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조성익,강삼식,김경란,김태희,이은방,Cho, Sung-Ig,Kang, Sam-Sik,Kim, Kyung-Ran,Kim, Tae-Hee,Lee, Eun-Bang 한국생약학회 1999 생약학회지 Vol.30 No.2
Torilin was isolated from haxane fraction of Torilis Fructus extract. Torilin produced inhibition of the acetic acid-induced and phenylquinone-induced writhing syndrome at the oral doses of 30 and 90 mg/kg in mice. It also increased the pain threshold at the oral doses of 30, 90 and 270 mg/kg in the tail pressure method and the Randall-Selitto method. However, it did not show a hypothermic action at the oral doses of 30 and 90 mg/kg in mice. The compound exhibited strong anticarrageenan activity at the oral doses of 90 and 270 mg/kg in rats, and had inhibitory effect on the vascular permeability at the oral doses of 30 and 90 mg/kg in mice. It also showed potent inhibition of leucocyte emigration in CMC-pouch at the doses of 3 and 9 mg/rat, sc. The acute toxicity of torilin was very weak: the $LD_{50}$ values were more than 5000 mg/kg, po and 2000 mg/kg, ip in mice. From the above mentioned results, it was suggested that torilin had potent analgesic and anti-inflammatory activities.
조성익(Sung Ig Cho),이은방(Eun Bang Lee),조태순(Tae Soon Cho) 한국생약학회 1985 생약학회지 Vol.16 No.1
The MeOH extracts obtained from Glehniae Radix and Arisaematis Rhizoma were investigated for the acute toxicities, the effects on the CNS and the antiinflammatory action. The results are as follows: 1) The acute toxicities of each extract were very weak; their LD_(50) were more than 6,000 ㎎/㎏, p.o. and 2,000㎎/㎏, i.p. 2) The extract of Glehniae Radix at a dose of 2,000㎎/㎏, p.o. did not show any sedative, anticonvulsive, analgesic and hypothermic effect, however, it prolonged the hexobarbital induced hypnosis and exhibited the antipyretic effect in mice. 3) The extract of Arisaematis Rhizoma at a dose of 2,000㎎/㎏, p.o. did not show any sedative, anticonvulsive, analgesic, hypothermic, anal antipyretic effect in mice. 4) The extract of Glehniae Radix showed significant inhibition of polymorphs emigration the CMC-pouch at a dose of 200㎎/rat, s.c., however, the extract of Arisaematis Rhizoma did not show the effect at a dose of 200㎎/rat, s.c. 5) The extracts of the two plants at the each dose of 1, 500㎎/㎏, p.o. and 3, 000㎎/㎏, p.o. showed no antiinflammatory action in the carrageenin induced paw edema in rats. From above mentioned results, it was found that the MeOH extract of Gleheiae Radix has the hexobarbital induced hypnosis prolongation effect, the antipyretic effect and the antiinflammatory effect in the acute model of leucocyte emigration, however, the extract of Arisaematis Rhizoma did not show any effect at the dose of the experiments performed.
조태순(Tai Soon Cho),이선미(Sun Mee Lee),이은방(Eun Bang Lee),조성익(Sung Ig Cho),김용기(Yong Kee Kim),신대희(Dae Hee Shin),박대규(Dai Kyu Park) 대한약학회 1999 약학회지 Vol.43 No.2
In order to investigate pharmacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH) and Wonbang Woohwangchungsimwon Pill (SCH), the effects of NSCH and SCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in mongolian gerbils. The histological observations showed preventive effects of NSCH and SCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by SCH treatment. In contrast to what was seen with ATP, lipid peroxide were elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NSCH and SCH treatments. While NSCH and SCH had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by electric shock and strychnine. NSCH and SCH showed sedative effect in rotarod and spontaneous activity test. Furthermore, NSCH and SCH showed anti-stress effect. Our findings suggest that the pharmacological profiles of NSCH on cerebral ischemia and central nervous system are similar to those of SCH.
조태순(Tai Soon Cho),이종찬(Jong Chan Lee),조성익(Sung Ig Cho),이선미(Sun Mee Lee) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.3
This study was done to investigate whether cholic acid derivatives have anti-stress activity in various stress models. Two cholic acid derivatives, ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA), were used. Physical, psychological, chemical and environmental stress models were performed. Adrenal weight, serum glucose levels and ALP activity were elevated in restraint stress model, but this elevation was prevented by UDCA treatment. Moreover, UDCA and TUDCA inhibited exploratory and spontaneous movements in oscillation stress model. In alcohol-induced stress model, TUDCA improved rotarod performance. UDCA and TUDCA significantly reduced the involution of lymphoid organs and the increment of WBC counts in cold stress model. These findings suggest that cholic acid derivatives have anti-stress effects in various stress models.
조태순(Tai Soon Cho),이선미(Sun Mee Lee),이은방(Eun Bang Lee),조성익(Sung Ig Cho),김용기(Yong Kee Kim),신대희(Dae Hee Shin),박대규(Dai Kyu Park) 대한약학회 1997 약학회지 Vol.41 No.6
In order to investigate pharmacological properties of New Woohwangchungsimwon Pill (NWCH) and Woohwangchungsimwon Pill(WCH), effects of NWCH and WCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in Mongolian gerbils. The histological observations showed preventive effect of NWCH and WCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by NWCH and WCH treatment. In contrast to what was seen with ATP, the lactate and lipid peroxide were both elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NWCH and WCH treatments. In central nervous system, NWCH and WCH had sedative effect in rotarod and spontaneous activity test, but no effects on the hexobarbital-induced sleeping time. And, NWCH and WCH had weak anticonvulsion effects in electric shock- and pentetrazol-induced convulsion test. NWCH and WCH increased the respiration rate, but decreased the respiration depth in rats. Furthermore, NWCH and WCH showed antistress effect. Our findings suggest that the pharmacological profiles of NWCH on cerebral ischemia and central nervous system are similar to that of WCH.
l-Muscone 의 뇌허혈 및 중추신경계에 관한 약효연구
조태순(Tai Soon Cho),이선미(Sun Mee Lee),이은방(Eun Bang Lee),조성익(Sung Ig Cho),김용기(Yong Kee Kim),신대희(Dae Hee Shin),박대규(Dai Kyu Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3
In order to investigate pharmacological properties of l-muscone, effects of l-muscone and musk on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in Mongolian gerbils. The histological observations showed a preventive effect of the l-muscone treatment with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by the l-muscone treatment. In contrast to what was seen with ATP, the lactate and lipid peroxide were both elevated in vehicle-treated ischemic gerbils: This elevation was prevented by the l-muscone treatment. While l-muscone had no effects on the hexobarbital-induced sleeping time and the convulsions induced by electric shock, pentetrazol and strychnine, it had effect on rotarod test and spontaneous activity test. Respiration rate and depth were increased by the l-muscone treatment. Furthermore, l-muscone showed anti-stress effect. Our findings suggest that the pharmacological profile of l-muscone on cerebral ischemia and central nervous system are similar to that of musk.
이은방(Eun Bang Lee),조성익(Sung Ig Cho),이대위(Da Wei Li),현진이(Jin Ee Hyun) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.3
N/A DKY is an oriental drug preparation composed of 17 natural products and is known to have antihyperglycemic action at 100 ㎎/㎏ po in animal tests. The general pharmacological properties of DKY preparation were investigate in mice, rats, guinea pigs and rabbits. This preparation did neither show any effects on central nervous system, nor effects on algesia, nor epilepsia at the large doses of 3000 ㎎/㎏ po in mice or rats. However, the preparation showed hypothermic action at the doses of 330 and 1000 ㎎/㎏ po. In the guinea pig ileum, rat fundus strip and estrogenized rat uterus, DKY did not influence their tension at a concentration of 3 X 10^(-3) g/㎖, and the spasmogenic actions produced by histamine, ACh and 5-HT were not blocked in the presence of DKY at 3 × 10^(-3) g/㎖. The blood pressure and respiration were not considerably influenced at 10㎎/㎏ iv of DKY in rabbits. It did not influence the intestinal propulsion of mice and the normal gastric secretion of rats. These results may suggest that DKY preparation have little effects on central nervous, autonomic and gastrointestimal systems, except hypothermic action.
유전자 재조합 Erythropoietin (LB-00014) 의 일반약리작용
이은방(Eun Bang Lee),천선아(Seon Ah Cheon),이향주(Hyang Joo Lee),조성익(Sung Ig Cho),손지영(Jee Young Sohn) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
General pharmacological properties of LB-00014, an erythropoietin which was produced by recombinant DNA technique in Biotech Research Institute, LG Chemical Ltd. were examined. The administration of LB-00014 (60, 600, 6000 IU/㎏, iv) in mice had no effect in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazole solution. LB-00014 (60, 600, 6000 IU/㎏, iv) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration rates, and it did not influence the responses produced by injection of acetylcholine or epinephrne. The administration of LB-00014 (601, 600, 6000 IU/㎏, iv) in rats had no effect on the plasma prothrombin time, activated partial thromboplastin time and hemolytic action. The platelet aggregation induced by collagen in human plasma was not influenced by LB-00014 (10, 100, 1000 IU/㎏, iv). It showed no direct effect at 100 and 1000IU/ml in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also had no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence gastric secretion, pH and acid output at 6000 IU/㎏, iv in rats, but showed a significant increase in intestinal propulsion of mice at 6000 IU/㎏, iv. Its administration (60, 600, 6000 IU/㎏, iv) caused no effect on urine and electrolyte excretion in rats. These results indicate that LB-00014 does not exsert any of serious pharmacological effects.
김용기(Yong Kee Kim),이선미(Sun Mee Lee),조태순(Tai Soon Cho),이은방(Eun Bang Lee),조성익(Sung Ig Cho),신대희(Dae Hee Shin),박대규(Dai Kyu Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.4
In order to investigate pharmacological properties of New Woohwangchungsimwon Liquid (NCL) and Woohwangchungsimwon Liquid (CL), effects of NCL and CL on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in Mongolian gerbils. The histological observations showed a preventive effect of NCL and CL treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by CL treatment. In contrast to what was seen with ATP, the lactate and lipid peroxide were both elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NCL and CL treatments. While NCL and CL had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by electric shock and pentetrazol. NCL and CL showed sedative effect in rotarod and spontaneous activity test. Respiration rate and depth were increased at the high dose of NCL and CL. Furthermore, NCL and CL showed anti-stress effect. Our findings suggest that the pharmacological profile of NCL on cerebral ischemia and central nervous system are similar to that of CL.