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조수철,서유헌,김헌식,Cho, Soo-Churl,Suh, Yoo-Hun,Kim, Hun-Sik 대한소아청소년정신의학회 1991 소아청소년정신의학 Vol.2 No.1
유아자폐증의 생화학적인 원인중의 일부를 규명하기 위하여 전형적 유아자폐증 37명, 비전형 유아자폐증 26명, 대조군 23명을 대상으로 하여 혈장 DBH활성도를 측정하고, DBH 활성도와 연령 또는 정신병리와의 상관관계를 연구한 결과 다음과 같은 결과를 얻었다. 1) 혈장 DBH 활성도는 전형적 유아자폐증군에서 대조군에 비하여 현저히 높았으며, 전반적 발달 장애군(전형적 유아자폐증+비전형 유아자폐증)에서 대조군에 비하여 뚜렷이 높았다. 2) 혈장 DBH 활성도의 연령에 따른 변화는 비전형 유아자폐증군과 대조군에서는 연령이 증가됨에 뚜렷이 증가되는 양상을 보였으나, 전형적 유아자폐증군에서는 의미있는 상관관계가 관찰되지 않았다. 3) 혈정 DBH 활성도와 정신병리간의 상관관계는 의미있는 관계가 관찰되지 않았다. 이러한 결과로 미루어, 유아자폐증의 생화학적인 원인중의 일부로서 Catecholamine계가 관여하고 있을 가능성을 시사할 수 있으며, 이는 DBH의 개체발생적인 과정에서의 장애때문인 것으로 생각된다. Plasma $dopamine-{\beta}-hydroxylase(DBH)$ activity was measured in 37 autistic disorders, 26 atypical pervasive developmental disorders and 23 controls, to elucidate the biological etiology in pervasive developmental disorders. The results are summarized as follows : 1) In the autistic group, the mean plasma DBH activity was significantly elevated compared to the atypical and control groups. The mean plasma DBH activity was also significantly elevated in pervasive developmental disorders(autistic disorder+atypical developmental disorder) compared to control group. 2) In the atypical and control groups, the DBH activity significantly increased with age, but in the autistic group, the DBH activity was not significantly correlated with age. 3) No significant correlation was found between the DBH activity and the severity of psychopathology. These findings support the hypothesis of a possible involvement of brain catecholamine dysfunction in the production of autistic symptoms, and this dysfunction might be due to the abnormal ontogenetic process of DBH activity in autistic disorders.
한국인 주의력결핍-과잉행동장애 아동의 세로토닌 수송체 유전자 다형성
조수철,손정우,김붕년,김재원,유희정,황준원,조대연,정운선,박태원,Cho, Soo-Churl,Son, Jung-Woo,Kim, Boong-Nyun,Kim, Jae-Won,Yoo, Hee-Jeong,Hwang, Jun-Won,Cho, Dae-Yeon,Chung, Un-Sun,Park, Tae-Won 대한생물정신의학회 2009 생물정신의학 Vol.16 No.1
Objectives : The aim of this study was to investigate the association between Korean ADHD patients and the l/s polymorphism of serotonin transporter(5-HTTLPR). Methods : The study sample consisted of 189 Korean ADHD children diagnosed by Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version(K-SADS-PL), both parents of ADHD children, and 150 normal children. DNA were extracted from the blood of all samples, and genotyping was done. Based on the allele and genotype information, not only the case-control analysis between ADHD and normal children but also the family-based association test among ADHD children and their parents. Transmission disequilibrium test(TDT) were performed for family-based associated test(number of trio=113). The results of the clinical rating and neuropsychological tests were compared according to the l/s genotype of ADHD children. Results : In case-control analysis, there were no statistically significant difference of l/s gene polymorphism between ADHD and normal children in various kinds of analysis condition. In family-based association study, TDT failed to detect linkage disequilibrium between l/s gene polymorphism and ADHD in whole ADHD families. However, in the families of ADHD inattentive type only(number of trio=23), I allele was transmitted more preferentially in the proband with ADHD even if the number of families was small(${\chi}^2$=4.57, p=.032). In the analysis of the results from the clinical scales and neuropsychological tests in ADHD children, the score of the Novelty- Seeking of ADHD children with l/l genotype was significantly lower than with the other genotypes(F=3.15, p=.047), and that of Self Transcendence was significantly higher(F=4.25, p=.017). Conclusion : The results of this study suggest there were no significant genetic association between the 5- HTTLPR gene polymorphism and Korean ADHD.
조수철(Soo Churl Cho) 대한신경정신의학회 2021 신경정신의학 Vol.60 No.1
The main purpose of this study was to develop an ideal model to take good care of mentally ill soldiers and strengthen the fighting power of the Korean military. This paper is based on the author’s life-long personal experience on education, research, and clinical services in the field of psychiatry and military psychiatry. The final ideal model is the “Model of Everything.” This model is the integration of the bio-psycho-socio-spiritual model and positive psychiatry. This model can be exemplified as follows: objects, bio-psycho-socio-spiritual aspects; time, past-present-future; space, I-family-society-nation-world-cosmos; attitudes, positive-historical-scientific-artistic-philosophical. This model can be an ideal model for mentally ill soldiers because it helps to take care of them as a “whole, entire person” rather than the diseases or disorders themselves. The ‘Model of Everything’ means that it can be applied to not only psychiatry but also to all academic fields, including politics, economics, social sciences, natural sciences, and culturology.