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구면기준 Shack-Hartmann Test 장치를 이용한 대형 반사경 정밀 가공 연구
홍정희(Jong Hui Hong),오창진(Chang Jin Oh),이응석(Eung Suk Lee),김옥현(Ock Hyn Kim) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.11
Spherical surface refereneced Shack-Hartmann Test aparatus is based on Shack-Hartmann test has been developed which is known to have good robustness compared with the interferometry. This is capable of provideing the accuracy of p-v 82㎚. Measurement data converted into Dwell time is used for polishing procsess. Finally, the large mirror has residual figure error about p-v 472㎚.
키랄 HPLC를 이용한 원료 및 제제로부터 클로르페니라민 광학이성질체의 분석
조종운,김경태,이은주,홍정희,채규한,이은실,강종성 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Chlorpheniramine(CPM) is an antiallergic drug with H1 antihistamine properties. The molecule has an asymmetric carbon, hence, two stereoisomers, d- and l-CPM, are available. It was reported that d-CPM showed higher antihistaminic effect than l-CPM, which was eliminated slower than d-CPM in CYP2D6 metabolism. The method of chiral separation for CPM enantimers was developed and the validated method was then applied to the quality control of raw materials and pharmaceutical formulations of CPM. The chiral analysis was carried out on a chiral stationary phase, Chiralcel OJ-H (0.46 × 15 cm, 5 μm), with the mobile phase of hexane : ethanol : diethylamine (98 : 2 : 0.1, v/v/v) in 0.3 ml/min. The eluent was monitored at UV 262 nm. The validation studies were carried out according to ICH requirements. The mean concentration of l-CPM in racemic raw materials and formulations were 42.8~53.5%, while those of d-CPM were 44.2~56.0%, and total mean concentration of dl-CPM was 91.4~108.5%. All commercially available samples showed good results within KP range, except some pharmaceutical formulations containing dextromethorphan due to the incomplete separation of d-CPM, dextromethorphan and l-CPM.