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천왕보심단(天王補心丹) 열수추출물(熱水抽出物), 초미세분말제형(超微細粉末劑形)이 Alzheimer`s Disease 병태(病態) 모델에 미치는 영향(影響)
최강욱 ( Kang Wook Choi ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.2
Objective : This experiment was designed to investigate the effect of the CBD hot water extract & ultra-fine Powder on Alzheimer`s Disease Model Induced by βA. Method : The effects of the CBD hot water extract on expression of interleukin-1 beta(IL-1β), TNF-α mRNA and production of IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide(LPS). The effects of the CBD hot water extract & ultra-fine powder on (1) the behavior (2) expression of IL-1β, tumor necrosis factor-alpha(TNF-α), (3) the infarction area of the hippocampus in Alzheimer`s diseased mice induced with βA were investigated. Result : The CBD hot water extract suppressed the expression of IL-1β, TNF-α mRNA in BV2 microglia cell line treated with LPS. The CBD hot water extract significantly suppressed the production of IL-1β, TNF-α in BV2 microglial cell line treated with LPS. The CBD hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer`s disease induced by βA in the Morris water maze experiment, which measured step-through latency and distance movement-through latency. The CBD hot water extract & ultra-fine powder significantly suppressed the expression of IL-1β and TNF-α protein in the microglial cell of mice with Alzheimer`s disease induced by βA. The CBD hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer`s disease induced by βA. The CBD hot water extract & ultra-fine powder reduced infarction area of hippocampus, in the mice with Alzheimer`s disease induced by βA. Conclusions : These results suggest that the CBD hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer`s disease. Investigation into the clinical use of the CBD hot water extract & ultra-fine powder for Alzheimer`s disease is suggested for future research.
치매단계평가검사의 유용성과 연관성에 대한 임상연구 -청주 지역사회 치매환자를 중심으로
최강욱 ( Kang Wook Choi ),임정화 ( Jung Wha Lim ),정인철 ( In Chul Jung ),이상룡 ( Sang Ryong Lee ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.3
Objective : This study was to investigate the utility and relation of dementia rating test(K-DRS and IADl, NPI-Q(symptom), NPI-Q(suffering), CCDR, SDS Method : For this study, we carried out dementia assessment examination of 34 patients with memory disturbance who have come to Cheongju oriental hospital of Daejeon university from April 2005 to February 2006. This study classified the patients as none-dementia(ND), questionable dementia(QD), and dementia(DA) groups and analyzed the result of examination. Results : 1. K-DRS and SDS, K-DRS and SDS, NPI-Q(symptom) and NPI-Q(suffering), NPI-Q(symptom) and CCDR showed clear correlations statistically each other.2. K-DRS scores showed the significant differences from that of ND and the other groups ; attention and conceptualization showed the significant differences between ND and DA, management and memorization showed the significant differences between DA and the other groups.3. IADL scores showed the significant differences from that of DA and the other groups, NPI-Q(symptom) scores showed the significant differences between QD and DA, NPI-Q(suffering) scores showed no differences among all groups.4. CCDR scores showed the significant differences from that of DA and the other groups, SDS scores showed the significant differences between ND and DA.5. MMSE-K and K-DRS showed strong correlations statistically each other. Conclusion : The study results suggest that dementia rating tests is useful to esteem the dementia and the dementia rating tests have strong corelations each other. We use the above mentioned tests for correct diagnosis.
독서요법과 뉴로피드백을 시행한 심비양허형(心脾兩虛型) 울증(鬱證)환자 치험(治驗) 1례(例)
임정화 ( Jung Hwa Lim ),최강욱 ( Kang Wook Choi ),정인철 ( In Chul Jung ),이상룡 ( Sang Ryong Lee ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.2
Bibliotherapy is the field of clinical counceling to treat the emotional, psychiatric and social maladjustment. Neurofeedback is a means by which participants can learn voluntary control of the EEG and has been applied to a range of clinical conditions such as epilepsy, attention deficit hyperactivity disorder, depressive disorder. ``Ul-zeong`` comes from obstruction of qi by stress. The mind affect the body. The patient has depressed mood, irritable sign, chest discomfort, flank pain, angry state and some strange feeling on the throat. In this case, a female patient, 30 years old, who complained of amnesia, deficiency of the power of the attention and concentration depersonalization, depressed mood, insomnia ect. We treated the patient with bibliotherapy, neurofeedback and oriental medical treatment such as heral medicine, acupuncture treatment and aroma therapy. In result, the symptoms which she complained were improved.
정인철 ( In Chul Jung ),이상룡 ( Sang Ryong Lee ),박양춘 ( Yang Chun Park ),홍권의 ( Kwon Eui Hong ),이용구 ( Young Koo Lee ),강위창 ( Wee Chang Kang ),최선미 ( Sun Mi Choi ),김종우 ( Jong Woo Kim ),최강욱 ( Kang Wook Choi ),오달 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.1
Objective : The purpose of this research is to examine the effect of Simjeongkyeok Sa-am acupuncture treatment for major symptoms of Hwa-byung. Method : In this randomized, single blind, placebo-controlled study, we compared Simjeongkyeok acupuncture with Sham acupuncture in the treatment for major symptoms of Hwa-byung. Likert scale for major symptom of Hwa-byung was measured as the 1st evaluative instrument, and STAXI-K, STAI-K, BDI-K and HRV were also measured as the 2nd evaluative instrument at the before treatment and after treatment. Results : In comparison of Likert scale for major symptoms, total score of after treatment decreased significantly at each point on both groups, but there was no significant difference between both groups. In comparison of STAXI-K, STAI-K, BDI-K, there was no significant difference in variation of score between both groups. But Simjeongkyeok group showed higher ratio variation of STAXI expression than that of Sham group, Also on subjects whose main complaint symptom were burning sensation and whose pattern identification were Qizhi, Simjeongkyeok group showed higher variation of Likert scale score and BDI-K than that of Sham group. The significance was border line around. Conclusion : We considered that Shimjeongkeok treatment will be likely to be recommended for treating Hwa-byung, especially on subjects in each group whose main complaint symptom were burning sensation or whose pattern identification were Qizhi. Also it may also be effective on the management of anger expression.