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병원성 원생동물의 변이와 약물내성: Leishmania major의 클로로퀸 내성
전경희(Kyung Hee Jeune),정시련(See Ryun Chung),바바라 밀러(Barbara Miller),캐롤 시블리(Carol Sibley) 大韓藥學會 1991 약학회지 Vol.35 No.2
A comparative study was performed on two different strains of Leishmania majorchloroquine sensitive strains (ChlS) and its mutant chloroquine resistant strains (ChlR). ChlR strains were obtained at 5X10-4M chloroquine. Remarkable differences were observed at the initial chloroquine uptake in ChlR and ChlS, ie., the rate of uptake was very reduced in ChlR (Km values were 70nM and 125nM, respectively). Influx and accumulation of chloroquine were also compared between wild type and mutant. An increasing tendency in both influx and accumulation of chloroquine was shown in ChlS, but ChlR demonstrated a rapid release after a little uptake (influx) at the early stage. This result is thought to be basis of their resistance for ChlR strains.
병원성 원생동물의 병이와 약물내성 : Leishmania major의 클로로퀸 내성 Chloroquine Resistance in Leishmania major
전경희,정시련,바바라 밀러,캐롤 시블리 영남대학교 약품개발연구소 1991 영남대학교 약품개발연구소 연구업적집 Vol.1 No.-
A comparative study was peformed on two different strains of Leishmania major, chloroquine sensitive strains (Chl^(S)) and its mutant chloroquine resistant strains (Chl^(R)). Chl^(R) strains were obtained at 5×10^(-4) M chloroquine. Remarkable differences were observed at the initial chloroquine uptake in Chl^(R) and Chl^(S), i.e., the rate of uptake was very reduced in Chl^(R) (Km values were 70 nM and 125 nM, respectively). Influx and accumulation of chloroquine were also compared between wild type and mutant. An increasing tendency in both influx and accumulation of chloroquine was shown in Chl^(S), but Chl^(R) demonstrated a rapid release after a little uptake (influx) at the early stage. This result is thought to be basis of their resistance for Chl^(R) strains.