(38%), 11 vascular types(52%), 1 Alzheimer and vascular mixed type and rest 1 was secondary dementia type(NPH). 2. Between the gendes, there were 5 males and 3 females for Alzheimer types, 6 males and 5 females for the vascular types, 1 male for Alzhrimer and vascular mixed type, and 1 frmale for secondary dementia type(NPH). 3. For the degrees of Alzheimer type dementia there were 2 mild dementia, 4 moderate dementia, and 2 severe dementia. 4. Among the Alzheimer types 2 mild dementia were almost recovered back to normal in approximately 2 months, 2of 4 moderate dementia became significantly better in approximately 2 months and recovered to almost normal state in 3 to 5 months. The rest 2 have been under treatment for 3 months, but showed a little improvement. Out of 2 severe dementia examples, one showed a little improvement even if it has been under treatment over 2 years. The other exampe did not show any improvement, but dementia did not proceed any more. 5. Among the 11 vascular examples, 7 recovered in 2 to 3 months, 1 in 5 months, 2 recovered in a year, and the treatment was stopped arbitrary for the last one. 6 In the case of Alzheimer and vascular mixed type dementia, even the moderate dementia did not show any apparent result in 6 months. 7. For NPHI (Normal Pressure Hydrocephalus), there was an improvement on dementia in 2 months after the treatment, but gait disturbance and urinary incontinence did not show any noticeable difference. As a conclusion, almost all the Alzheimer and vascular type patients recovered, but the treatment periods varied depending on the types of the dementia and the degree of seriousness, especially in the case of the severe Alzheimer patients, the treatment oniy suppression the progression of the dementia. The most important aspect from clinical point of view was even if almost all the patients were almost completely cired, they need to keep being cured for a long period of time. The methol with respect to Four Constitutions is thought of the most desirable.
청화보심탕(淸火補心湯)이 우울증(憂鬱症) 막형동물(模型動物)의 절망행동(絶望行動), 불안(不安) 및 뇌(腦)의 TH 와 c-Fos 발현(發展)에 미치는 효과(效果)
조충훈,신현규,황의완,Cho, Chung-Hoon,Shin, Hyeun-Kyoo,Whang, Wei-Wan 한국한의학연구원 2003 한국한의학연구원논문집 Vol.9 No.1
Objective : This study was designed to assess the protective effects of Chengwhabosimtang on the animal model of depression, chronic mild stress(CMS). Method : Male Sprague-Dawley rats Were used for this experiment. The subjects Were divided into 3 groups (1. CMS-drug: Chengwhabosimtang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment they were executed Forced swimming test(FST) and Elevated plus maze. Tyrosine hydroxylase(TH) in ventral tegmental area(VTA) and c-Fos in paraventricular nucleus(PVN) were measured. Result : 1. In FST, CMS-drug group showed significantly decreased immobility behavior. 2. CMS-drug group showed no significantly lower TH level in VTA than CMS-vehicle group. 3. CMS-drug group showed significantly less c-Fos expressed cell bodies in PVN than CMS-vehicle group. 4. In Elevated plus maze, CMS-drug group showed no significantly anxiety. Conclusion : These results suggest that Chengwhabosimtang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus and dopaminergic neurons in VTA.
소아(小兒)의 행동양식(行動樣式)과 소증(素症)의 관련성(關聯性)에 관한 탐색적(探索的) 연구(硏究)
김명근 ( Myoung Geun Kim ),황의완 ( Wei Wan Whang ),김종우 ( Jong Woo Kim ) 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.2
Objective : This study was designed for find corelation between behavior and physical symptoms in child. Physical symptoms appearing related with weak viscera are selected. And behaviors related to selected symptoms are compared that of children with character type defined by Jung, C. G. Method : 497 children ( 3-11 years old ) who have visited two oriental clinic ( one is in Gang-Nam Gu Seoul (282 children), the other is in Joong-Rang Gu Seoul (215 children) ) from Jan. to Jul. 2006 were invested through the questionnaires, which were filled by their parents. These questionnaires have 61 yes-no type questions about behaviors on 12 situations, 36 yes-no type questions about physical symptoms in 15 categories. 6 questions expected positive answer in child with weak spleen are categorized sp-q and 6 related weak lung, lu-q, 6 related weak kidney, ki-q. Numbers of positive answers in sp-q, lu-q and ki-q are counted sp-index, lu-index and ki-index each. Corelation between behavior questions and 3 symptom indexes are measured and questions shown low significance level ( under 5% in pearson corelation, two-tailed ) are selected. Result : 15 behaviors related sp-index, 12 related lu-index, 12 related ki-index are selected and analysed. Conclusion : 1. Behaviors related sp-index is similar to that of Thinking Type children Grouped by Jung, C. G.. 2. Behaviors related lu-index is similar to that of Sensation Type. 3. Behaviors related sp-index is similar to that of Feeling Type.