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증례 : 알레르기 ; 서혜부에 재발한 기무라씨 병 1예
한성환 ( Sung Hwahn Hahn ),한진형 ( Jin Hyung Han ),김경묵 ( Kyung Mook Kim ),김도형 ( Do Hyung Kim ),김윤섭 ( Youn Seup Kim ),박재석 ( Jae Seuk Park ),지영구 ( Young Koo Jee ) 대한내과학회 2011 대한내과학회지 Vol.80 No.6
기무라씨 병은 주로 젊은 동양인 남자에게서 다양한 부위에 무통성 종괴로 나타나지만 두경부 영역에 호발하며 양성경과를 띠는 것으로 알려져 있어 국내에서 장기적인 경과관찰이 이루어진 예가 드물다. 이에 병변의 발생이 드문 서혜부에 재발하여 수술적 절제 후 전신적으로 스테로이드를 투여하며 5년간 경과관찰 중인 여성 환자의 1예를 보고하는 바이다. Kimura disease is a rare chronic inflammatory disorder of unknown etiology, suggestive of an allergic or autoimmune mechanism, which presents mainly as soft tissue masses in the head and neck area in young Asian males. Blood tests show eosinophilia and an elevated immunoglobulin E; the typical pathologic findings are lymphoid follicular hyperplasia, interfollicular eosinophilic infiltration, and vascular hyperplasia. There is no standard treatment; surgical resection is preferred and systemic steroid or radiotherapy is used to treat disease relapses. Kimura disease in unusual sites has been reported, but there are few cases with long-term observations because of its benign nature. Here, we present the case of a female with recurrent Kimura disease; we follow her progress for about 5 years after surgical resection of masses in the right groin area, an unusual site, with a brief review of the literature. (Korean J Med 2011;80:745-750)
페그-인터페론과 리바비린 병합치료 중 발생한 간질성 페렴 및 범혈구 감소증
서지현 ( Ji Hyun Suh ),한성환 ( Sung Hwahn Hahn ),이지은 ( Ji Eun Lee ),한진형 ( Jin Hyung Han ),김경묵 ( Kyung Mook Kim ),김도형 ( Doh Hyung Kim ),김윤섭 ( Yon Seop Kim ),박재석 ( Jae Suk Park ),지영구 ( Young Koo Jee ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.1
The combination therapy of pegylated interferon and ribavirin is the mainstay of treatment for chronic hepatitis C patients. Anti-viral therapy is commonly associated with side effects such as headache, fever, myalgia, and arthralgia. However, anti-viral therapy can continue because these side effects are mostly mild and can be improved with supportive management. Anti-viral therapy should be stopped promptly if serious side effects, such as interstitial pneumonitis or hemolytic anemia occur, although those serious side effects are rare. There were a few case reports of interferon-related interstitial pneumonitis worldwide. In Korea, one atypical case report of interstitial pneumonitis has been reported, which followed the combination therapy of interferon-alpha and ribavirin in a patient with chronic hepatitis C. We present a case of interstitial pneumonitis and pancytopenia following the combination therapy of pegylated interferon and ribavirin in a patient with chronic hepatitis C.
A549 기도상피세포에서 IL-8 전사와 분비에 미치는 Dexamethasone과 Troglitazone의 병합투여효과
김남희 ( Nam Hee Kim ),이호연 ( Ho Youn Lee ),서지현 ( Ji Hyun Suh ),한성환 ( Sung Hwahn Hahn ),김도형 ( Doh Hyung Kim ),김윤섭 ( Youn Seop Kim ),박재석 ( Jae Seuk Park ),지영구 ( Young Koo Jee ) 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.4
Background: Glucocorticoid is a widely used anti-inflammatory agent in a variety of diseases. Recently, peroxisome proliferator activated receptor γ (PPARγ) ligand has been shown to exert a potential anti-inflammatory activity, mainly through their ability to down- regulate pro-inflammatory gene expressions. Objective This study was designed to evaluate the effects of co-treatment with dexamethasone and troglitazone (a ligand of PPARγ) on IL-8 transcription and secretion. Method: Steroid and troglitazone-induced transactivation was measured by using pGRE luciferase reporter gene in the A549 cell line. Steroid-induced transrepression was measured by using stable A549 IgG-NFκB luciferase cell line, which contained the minimal IL-8 promoter region. Result: Co-treatment with dexamethasone and troglitazone showed no additional increase of transactivation activity compared to dexamethasone single treatment. Suppressions of the transcriptional activity in the IL-8 promotor and IL-8 secretion showed no difference in the co-treatment with dexamethasone and troglitazone compared to those in dexamethasone single treatment. Conclusion: Our results suggest that co-treatment with PPARγ ligand and steroid may not have an additive anti-inflammatory activity at least in the airway epithelial cell. (Korean J Asthma Allergy Clin Immunol 2008;28:292-297)
기도상피세포에서 식물 에센셜 오일의 인터루킨-8 분비억제 효과
현경희 ( Kyung Hee Hyun ),김윤섭 ( Youn Seup Kim ),서정근 ( Jeung Keun Suh ),한성환 ( Sung Hwahn Hahn ),김도형 ( Do Hyung Kim ),박재석 ( Jae Suk Park ),지영구 ( Young Koo Jee ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4
Background: Neutrophil is an important inflammatory cell in severe asthma and associated with steroid-resistance in asthma therapy. In addition, interleukin (IL)-8 is a key chemokines recruiting and activating neutrophils. Methods: The aim of this study was to explore the therapeutic potential of aromatherapy using essential oils derived from plant extracts in asthma treatment. Essential oils from citron, pine tree, Chamaecyparis pisifera, and Chamaecyparis obtusa were extracted by water-steam distillation. The promoter activity and secretion of IL-8 were measured by using luciferase assay and enzyme-linked immunosorbent assay after pretreatment in tumor necrosis factor-α stimulated A549 and human bronchial epithelial cells (BEAS-2B) cell lines with diluted essential oils. Results: IL-8 transcription was suppressed with 1 : 500 concentration of each essential oil (P<0.05). IL-8 secretion in A549 cell was suppressed with 1 : 1,000 or higher concentrations of oils except from citron (P<0.05). IL-8 secretion in BEAS-2B cells was decreased after exposure to 1 : 500 concentration of pine tree, Chamaecyparis pisifera and 1 : 2,000 or higher concentrations of Chamaecyparis obtusa (P <0.05). Conclusion: Essential oils from pine tree and Chamaecyparis obtusa may have a therapeutic potential for asthma by regulating neutrophil-mediated inflammation. (Korean J Asthma Allergy Clin Immunol 2011;31:272-280)