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비방탈명산(秘方奪命散)의 항산화 ${\cdot}$ 항암 ${\cdot}$ 항균 효과 연구
한홍준,최정화,박수연,김종한,Han, Hong-Jun,Choi, Jeong-Hwa,Park, Su-Yeon,Kim, Jong-Han 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1
Objectives : This study was carried out to evaluate anti-oxidative, anti-microbial and anti-cancer effect for clinical application of Bibangtalmyungsan (BTS) Results : 1. The oxidative effects were measured by polyphenol, DPPH radical scavenging activity. BTS water extract was showed more effective than ethanol extract and also various solvent fractions from BTS water extract showed effective in the following order : ethyl acetate fraction > butanol fraction > hexane fraction ${\fallingdotseq}$ chloroform fraction ${\fallingdotseq}$ aqueous fraction 2. The results of anti-microbial effects were as follows. 1) Antibacterial activities of BTS extracts against Gram's negative and positive bacteria were ineffective 2) Antifungal activities of the BTS extracts against Aspergillus spp. , Trichohyton mentagrophyte KTCC 1077 were not effective. 3. The result of anti-cancer effects were as followings: 1) BTS ethanol extract was more effective than water extract against Caco-2, Calu-6, but it had cytotoxic effect against NIH3T3. 2) On the Caco-2, effective only in ethyl acetate $fraction(IC_{50}:$ 35.81 ${\mu}g/ml)$. 3) On the Calu-6, the most effective in ethyl acetate $fraction(IC_{50}:$ 189.65 ${\mu}g/ml)$ and effective In butanol $fraction(IC_{50}:$ 299.74 ${\mu}g/ml)$ and hexane $fraction(IC_{50}:$ 345.13 ${\mu}g/ml)$ 4) On the SUN-601, $IC_{50}$ value was within 80 ${\mu}g/ml$ in ethyl acetate fraction and hexane fraction. 5) On the HCT-1l6, the most effective in ethyl acetate $fraction(IC_{50}:$ 82.94 ${\mu}g/ml)$ and effective in hexane $fraction(IC_{50}:$ 374.56 ${\mu}g/ml)$. 6) On the AML-2/WT, the most effective in ethyl acetate $fraction(IC_{50}:$ 41.44 ${\mu}g/ml)$ and effective In hexane $fraction(IC_{50}:$ 303.01 ${\mu}g/ml)$. 7) On the NIH3T3, effective only in ethyl acetate $fraction(IC_{50}:$ 203.42 ${\mu}g/ml)$, but it was more ineffective than other cancer cells. Conclusion : These result suggest that BTS has antioxidative, antifungal activities and cytotoxic effects against Caco-2, Calu-6, SUN-601, HCT-116, AML-2/WT and NIH3T3, especially ethyl acetate fraction from water extract has more effective in antioxidative and anticancer effects.
Wagner Cementless Revision Stem을 이용한 인공 고관절 재치환술
한홍준(Hong Jun Han),김상수(Sang Soo Kim),최시호(Si Ho Choi) 대한고관절학회 1999 Hip and Pelvis Vol.11 No.3
The goals of revision surgery are to restore and maintain long-term mechanical stability and to pre-vent additional bone loss. We report the clinical and radiological results of revision surgery using the Wagner cementless revision stem. Thirty-seven Wagner revision stems were implanted between July 1989 and May 1999. We report the results of 34 hips with the follow-up of the minimum 1 year to the maximum 10 years(47 months in average). The causes of revision were aseptic loosening in 25 cases, septic loosening in six and periprosthetic fracture with loosening in three. Merle D’Aubigne score(12-point scale) based on pain and walking ability was used for the functional assessment. Radiological assessment which included regeneration and remodelling of bone at the stem-bone interface and sub-sidence of stem was done. 29 patients (85%) were satisfied with the postoperative outcome(>7 points), and 5 patients(15%) were unsatisfied (<6 points). The subsidence(>5mm) of Wagner stem was seen in 6 cases; 4 of these cases had to be re-revised because of pain and unstable hip joint. We found that the regeneration and remodelling of the bone were very good in eight cases(24%) and good in 20 cases(59%). As our short-term study results show, the Wagner cementless revision prosthesis seems to be very useful to obtain primary stable anchorage and remodelling of bone stock in revision surgery, especially in the patients with extensive proximal bone stock deficiency. Howeyer the prob-lem is subsidence, especially in patients with severe osteoporosis beyond the previous stem tip. To prevent subsidence, correct surgical technique, Sufficient period of non-weight bearing and prophy-lactic wiring are recommended.
한홍준 ( Hong Jun Han ),유정민 ( Jeong Min You ) 대한고관절학회 1998 Hip and Pelvis Vol.10 No.2
The pioneering work of Buchholz with gentamicin-loaded bone cement was a major breakthrough, making exchange arthroplasty for infected hips a preferred method to resection arthroplasty. Some guide lines have been established regarding the choice of a one- or two-stage exchange arthropalsty. The purpose of this study is to report the early clinical and radiological results of two-stage exchange arthroplasty for 7 infected hips(1 stage I, 2 stage II, 4 stage III), which has been performed since 1993. Joint aspiration and culture were carried out before operation. The most common causative organism was CNS(coagulase negative staphylococcus). Antibiotics(Cefamandole 2.0 gm or Erythromycin 0.5 gm plus Colistin 3 million I.U per 40 gm cement) loaded cement beads were left for average 4.5 months in the joint and medullary cavity after total removal of implant, capsule and granulation tissue. Systemic antibiotics were used for average 43 days. 3 cemented stems and 4 noncemented stems were reimplanted as a permanent prosthesis. 3 strut allografts for femur, and 1 bulk type and 2 morselized allografts for acetabulum were used to reconstruct the deficient bone stock at the time of second stage. No recurrence of infection or failed prosthesis was developed after average 2.5 years(minimum 1 year). Five were graded as having definitive cure of infection and two were graded as probable cure on both clinical and radiologic criteria(Weber). Harris hip score was increased from 47 points preoperatively to 85 points at last follow-up. Although the number of the patients was small, we think that we can take good results by two-stage exchange arthroplasty for infected THA.
Unusual Third-Body Wear에 의한 인공 고관절 전 치환술의 조기 실패 -3례보고-
한홍준 ( Hong Jun Han ),김정우 ( Joung Woo Kim ) 대한고관절학회 1998 Hip and Pelvis Vol.10 No.2
Two cases of severe osteolysis around the femoral stem and one case of early acetabular failure caused by third-body wear in Harris-Galante II cups(Zimmer, Warsaw, IN) are reported. These signs of loosening were detected 1 year, 4 years, 4 years and 10 months each after operation. At revisions, one or more triangular tynes of the metallie acetabular shell rim were found embedded in the polyethylene liners.