http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 허승식(Sung Sik Hur) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
B 형 만성활동성간염 환자에서 Prednisolone 단기 이탈 및 Alpha Interferon 병합요법의 효과
이종선(Chong Sun Lee),김병호(Byung Ho Kim),성자원(Ja Won Sung),허승식(Sung Sik Hur),이기천(Ki Cheon Lee),정현용(Hyun Yong Jeong),이헌영(Heon Young Lee),김영건(Young Kun Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.5
Background: There is no satisfactory method of treatment for chronic active hepatitis caused by hepati- tis B virus(CAH-B). Randomized controlled studies on a limited number of patients with CAH-B using alpha interferon or combination with corticosteroid showed some promise in reducing or eliminating viral replication. We evaluated thc safety and efficacy of prednisolone withdrawal followed by recombinant alphaInterferon 2b therapy. Methods: Sixteen patients (treatment group) with CAH-R were injected alpha-Interferon for 16 weeks after prednisolone tapered for 6 weeks, and compared to 12 controlled patients (control group). We measured serum aminotransferase activities, HBsAg, Anti-HBs, HBeAg, Anti-HBe and HBV-DNA before and after therapy. Results: I) Serum levels of AST and ALT were decreased significantly in treatment group (AST: 36±17, ALT: 38±14 IU/L) compared to control group (AST: 188±152, ALT: 272±155 IU/L). The responses were maintained for 1 year after therpy. 2) The negative conversion rates of HBeAg and HBV-DNA were significantely higher in treatment group (HBsAg: 50%, HBV-DNA: 87%) than control group (I4Be Ag: 0%, HBV-DNA: 14%) after treatment. But there was no significant differenee in follow up period (36 & 43%: 17 & 25%, 1yr. after). 3) Loss of HRsAg was not observed in both groups. 4) Mild tolerable side effects were observed; fever (94%), myalgia (75%), headache (19%) and hair loss (13%). 5) Leukocytopenia (19%) and thrombocytopenia (19%) were transient. Conclusions: Prednisolone withdrawal followed by recombinant alpha-Interferon 2b therapy was effective for decreasements of serum aminotransferase activities, for the loss of HBeAg and HBV-DNA, and relatively safe for patients with CAH-B. But it is necessary for study with larger number of patients, more prolonged duration of follow up and more strict control study.
-
B형 만성 활동성 간염 환자에서 Prednisolone 단기이탈 및 Alpha Interferon 병합요법의 효과
이종선,김병호,성자원,허승식,이기천,정현용,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2
To evaluate the safety and efficacy of Pd withdrawal followed by recombinant alpha- Interferon 2b therapy. Nine patients were given a single daily subcutaneous injection of ^α-Interferon at a dose of 3 x 10 exp(6) units/day for first weeks and thrice weekly for next 15 weeks (maintenance) after pd tappered over 6 weeks. To evaluate the efficacy of therapy, we measured serum aminotransferase activities monthly during and after therapy, and also measured serm HBsAg, HBeAg and DNA probe before and after therapy. To evaluate the safety of therapy, all patients checked peripheral blood WBC, Hemoglobin, Platelet, BUN and Creatinine. The results were as follows : 1. In control group, the normalization of s-AST & ALT level, negative seroconversion of DNA probe & HBeAg were observed in 1/12(8%) & 7/10(17%), 0/10(0%) & 0/12(0%) at 6 months later, and maintained response in 1/11(9%) & 1/11(9%), 2/9(22%) & 2/11(18%) until 1 years later. 2. In treatment group, Serum AST and ALT returned to normal in 8/9 & 8/9 cases (89%) after 1 montns Tx. (mean serum AST : 33±8, ALT : 34±12 IU/ml) and maintained to normal response in 5/9(56%) & 6/9 cases(67%)after 6 months Tx. (mean s-AST : 55±43, ALT : 66±84 IU/ml), 3/9(33%) & 4/9 cases(44%) after 1 years Tx. It was statistically significant reponse except s-AST of after 1 years Tx. 3. In treatment group, s- HBeAg returned to normal in 3/9 cases(33%) after 1 months Tx., and maintained to normal response in 1/7 & 1/4 cases among follow up patients in after 6 & 12 months Tx. Serm DNA probe level were observed significantly negative seroconversion in 8/9 cases(89%) after 1 months Tx. (p<0.003), and maintained to negative response in 2/6 & 1/3 cases after 6 & 12 months Tx. 4. Serum AST, ALT, HBeAg and DNA probe were not significantly correlated with therapeutic response in relation to histologic diagnosis. 5. Fever and myalgia were noted in 9(100%) & 6(67%) cases. Headache, mild hair loss, anorexia, nausea, facial flushing & diarrhea were noted in few cases. Peripheral WBC(3cases) & platelet counts(3cases) were decreased transiently. This study shows that Pd withdrawal followed by recombinant alpha Interferon 2b therapy may be safe and effective in decrease the level of s-DNA probe, transaminase activity, loss of HBeAg and less adverse effect of clinical and hematologic examinations in patients with CAH type B. But it was necessary for study with large number of patients, more prolonged follow up duration and more strict control study.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
