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T2DM 노화 쥐에서 운동 강도에 따른 지구력 운동이 Autophagy와 인슐린 저항성의 개선효과.
황은아(Hwang, Eun-A),하태균(Ha, Tae-Geun) 한국레저사이언스학회 2021 한국레저사이언스학회지 Vol.12 No.2
본 연구는 T2DM 노화 쥐에서 운동 강도에 따른 지구력 운동이 Autophagy와 인슐린 저항성 개선효과를 알아보고자 하였다. T2DM은 고지방식이 섭취와 streptozotocin(STZ; 40mg/kg)을 투여하여 공복혈당이 300mg/dl이상일 때 당뇨병이 유도된 것으로 분류하였으며, 그룹은 총 40마리 4개 그룹으로 대조군(n=10), 저강도 운동군(n=10), 중강도운동군(n=10), 고강도 운동군(n=10) 분류하였다. 훈련은 설치류 VO2max의 약 저강도(40%), 중강도(60%) 그리고 고강도(80%)인 9∼26m/min의 속도와 경사 10˚의 경사도에서 8주간(60분/5일/주)의 훈련을 실시하였다. Gastrocnemius에서 단백질을 추출하였고, Western blotting을 이용하여 인슐린관련인자(GLUT4, PGC-1α)와 Autophagy 관련인자(Beclin-1, ATG7)를 분석하였다. 결과는 인슐린과 Autophagy관련인자에서는 모두 운동집단에서 유의하게 증가를 보였으며, 중강도 운동집단에서 가장 높은 발현을 나타냈다. 이러한 결과들을 종합해보면 T2DM노화 쥐를 대상으로 운동의 효과로서 혈당개선과 함께 autophagy의 발현을 증가함으로서 세포항상성과 관련된 긍정적인 효과를 나타낼 것으로 생각된다. The purpose of this study was to investigate the effects of endurance exercise on exercise strength on improving autophagy and insulin resistance in aging T2DM rats. T2DM was classified as type 2 diabetes induced when blood sugar was more than 300 mg/dl with high fat diet and streptozotocin(STZ; 40 mg/kg), with a total of 40, four groups: control group (n=10), low intensity group (n=10), moderate intensity group (n=10), and high intensity group (n=10). The training was conducted for 8 weeks (60 minutes/5 days/weeks) at a speed of 9-26 m/min and a slope of 10°, which is low intensity (40%), moderate intensity (60%) and high intensity (80%) of rodent VO2max. Protein was extracted from Gastrocnemius, and insulin-related factors (GLUT4, PGC-1α) and autophagy-related factors (Beclin-1, ATG7) were analyzed using Western blotting. The results showed significant increases in both insulin and autophagy-related factors in the exercise population, with the highest expression in the medium-intensity exercise group. Therefore, these results are thought to have a positive effect associated with cellular homeostasis by increasing the expression of autophagy along with blood sugar improvement as an effect of exercise on T2DM aging rat.
황은아(Eun Ah Hwang),성정훈(Jung Hoon Sung),한승엽(Seung Yeup Han),박성배(Sung Bae Park),김현철(Hyun Chul Kim),김형태(Hyung Tae Kim),조원현(Won Hyun Cho) 대한내과학회 2002 대한내과학회지 Vol.63 No.3
목적 : 복막투석 환자에서 복막염은 복막투석의 실패와 사망에 가장 중요한 합병증의 하나이다. 저자들은 계명대학교 동산의료원에서 복막투석을 시행한 환자들을 대상으로 하여 복막염의 발생 및 역학에 대해 조사하였다. 방법 : 1996년 1월에서 2000년 12월 사이에 계명대학교 동산의료원에서 복막투석을 시행받은 환자들 중 추적기간이 2개월 이상인 238명을 대상으로 하여 후향적으로 조사하였다. 결과 : 5년간의 복막염의 발생율은 평균 0.94회/환자-년(12.8개월당 1회)이었고, 복막염 원인균의 빈도는 그람 양성균이 41.7%, 그람 음성균이 14.1%, 진균이 1% 순이었으며 배양 음성인 경우가 42.7%였다. 그람 양성균 중에는 Staphylococcus aureus가 47.5%로 가장 많았고, 그람 음성균에서는 Acinetobacter가 29.6%를 차지하였다. 균배양 양성율은 Bactec 혈액 배양 방식의 도입 이전 52.5%, 도입 후 72.2%로 균배양 양성율이 유의하게 향상되었다. 복막염은 항생제의 사용으로 치료된 예는 85.6%였고, 11.8%에서는 도관이 제거가 필요하였다. 도관을 제거하였던 경우 출구 감염이 도관을 제거하지 않 았던 군보다 유의하게 많았다(17.4% vs 4.7%). 전체 109명의 환자 중 60예에서 복막투석을 중단하였고, 그 중 28예가 혈액투석으로 전환하였으며 그 원인으로는 복막염이 82.1%로 가장 많았다. 도관 생존율은 복막염을 경험한 환자군에서는 1년, 3년, 5년 도관 생존율이 각각 87.0%, 35.1%, 11.9%였으며 복막염을 경험한 환자군에서는 1년, 3년, 5년 도관 생존율이 각각 81.7%, 58.1%, 54.0%였다. 관찰 기간 동안 6예가 사망하였으며 그 중 절반이 복막염에 의한 패혈증으로 사망하였다. 결론 : 앞으로 복막염의 발생을 감소시키기 위해서는 투석액 교환시 감염 및 도관 주위감염에 대한 적극적인 치료와 주기적인 환자 교육이 필요할 것으로 생각된다. Background : Peritonitis is one of the major complication leading to mortality and technique failure in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). We have examined the incidence and etiology of CAPD peritonitis at Keimyung University Dongsan medical center. Methods : Between January 1996 and December 2000, 238 new patients received peritoneal dialysis and were reviewed retrospectively. Results : In 238 patients, 109(45.8%) patients experienced peritonitis and a total of 192 episodes of peritonitis has occurred during study period. The overall incidence of peritonitis during CAPD averaged 0.94/patient-year and there was no essential change during the last five years. The most common causative organism was Gram positive organism (41.7%), followed by Gram negative organism (14.1%), and fungus (2%). In Gram positive organism, Staphylococcus aureus (47.5%) was the most common microorganism, followed by coagulase negative Staphylococcus (23.5%), Streptococci (7.5%), and Enterococci (5.5%). Gram negative organism were Acinetobactor (29.6%), Escherichia coli (18.5%), Klebsiella (18.5%) and Pseudomonas (7.4%) in decreasing order of frequency. With the use Bactec blood culture system for peritoneal fluid culture since April 2000, the culture yield has been improved significantly than before (52.5% vs 72.2%, p<0.05). Peritonitis was cured in 164 cases (85.6%) with the administration of antibiotics. However catheters had to be removed in 23 cases (11.8%). Exit-site infection was more frequent in catheter removal group than in catheter retaining group (17.4% vs 4.7%, p<0.05). The CAPD failure occured in 28 patients during study period, and peritonitis was the major reason for technique failure (82.1%). The catheter removal rate was significantly higher in the patients with peritonitis than those without peritonitis (55.0% vs 30.2%, p<0.05). There were six deaths during study period. Septicemia associated with peritonitis accounted for the half of the mortality. Conclusion : Better exit-site care and continuing patient education is needed the incidence of peritonitis and peritonitis related mortality in CAPD patient.(Korean J Med 63:314-321, 2002)
학교 건축물 내진보강 시공현장 관리를 위한 가이드라인 개발 및 적용에 관한 연구
황은아 ( Hwang Eun-a ),이병호 ( Lee Byoung-ho ),박구병 ( Park Ku-byoung ) 한국건축시공학회 2020 한국건축시공학회 학술발표대회 논문집 Vol.20 No.1
The government seismic retrofit project for educational facilities is progressing more actively due to the 2018 Pohang earthquake. It is most important that seismic retrofit constructions are conformed to seismic design to achieve the desired purpose of the project as reduce direct damage caused by earthquake. However, the construction supervision system is not mandatory for the retrofit construction site of small buildings including school buildings according to applicable laws and regulations. The purpose of this study was to develop a guide for constructions management of school building seismic retrofit. In order to achieve this goal, the survey on the construction site was conducted and various problems related to the construction site of school building seismic retrofit was derived Additionally, the systematic checklist was presented according to the user and seismic reinforcement method.
중환자실에 입원한 급성 신부전 환자에서 지속적 신대체요법
황은아 ( Eun Ah Hwang ),윤정수 ( Jeong Soo Yoon ),장미현 ( Mi Hyun Jang ),김정은 ( Jung Eun Kim ),강성식 ( Seong Sik Kang ),최고 ( Go Choi ),한승엽 ( Seung Yeup Han ),박성배 ( Sung Bae Park ),김현철 ( Hyun Chul Kim ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Purpose: The mortality rate in critically ill patients with acute renal failure (ARF) remains unacceptably high, despite numerous advances in dialysis techniques and intensive care medicine. We evaluated clinical characteristics and prognostic factors in ICU patients with ARF requiring continuous renal replacement therapy (CRRT). Methods: We retrospectively reviewed the medical records of all ICU patients who received CRRT at the Keimyung University Dongsan Hospital from September 2002 to October 2007. Results: Total number of patients who required CRRT in ICU was 58. The mean age was 58.3±14.8 years. The treatment duration of CRRT was 63.5±40.7 hours. The mechanical ventilation rate was 82.8%, vasoactive drug 79.3%, sepsis 39.7%. APACHE II score was 25.2±7.9, SAPS II score 48.1±15.1, CCF score 9.3±3.6, the number of organ dysfunction 2.1±1.3. Overall mortality rate was 48%. When we compared sepsis group with non-sepsis group, the number of organ dysfunction and severity of illness were significantly higher in sepsis group than that of non-sepsis group. A mortality rate of sepsis group was significantly higher than non-sepsis group (82.6% vs 31.3%, p<0.001). In univariate analysis, significant risk factors for mortality were the number of organ dysfunction, severity of illness, MAP, platelet count, serum albumin level, and a type of hemofilter. Significances of all these factors were lost in multiple linear regression analysis. Conclusion: A large scaled, prospective randomized multi-center trials are needed to confirm the beneficial effect of CRRT in patient with ARF in ICU.