연구단보 : 건조 및 저장조건에 따른 쌀 저장단백질의 변화양상

신평균 ( Pyung Gyun Shin ),장안철 ( An Cheol Chang ),홍성창 ( Seong Chang Hong ),이기상 ( Ki Sang Lee ),이금희 ( Keum Hee Lee ),이용복 ( Yong Bok Lee ) 한국환경농학회 2008 한국환경농학회지 Vol.27 No.4

Quality of rice grain changes during dry storage with internal physiological changes and external injury by organism. Storage rice changes by condition with respiration via variable temperature, hydrolysis enzyme reaction, lipid peroxidation occurs with change of palatability. During dry storage, physiological change with protein variation pattern was examined by image analysis on proteomic technology. Analysis revealed that protein activity had no change store at room temperature and store at 40℃, but decreased store at 60℃. Analysis of variable hydrophobic protein pattern revealed that protein activity of beta-tubulin, protein disulfide isomerase, vacuolar ATPase b subunit, globulin was not significantly decreased all dry and store condition. However, heat shock protein 70, and glutathione transferase was significantly decreased when rice dried at 60℃ compared with room temperature and 40℃ dry condition.

05 포스터 발표 : PN-08 ; 광 파장과 품종별 상추 발아의 광가역성

홍성창 ( Seong Chang Hong ),김민경 ( Min Kyung Kim ),김명현 ( Myoung Hyun Kim ),최순군 ( Soon Kun Choi ),어진우 ( Jin Woo Eo ),정구복 ( Goo Bok Jung ),소규호 ( Kyu Ho So ) 한국환경농학회 2014 한국환경농학회 학술대회집 Vol.2014 No.-

적색광에 의해 유도된 반응이 초적색광에 의해 무효화 되는 작용인 광가역성(photoreversibility)은 식물의 광생리에서 중요한 반응이다. 식물의 광가역성 반응은 광수용단백질인 파이토크롬이 매개하는 작용으로 잘 알려져 있다. 따라서 파이토크롬 작용을 유도하는 적색광과 초적색광은 식물의 광반응을 유도하는 주요한 광파장이다. 본 연구는 상추의 발아에 대한 적색광과 초적색광의 작용을 재확인하면서 백색광의 광가역성반응 가능성을 평가하고, 국내에서 재배되는 10개 상추품종의 발아의 광가역성을 검증하기 위하여 수행하였다. 본 연구는 LED 광원을 이용하여 적색광(660nm), 청색광(470nm) 초적색광(730nm), 백색광(300∼1100nm)이 설치되어 광원별 처리시간을 조절할 수 있는 자체 제작한 광가역성 처리장치를 이용하였다. 상추는 청상추 품종인 그랜드래피드를 이용하였다. 광 파장별 처리시간은 암흑 상태에서 5분간 처리하였다. 적색광 처리구(R)는 적색광 5분, 적색광+초적색광 처리구는(R+FR) 적색광 5분+초적색광 5분간 처리하였고, 적색광+초적색광+적색광(R+FR+R) 처리구는 적색광 5분+초적색광 5분+적색광 5분을 하루에 3회 처리하였다. 청색광 처리구는 청색광, 청색광+초적색광, 청색광+초적색광+청색광을 순차적으로 처리하였고 백색광 처리구는 백색광, 백색광+초적색광, 백색광+초적색광+백색광을 순차적으로 처리하였다. 상추의 발아율은 적색광 처리에서 초적색광에 의해 감소되고 연이은 적색광에 의해 증가하여 광가역성을 나타냈다. 청색광 처리구에서는 청색광에 의한 발아율이 초적색광에 의해 감소되지 않아 광가역성을 나타내지 않았다. 또한 백색광 처리에서 상추의 발아율은 초적색광에 의해 감소하고 연이은 백색광 처리에 의해 증가하여 광가역성을 나타내는 경향이었다. 이러한 결과는 백색광(300∼1000nm)이 적색광을 일정 비율 포함하고 있어 파이토크롬의 작용을 일부 유도하였기 때문으로 판단된다. 앞으로 백색광과 연관된 식물의 광가역성반응이 심도있게 확인된다면 농작물의 생육, 개화를 조절하는 기술로 응용될 수 있을 것으로 예상된다. 상추 품종별 발아의 광가역성반응은 청상추품종들에서 강하게 나타나는 경향이었다.

항암치료 환자의 B형 및 C형 간염바이러스 감염과 간기능 이상

권창일 ( Chang Il Kwon ),이지현 ( Ji Hyun Lee ),최기현 ( Ki Hyun Choi ),고광현 ( Kwang Hyun Ko ),홍성표 ( Sung Pyo Hong ),황성규 ( Seong Gyu Hwang ),박필원 ( Pil Won Park ),오도연 ( Do Yeun Oh ),임규성 ( Kyu Sung Rim ),김세현 ( Se 대한소화기학회 2006 대한소화기학회지 Vol.48 No.6

Background/Aims: Liver dysfunction and reactivation of hepatitis virus are well-described complications in cancer patients who receive cytotoxic chemotherapy and may result in varying degrees of liver damage. However, there has been just few reports on such complications and on the preemptive use of lamivudine in Korea. The aims of this study were to determine the prevalence of hepatitis B and C virus infection and the incidence of liver dysfunction in patients with malignancies who receive chemotherapy, to determine the reactivation rate of hepatitis B virus (HBV) in those patients, to evaluate the effect of preemptive use of lamivudine in patients with HBV infection. Methods: Among 1,477 patients who received chemotherapy due to various malignancies from January 2000 to June 2005, 668 patients with incomplete viral studies or hepatitis related malignancy were excluded. A retrospective study was conducted by reviewing the medical records of remaining 809 patients. Results: The overall prevalence rate of hepatitis B or C virus in patients receiving chemotherapy was 6.55% (53/809). The incidences of liver dysfunction was not significantly different between hepatitis virus positive group and negative group. Reactivation rate of hepatiris B or C virus after chemotherapy was 15% (6/40). In all patients who received lamivudine therapy, aspartate aminotransferase and alanine aminotransferase level were normalized and HBV DNA negativity achieved. Conclusions: The existence of hepatitis virus in patients receiving chemotherapy did not significantly influence the development of severe liver dysfunction, owing probably to the lamivudine therapy. Further prospective studies are required to ascertain the reactivation of hepatitis virus in patients receiving chemotherapy and the need for prophylactic lamivudine therapy in HBV positive patients. (Korean J Gas­troenterol 2006:48:408-414)

크론병 환자에서 Coxsackie Virus B 감염에 의한 급성 확장성 심근병증 1예

권창일(Chang IL Kwon),홍성표(Sung Pyo Hong),최유정(Yu Jeogn Choi),황경화(Kyung Hwa Hwang),오재인(Jane Oh),김경철(Kyung Chul Kim),황성규(Seong Gyu Hwang),박필원(Pil Won Park),임규성(Kyu Sung Rim) 대한소화기학회 1999 대한소화기학회지 Vol.34 No.1

A 23-year-old man was admitted for watery diarrhea, abdominal pain and fever. He had received an operation for an anal fistula at a private clinic about 3 years ago. Recently, he was treated under the diagnosis of tuberculosis colitis for about 15 months at another hospital, but showed no improvement. He lost 30 kg of weight for last 18 months. On admission, he was 178 cm high and weighed 50 kg. He had a pararectal abscess and a fistula between terminal ileum and sigmoid colon. He was diagnosed as Crohn's disease. After taking 2 weeks of medications composed with sulfasalazine, corticosteroid, 6-mercaptopurine and antibiotics, his condition improved rapidly and gained 5 kg of weight. On the 6th hospital week, he complained of dyspnea on exertion and orthopnea. His chest X-ray revealed a marked cardiomegaly, while his heart was normal in size and shape. He was diagnosed as dilated cardiomyopathy caused by coxsackie virus B, which was confirmed by serologic test. He died at the 46th hospital day. We report this case with a review of literature. (Kor J Gastroenterol 1999;34:125 - 130)

수치사진 측량을 이용한 DTM 추출 및 정확도 분석

박진성(Park, Jin Seong),홍성창(Hong, Sung Chang),성재열(Sung, Jae Ryeol),이병환(Lee, Byung Hwan) 한국측량학회 2010 한국측량학회 학술대회자료집 Vol.2010 No.4

최근 GIS는 2차원 공간상에서 정보를 표현하고 서비스하는 형태에서 벗어나 3차원 공간상에서 정보를 표현하고 서비스를 제공하는 형태로 급속도로 변화하고 있으며, 기술 개발 또한 활발하게 진행되고 있다. 3차원의 정보를 표현하기 위해서 기반이 되는 것은 지형의 표고정보(DTM)이다. 일반적으로 DTM을 얻기 위하여 LIDAR 데이터나 수치지도의 등고선 자료를 사용하고 있지만 이러한 데이터를 사용하여 DTM을 제작할 경우 추가적인 비용과 데이터 처리 시간이 발생할 뿐만 아니라 신속한 지형의 갱신이 어려운 문제점이 있다. 본 논문에서는 디지털 항공사진을 이용하여 문제 해결의 가능성을 판단하기 위해 항공사진 모델의 자동 매칭 방법을 사용하여 DTM을 추출하였으며, 수치사진측량으로 부터 추출된 DTM과 GPS 측량에 의한 정표고 성과 데이터와 정확도 분석을 실시하였다. 그 결과 RMSE는 0.215m로 비교적 높은 정확도를 얻을 수 있었다. Recently GIS is not only displaying and servicing data on the 2D, but also is changing rapidly to display and service 3D data. Also 3D related technology is developing actively. For display of 3D data, terrain DTM has become a basis. Generally, to acquire DTM, users are using LIDAR data or digital map"s contour line. However, if using these data for producing DTM, users need to additional cost and data lead time. And hard to update terrain data. For possibility of solving these problem, this study did DTM extraction with automatic matching for aerial photograph, and analysed the result with measurement of Orthometric height and excuted accuracy through DTM(which extracted from digital photogrammetric technique). As a result, we can get a high accuracy of RMSE (0.215m).

Helicobacter pylori 제균치료에서 Levofloxacin 병합요법의 효과

이지현 ( Ji Hyun Lee ),홍성표 ( Sung Pyo Hong ),권창일 ( Chang Il Kwon ),편래현 ( Lea Hyun Phyun ),이병석 ( Byoung Sok Lee ),송한얼 ( Han Ul Song ),고광현 ( Kwang Hyun Ko ),황성규 ( Seong Gyu Hwang ),박필원 ( Pil Won Park ),임규성 대한소화기학회 2006 대한소화기학회지 Vol.48 No.1

Background/Aims: The failure rates of first and second line therapies of Helicobacter pylori (H. pylori) eradication range from 15 to 20%. This study was aimed to evaluate the efficacy and safety of levofloxacin based triple therapy compared with standard triple or quadruple therapy for H. pylori eradication in Korea. Methods: We enrolled two hundred and sixty seven patients with presence of H. pylori infection. One hundred and forty-one patients were treated with levofloxacin based triple therapy (LAP; levofloxacin, amoxicillin, proton pump inhibitor; PPI), and 126 patients were treated with standard triple therapy (CAP; clarithromycin, amoxicillin, PPI). We retreated the patients who had failed in H. pylori eradication with standard quadruple second-line therapy (MTPB; metronidazole, tetracycline, PPI, bismuth subcitrate) or levofloxacin based therapy (LAP or LCP; levofloxacin, clarithromycin, PPI). Results: In first line therapy of H. pylori eradication, the eradication rates of levofloxacin based triple therapy and standard triple therapy were 69.8% and 74.0% respectively (p=0.52). In second-line therapy, the eradication rate of levofloxacin based triple therapy and standard quadruple therapy were 62.5% and 40.0% respectively (p=0.34). Conclusions: Levofloxacin based triple therapy is effective as standard regimen to eradicate H. pylori infection and is useful for an alternative rescue therapy as well. (Korean J Gastroenterol 2006;48:19-24)

증기용 밸브 성능검증 시험설비 및 인증체계 구축 현황

이상혁(Sang Hyuk Lee),홍성창(Seong-Chang Hong),고진욱(Jin Wook Ko),류경하(Kyungha Ryu),김병덕(Byungduck Kim),김재형(Jaehyung Kim) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12

수원과 여주지역의 강우 화학적 특성 및 부하량 평가

김민경(Min-Kyeong Kim),홍성창(Seong-Chang Hong),채미진(Mi-Jin Chae),권순익(Soon-Ik Kwon),정구복(Goo-Bok Jung),이종식(Jong-Sik Lee),윤순강(Sun-Gang Yun),소규호(Kyu-Ho So) 한국토양비료학회 2013 한국토양비료학회 학술발표회 초록집 Vol.2013 No.10

폐금속광산 하류 수계의 수질 변화와 오염도 평가

정구복(Goo-Bok Jung),홍성창(Seong-Chang Hong),김민경(Min-Kyeong Kim),김명현(Myung-Hyun Kim),최순군(Soon-Kun Choi),어진우(Jin-U Eo),조광진(Kwang-Jin Cho),소규호(Kyu-Ho So) 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.10

허혈성 심장 환자에서 프로톤펌프억제제와 Clopidogrel 병용투여 효과

김원희 ( Won Hee Kim ),홍성표 ( Sung Pyo Hong ),김용훈 ( Yong Hun Kim ),김도형 ( Do Hyung Kim ),정준구 ( Jun Gu Chung ),박일 ( Il Park ),이중민 ( Jung Min Lee ),권창일 ( Chang Il Kwon ),고광현 ( Kwang Hyun Ko ),황성규 ( Seong Gyu 대한내과학회 2011 대한내과학회지 Vol.80 No.4

Background/Aims: It has recently been suggested that proton pump inhibitors (PPIs) might reduce the inhibitory effect of clopidogrel on platelet aggregation. Co-administration of a PPI and clopidogrel in patients with ischemic heart disease may thus alter clinical outcome. We investigated the effect of concomitant use of a PPI with clopidogrel in Korean patients with ischemic heart disease. Methods: This is a retrospective cohort study of 99 patients with acute coronary syndrome taking clopidogrel and PPIs after discharge from CHA Bundang Medical Center between January 1, 2003, and December 31, 2007. The control group consisted of 99 patients who were matched for age and sex but were not taking PPIs. Results: Patients who received clopidogrel plus PPI had a greater than two times higher risk of re-admission or death (adjusted hazard ratio 2.51; 95% confidence interval [CI] 1.43~4.40; p = 0.001) than those who received clopidogrel alone. Lansoprazole use was associated with an increased risk of re-admission or death (adjusted hazard ratio 2.66; 95% CI 1.45~4.89; p = 0.002). Combined period of administration or Helicobacter pylori infection did not affect the risk of re-admission or death. Conclusions: Particular attention should be paid when patients with ischemic heart disease are prescribed a combination of clopidogrel and a PPI, since this combination was associated with an elevated risk of re-admission or death. (Korean J Med 2011;80:434-442)