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파골세포분화유도 수용기인 RANK의 신호전달물질에 관한 연구
황경곤,허남기,이장희 朝鮮大學校 口腔生物學硏究所 2000 口腔生物學硏究 Vol.24 No.1
Receptor activator of NF-κB (RANK) is a recently cloned member of the tumor necrosis factor receptor (TNFR) superfamily, and its function has been implicated in the differentiation, survival of osteoclasts and dendritic cells. Many of the TNFR family receptors recruit warious members of the TNF receptor-associated factor (TRAF) family for transduction of their signals to NF-κB. In this study, the involvement of IKK molecules in NF-κB pathway and the activation of the ERK and p38 pathway in signal transduction by RANK were investigated. Expression of RANK in cultured cells induced the activation of IKK. and slightly induces the activation of p38, however, did not induce the activation of ERK. These results suggest that IKK and p38 might involve in RANK signaling pathway.
NF-kB Family Transcription Factors
Chung, Pa Jin,Hwang, Kyung Kon,Kim, Hong Hee 朝鮮大學校 口腔生物學硏究所 1999 Oral Biology Research (Oral Biol Res) Vol.23 No.1
NF-κB is a eucaryotic transcription factor that exists in virtually all cell types. More than a decade after its discovery, remains an exciting and active area of study. A primary level of control for NF-κB is through interactions with an inhibitor protein called IκB. recent evidence confirms the existence of multiple forms of IκB that appear to regulate NF-κB by distinct mechanisms. NF-κB can be activated by exposure of cells to LPS or inflammatory cytokines such as TNF or IL-1, viral infection or expression of certain viral gene products, UV irradiation, B or T cell activation, and by other physiological and nonphysiological stimuli. Activation of NF-κB to move into the nucleus is controlled by the targeted phosphorylation and subsequent degradation of IκB. Exciting new research has elaborated several important and unexpected findings that explain mechanisms involved in the activation of NF-κB. In the nucleus, NF-κB dimers bind to target DNA elements and activate transcription of genes encoding proteins involved with immune or inflammation responses and with cell growth control.
구강 악안면 연조직 결손 재건을 위한 진피 지방 이식의 이용 : 증례보고
김수관,박노승,이병준,황경곤,여환호,김영균 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3
Soft tissue defects in oral & maxillofacial region caused by tumor resection, trauma, congenital deformities have been treated in autogenous soft tissue flap, allogenic material, free dermal graft, fascia graft. Of these methods, autogenous dermis graft had initially been applied in hernia treatment at the beginning of nineteenth century and have been applied in soft tissue augmentation coverage of vital structure, dead space removal and reconstruction of fascia. A fat graft is used in reconstruction of orbit at the enucleation, restoration of facial contours, etc. In this case, patient with chin soft tissue defect in traffic accident was treated in autogenous dermis-fat graft from patient's abdominal and gluteal region. Chin defect was recons ructed favorably. There was no severe atrophy of grafted area 12 months postoperatively. We will report the result that is favorable esthetically with literature review.