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홍용기(Yong-Ki Hong),조연옥(Yeon-Ok Cho),정상기(Sang-gi Jung),채남희(Name-Hee Che),안우희(Woo-Hee Ahn) 한국철도학회 2015 한국철도학회 학술발표대회논문집 Vol.2015 No.10
철도기술 환경변화에 대응한 철도기술개발과 240 조원 이상의 철도시장 해외진출 경쟁력 확보를 위해 세계 각국의 철도연구기관 및 운영기관 등에서 수행하였거나 계획하고 있는 기술개발 현황과 미래기술 등의 연구 아이템을 조사/분석하였다. 해외 철도기술분석대상은 37 개기관으로 해외철도기관의 발전계획, 연차보고서, 연구보고서 등의 기술자료를 통해서 연구개발 테마와 트렌드를 조사 분석한 것이다. I have searched and analyzed of development of railway technology which is corresponding to environmental change of railway technology, and also have searched and analyzed of development status and future technology research items which is already carried out or planning technical developments for setting aside competitiveness of more than 240 trillion won’s overseas railway market. I have investigated and analyzed that research and development themes and trends according to 37 overseas railway organizations’ technical articles such as development plans, annual reports, research reports, etc.
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규칙적인 유산소운동에 따른 혈중지질 및 HPA axis 호르몬의 변화
홍성찬 ( Hong Seong Chan ),함용기 ( Ham Yong Gi ),이정윤 ( Lee Jeong Yun ),박병근 ( Park Byeong Geun ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.1
The purpose of this study was to evaluate the effect of regular aerobic exercise on blood lipid and HPA axis hormone in middle-aged women. The subject for this study were 14 healthy women who were 35-45years. They didn`t have any history cardiovascular disease. The subject were divided into two group: swimming (experimental) group (n=7) and control group (n=7). The swimming exercise protocol for experimental group consisted of a 10-minute warm-up, 40-minute main exercise, and 10-minute cool down. Exercise intensity was range from 55% to 80%HRmax. Exercise was performed 5-6 days/a week during 16 weeks. The result of this study as follows. 1. The change of blood lipid variable. 1) The TC of an experimental group was decreased significantly, whereas that of a control group was no significant different after exercise. 2) The TG of an experimental group was decreased significantly, whereas that of a control group was no significant different after exercise. 3) The HDL-C of an experimental group were increased significantly whereas that of a control group was no significant different after exercise. 4) The ACTH of an experimental group were increased significantly, whereas that of a control group was no significant different after exercise. 5) The cortisol of an experimental group were increased significantly, whereas that of a control group was no significant different after exercise. In conclusion, swimming exercise performed during 16 weeks in this study was affected positive change in blood lipid and HPA axis hormone. Therefore we think the swimming exercise seems to be a available method for improving cardiovascular disease and lipid utilization.
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35종 해조류 추출물의 in-vitro 항혈전 활성 평가
Seon-Mi Ahn(안선미),Yong-Ki Hong(홍용기),Gi-Seok Kwon(권기석),Ho-Yong Sohn(손호용) 한국생명과학회 2010 생명과학회지 Vol.20 No.11
혈전성 질환을 예방, 개선할 수 있는 안전한 항혈전제를 개발하기 위해, 일반적으로 항혈전 효과가 있다고 알려진 식용 해조류 35종(갈조류 17종, 홍조류 11종 및 녹조류 7종)을 대상으로 메탄올 추출물을 조제하고, 이들의 thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (aPTT)을 평가하였다. 트롬빈 저해(TT)의 경우 35종 중에서 감태, 곰피, 대황, 넓패, 패, 알송이모자반 및 야마다모자반에서 강력한 활성을, 프로 트롬빈 저해(PT)의 경우 트롬빈 저해활성이 나타난 7종 중 야마다모자반을 제외한 6종에서 강력한 활성을 확인하였으며, 혈액응고인자 저해(aPTT)에서는 감태, 곰피, 대황, 넓패, 패, 알송이모자반 및 톳에서 강력한 활성이 나타났다. 선별된 8종의 시료를 대상으로 다양한 농도에서 항혈전 활성을 평가한 결과 알송이모자반에서 가장 강력한 활성을 확인하였으며, 곰피, 대황 및 넓패가 효과적이었다. 항혈전 활성과 해조류 추출물의 총 flavonoid, 총 polyphenol, 총당 및 환원당 함량과의 상관 관계를 검토한 결과, 활성물질은 flavonoid성 물질로 추측되었으며, 선별된 8종은 총 flavonoid 함량 및 총 polyphenol 함량이 매우 높은 특징을 나타내었다. 본 연구 결과는 경제적이면서 대량공급이 가능한 식용 해조류로부터 신규의 안전한 항혈전제 개발이 가능함을 제시하며, 야마다모자반과톳은 트롬빈 또는 혈장내 응고 인자에 대한 특이 저해제로 개발 가능함을 제시하고 있다. Seaweeds have been recognized as a health food, having anti-obesity, anti-constipation and anticoagulation activities, and the use of seaweeds in the food, medicine, and cosmetic industries have recently significantly increased. In this study, methanol extracts were prepared from 35 different seaweeds (17 phaeophyta, 11 rhodophyta and 7 chlorophyta), and thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (aPTT) were determined in order to develop safe and novel anticoagulation agents from natural products. In TT experiments, Ecklonia cava, Ecklonia stolonifera, Eisenia bicyclis (Kjellman) Setchell, Ishige foliacea, I. okamurai, Sargassum confusum and S. yamade showed strong thrombin inhibition activity among the 35 different seaweeds. In PT experiments, the inhibitions of prothrombin were identified in the selected seaweeds from TT experiment, with the exception of S. yamade. In aPTT experiments, the seaweeds with blood coagulation inhibition factors were E. cava, E. stolonifera, E. bicyclis (Kjellman) Setchell, I. foliacea, I. okamurai, S. confusum and Hixikia fusiforme Okamura. Further anticoagulation assay with the selected 8 seaweeds suggested that S. confusum is most effective in antithrombosis, and E. stolonifera, E. bicyclis (Kjellman) Setchell, and I. foliacea have high potential as antithrombosis agents. Based on components-activity correlation analysis, flavonoids are considered as active anticoagulation components of seaweeds These results suggest that edible seaweeds, especially S. confusum, have potential as safe and novel anticoagulants, and S. yamade and H. fusiforme Okamura could be used as a thrombin-specific and coagulation factor-specific inhibitors.
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해조류 추출물의 항산화 및 nitrite 소거활성 평가
Seon-Mi Ahn(안선미),Yong-Ki Hong(홍용기),Gi-Seok Kwon(권기석),Ho-Yong Sohn(손호용) 한국생명과학회 2011 생명과학회지 Vol.21 No.4
유용생리활성의 해조류를 이용한 식품소재 개발 연구의 일환으로, 35종 해조류(갈조류 17종, 홍조류 11종 및 녹조류 7종)의 메탄올 추출물을 대상으로 in-vitro항산화 및 nitrite 소거활성을 평가하였다. 해조류 추출물(500 ㎍/㎖) 중 감태, 곰피, 대황, 넓패, 패, 모자반, 알송이모자반, 야마자모자반 및 잘피의 9종에서 60% 이상의 DSA활성을 나타내었으며, ASA활성은 DSA활성과 높은 상관관계를 나타내었다(상관계수 0.855). 환원력 평가 결과에서는 감태, 곰피 및 대황의 3종만이 0.88 (Abs???) 이상의 강력한 활성을 나타내었다. 한편 식품에서의 발암인자인 nitrosoamine생성억제와 관련된 NSA평가의 경우, 전체 35종의 해조류 중 19종에서 60% 이상의 NSA를 나타내었으며, 특히 기존에 알려지지 않은 모자반, 야마다모자반, 알송이모자반, 패, 넓패에서 우수한 활성을 확인하였다. 1차 선별된 9종 해조류의 DSA, ASA, NSA의 IC??를 조사한 결과, 기존의 항산화능이 알려진 곰피, 대황, 감태 이외에도 야마다모자반 및 넓패에서 강력한 항산화 활성과 nitrite 소거활성을 확인하였다. 본 연구결과는 야마다모자반 및 넓패를 이용하여 항혈전, 항산화, NSA 활성을 동시에 나타내는 기능성 식품소재로의 개발이 가능함을 제시하고 있다. In the course of study for the development of functional food ingredients from seaweeds having useful biological activities, the in-vitro antioxidant and nitrite scavenging activities of the methanol extracts prepared from 35 different seaweeds (17 phaeophyta, 11 rhodophyta and 7 chlorophyta) were determined. At 500 ㎍/㎖ concentration of the methanol extracts, Ecklonia cava, Ecklonia stolonifera, Eisenia bicyclis(Kjellman) Setchell, Ishige foliacea, I. okamurai, Sargassum confusum, S. fulvellum, S. yamade and Zostera marina showed 60% more DPPH and ABTS scavenging activity. The exceptions were found in I. okamurai and Z. marina, which showed 45% and 53% ABTS scavenging activity, respectively. The correlation coefficient between DPPH and ABTS scavenging activities was 0.855, suggesting that the 9 different seaweeds extracts could scavenge anion and cation radicals concurrently. In reducing power, only E.cava, E.stolonifera and E.bicyclis showed above 0.88 (Abs???). In a while, in nitrite scavenging activity at 100 ㎍/㎖ concentration of the methanol extracts, 19 different seaweeds extracts including I. foliacea, I. okamurai, S. confusum, S. fulvellum, and S. yamade showed 60% more activity. Calculation of IC??s of DPPH, ABTS and nitrite scavenging activities of 9 different seaweeds extracts further showed that I. foliaceaand S. yamade, besides E.cava, E.stolonifera and E.bicyclis, have strong antioxidant and nitrite scavenging activity. These results suggest that the selected 9 different seaweeds could be developed as functional food ingredients and I. foliacea and S. yamade have potential as novel natural sources of antioxidant and nitrite scavenger.
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