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생화학적 마커와 Microsatellite 마커를 이용한 KCR 랫드의 유전모니터링
박한진(Han-Jin Park),이철호(Chul-Ho Lee),차달선(Dal-Seon Cha),조재우(Jae-Woo Cho),조규혁(Kyu-Hyuk Cho),최양규(Yang-Kyu Choi),현병화(Byung-Hwa Hyun),조진원(Jin-Won Cho),한상섭(Sang-Seop Han),송창우(Chang-Woo Song) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.2
The cataract mutant rat which showed lens opacity was found in the colony of Sprague-Dawley rat at Korea Research Institute of Chemical Technology (KRICT) in 1996. The mode of inheritance of affected rats was autosomal recessive. These cataractous rats were mated by sister and brother to 27th (F₂₇) generation and named as Korea Cataract Rat (KCR). We performed genetic monitoring of KCR rat using biochemical and microsatellite markers to determine their genetic identified homozygous and distinctive genetic profile. In biochemical monitoring, six rats from each of the F₁₈/F₁₉F₂₀ were tested using 13 biochemical markers. In molecular genetic monitoring, nine rats from the F₂₅ and F₂₆ were tested using 13 microsatellite markers. No differences were found among the genetic profiles of the F₁₈/F₁₉F₂₀ in biochemical monitoring. Also, in the molecular genetic monitoring, we identified that both genetic profiles of F₂₅ and F₂₆ were the same. The genetic profile of KCR rats was unique against the other major rat strains. In addition, the polymorphysm of KCR rat for microsatellite markers was different from the other strains. These results suggest that KCR rat is genetically well qualified as far as in this test and it has been well established as a new inbred strain which has a novel genetic profile and cataract trait.
말기신부전 환자의 혈액투석에 있어서 혈관 성숙기간이 동정맥루 생존율에 미치는 영향
박규용(Ky Yong Park),김근호(Guen Ho Kim),김형직(Hyung Jik Kim),채동완(Dong Wan Chae),노정우(Jung Woo Noh),구자룡(Ja Ryong Koo),조진원(Jin Won Cho),여미애(Mi Ae Yeo),양형원(Hyung Won Yang),김경희(Kyung Hee Kim),이기성(Ki Sung Lee),전로원 대한내과학회 1999 대한내과학회지 Vol.57 No.1
Arteriovenous fistula(AVF) has been the most important, primary mode of achieving vascular access for chronic hemodialysis by this time. In general, maturation period over 4 to 8 weeks after operation for the formation of AVF has been recommended for the long-term survival of AVF, and so insertion of central venous catheter without using AVF being matured has been primarily recommended whenever hemodialysis is needed. But not infrequently, serious complications have been reported in association with the insertion and the use of central venous catheter. So earlier use of AVF is regarded as a good method of avoiding serious complications with regard to the insertion and the use of central venous catheter. But early use of AVF has not been generally recommended, for early use of AVF has been regarded to be associated with early failure of AVF. But few studies have reported the correlation between maturation period and AVF survival. And in practice, early use of AVF has already been performed frequently by not a few nephrologists or nurses of dialysis units. So authors tried to examine the correlation between maturation period and AVF survival rate, and to find the validity of early use of AVF if it is regarded usable for the hemodialysis by experienced hemodialysis nurses and nephrologists. Methods : A retrospective analysis using 88 AVF cases which had been created in 85 patients from Oct. 1986 through June 1996, and from which authors could get enough information for this study was done. Authors compared one year survival rates of AVF according to the maturation period, the presence of DM, and condition of AVF assessed clinically by doctors and experienced nurses in hemodialysis units. Also from the cases with AVF obstruction, authors examined the 1st, 2nd, and 3rd year survival rate of AVF according to the maturation period. Results : One year survival rate of AVF with maturation period less than 4 weeks was higher than that with maturation period more than 4 weeks, but there was no statistical significance. One year survival rate, irrespective of the length of maturation period for AVFs, of AVF regarded to be usable and good for hemodialysis was higher than that of AVF regarded to be usable but not good for hemodialysis. In the study with the AVF obstruction group only, one year survival rate of AVF with maturation period less than 4 weeks was higher than that of AVF with maturation period more than 4 weeks but there was no statistical significance. And one year AVF survival rate was higher in non DM group(94.1%) than DM group(60%) regardless of maturation period of AVF(P<0.05). Conclusion : On the contrary to the views that longer maturation period of more than 4 weeks will be necessary for the long-term survival of AVF, our results suggest that shorter maturation period for AVF less than 4 weeks does not necessarily mean early failure of AVF once AVF is regarded to be usable for hemodialysis. So it is suggested that early use of AVF instead of inserting central venous catheter is a reasonable approach for getting an adequate vascular access for hemodialysis in chronic renal failure patients who were subjected to receive hemodialysis on waiting peroid of AVF maturation.