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Alcohol의 麻醉作用에 미치는 Iproniazid 및 Reserpine의 影響
趙鍾國 고려대학교 의과대학 1979 고려대 의대 잡지 Vol.16 No.1
In order to investigate the influences of iproniazid and reserpine on the anesthetic effect of ethyl alcohol in rabbits, the induction time, anesthetic time, recovery time and total time of the anesthesia induced with ethyl alcohol i.p. injection in rabbits pretreated with iproniazid and reserpine, respectively, was measured, with references to the periodic changes of blood alcohol concentration and blood sugar levels. The results were obtained as follows; 1. The anesthetic time of the ethyl alchol anesthesia was slightly reduced by the iproniazid pretreatment, but the anesthetic time was markedly prolongated by the reserpine pretreatment. 2. The blood alcohol concentration was increased to the peak level one hour after alcohol injection, but after that, the concentration was rapidly decreased. And then, by the iproniazid or reserpine pretrcatment, the tendency of the rapid decrease was so markedly suppressed that the high level of the blood alcohol concentration was persisted. 3. The hypoglycemic effect of ethyl alcohol was markedly potentiated by the iproniazid pretreatment, but the hypoglycemic effect was markedly inhibited by the reserpine pretreatment.
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Pentazocine과 Morphine에 依한 組織內 Catecholamine 含量 및 血漿 Corticosterone變動에 對한 Naloxone의 影響
趙鍾國,千然淑,申萬鍊 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.1
Opioids-induced analgesia is due to actions at several sites within the CNS and involves several systems of neurotransmitters. In this paper, the influences of naloxone on the changes of brain and cardiac norepinephrine(NE) contents and plasma corticosterone induced by pentazocine and morphine in mice were studied. The results obtained were summarized as follows: 1. Brain and cardiac NE contents were markedly decreased by 60㎎/㎏ of pentazocine given intraperitoneally, but not affected by 30㎎/㎏ and 60㎎/㎏ of pentazocine given. 2. Brain and cardiac NE contents were markedly decreased by 20㎎/㎏ of morphine given intraperitoneally, but not affected by 10㎎/㎏. And plasma corticosterone levels were markedly increased by 10㎎/㎏ and 20㎎/㎏ of morphine given. 3. Naloxone antagonized the decreases of brain and cardiac NE contents induced by pentazocine, but not antagonized the increases of plasma corticosterone levels. 4. Naloxone completely antagonized the decreases of brain and cardiac NE contents and increases of plasma corticosterone levels induced by morphine. 5. Brain and cardiac NE contents were markedly decreased and plasma corticosterone levels were markedly increased by intraperitoneal injection twice daily for 7days of pentazocine in increasing doses from 30 to 60㎎/㎏ per injection, and naloxone did not antagonized, the changes of tissue NE contents and plasma corticosterone levels induced by pentazocine. 6. These changes in tissue NE contents and plasma corticosterone levels were no longer seen by intraperitoneal injection twice daily for 7days of morphine in increasing doses from 10 to 20㎎/㎏ per injection.
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