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항암제 병용요법이 가토 혈액상에 미치는 영향에 관한 실험적 연구
김학원(Hak Won Kim),황경곤(Kyung Kon Hwang) 대한악안면성형재건외과학회 1986 Maxillofacial Plastic Reconstructive Surgery Vol.8 No.1
N/A The purpose of this study was to observe the clinical appearances and the hematologic alterations in rabbits when the anticancer drugs: Bleomycin, Cyc1ophosphamide, Methotrexate and 5-Fluorouracil (B-CMF) of the clinical and experimental doses are administered to the rabbits. For this study, the 20 rabbits, weighing about 2kg, were used and divided into the clinical and experimental dosage groups. In the clinical dosage group, B-CMF regimen was initiated with bleomycin 0.05 mg/kg per day for four days. 24 hours rest period followed the bleomycin, and then, a combination of cyclophosphamide 20 mg/kg, 5-fluorouracil 40 mg/kg per day for five days, and methortrexate 2 mg/kg on days one and five was given. All of these agents were given intramuscularly. The experimental dose was 1/8 of the clinical dose and it was the same schedule of administration as the clinical dosage group. The clinical study was to observe alopecia, mucositis and miscellaneous clinical changes everyday. The laboratory study was to observe hematologic changes on the 1st, 5th, 11th, 14th, 17th, 20th, 25th and 28th day from the 1st day of experiments. The rabbits were anesthetized by injecting the Ketamine Hcl of 7 mg/100grn of body weight intramuscularly. When the rabbits were anesthetized, 1ml blood was collected from the femoral and jugular veins. The blood samples were immediately used for the counts of the r blood cell, white blood cell, hematocrit, hemoglobin and platelet, and was made smear for the differential counts of white blood cell. The counts of the red blood cell, white blood cell and platelet were made by standard method and the counts of differential leukocyte were conducted through the examination of blood films with Wrights stain, The hemoglobin concentration was determined with Hemophotometer (Fisher Co.) and the hematocrit value was determined by the capillary hematocrit method. The mean corpuscular volume (M.C,V), mean corpuscular hemoglobin (M.C.H.), and mean Corpuscular hemoglobin concentration (M.C.H.C.) were calculated by the Wintrobe method. The following results were obtained: 1. Mucositis of degree 1 (oral redness) was observed on the 14th and 1.7th day, and was re- covered on the 25th day, 2. Alopecia was partially observed from the 5th day and was moderately severe from the 8th day. 3. All of the clinical dosage groups were died on the 7th and 8th day. Three of the experimental dosage groups were died w the 9th and 10th day, and their mortality rate were 30%. 4. In the experimental dosage group, the counts of the white blood cell and platelet were significantly reduced on the 14th and 17th day. 5. Neutrophil was slightly reduced on the 14th, 17th and 20th day, but others were within normal range. 6. Each blood count returned to the pre-experimental state n the 25th and 28th day.
증예보고 : 하악골에 발생한 해면동상 골혈관종의 치험예
김학원(Hak Won Kim),구자용(Ja Ryoung Koo),황경곤(Kyung Kon Hwang) 대한악안면성형재건외과학회 1985 Maxillofacial Plastic Reconstructive Surgery Vol.7 No.1
This is a case report of cavernous central hemangioma of the mandible by hemimandiblectomy and bone graft for reconstruction of the mandible. Before the operation, we performed the external carotid angiography. It was proper evaluation of vascular supply in preoperation. And then, we performed the hemimandiblectomy under external carotid artery ligation and hypotensive anesthesia. Also, bane graft performed for construction of the mandible after 6 months. Post-operative results are good and no recurrence occurred.
파골세포분화유도 수용기인 RANK의 신호전달물질에 관한 연구
황경곤,허남기,이장희 朝鮮大學校 口腔生物學硏究所 2000 口腔生物學硏究 Vol.24 No.1
Receptor activator of NF-κB (RANK) is a recently cloned member of the tumor necrosis factor receptor (TNFR) superfamily, and its function has been implicated in the differentiation, survival of osteoclasts and dendritic cells. Many of the TNFR family receptors recruit warious members of the TNF receptor-associated factor (TRAF) family for transduction of their signals to NF-κB. In this study, the involvement of IKK molecules in NF-κB pathway and the activation of the ERK and p38 pathway in signal transduction by RANK were investigated. Expression of RANK in cultured cells induced the activation of IKK. and slightly induces the activation of p38, however, did not induce the activation of ERK. These results suggest that IKK and p38 might involve in RANK signaling pathway.
지재휴,이병준,김영균,김수관,황경곤,여환호,박인순 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3
Deep burns of the face & lips often lead to scarring and contraction of the circum-oral tissues with a marked reduction in the size of the oral aperture. Such burns most commonly caused by electrical contact, for example, children sucking electric plugs, or as a result of chemical burns and the exposture to flame. Once having burns, burned tissue may contract and reduce considerably the size and mobility of the mouth ; therefore bring up the resultant functional disturbance, verbal difficulty, even disgestive difficulty, and poor appearance, which fall into difficulty in social acceptability, caused by burns. In our department, 2 patients who were complain of functional limitations and esthetic problem owing to scar contracture, were visited, and we treated this microstomia with scar excision, graft and flap technique, and postoperative intensive physical therapy. We obtained relatively favorable results, thus report this cases with literature review.