http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
조승일,제갈문영,옥보람,김보경,권미리,강우열,성숙진,김현주,이혜원,윤영란 대한임상약리학회 2017 Translational and Clinical Pharmacology Vol.25 No.2
This study describes the development of an analytical method to determine sumatriptan levels inhuman plasma using high performance liquid chromatography (HPLC) coupled with triple quadrupoletandem mass spectrometry (MS/MS) and its application to a pharmacokinetic study inhealthy Korean volunteers. A single 50 mg dose of sumatriptan was orally administered to twelvehealthy volunteers (nine women and three men). The HPLC-MS/MS analytical method was validatedwith respect to its specificity, linearity, sensitivity, accuracy, precision, recovery, and stability. The calibration curve was linear over a concentration range of 0.3–100 ng/mL (r > 0.999). Thelower limit of quantitation for sumatriptan in plasma was 0.3 ng/mL. The accuracy and precision ofthe analytical method were acceptable within 15% at all quality control levels. We compared plasmaconcentration-time curves as well as pharmacokinetic parameters such as the area under the curve(AUC) and maximum plasma concentration (Cmax). Both the mean AUC and Cmax of sumatriptanwere 1.56 times higher in women than in men. These differences could be largely explained by thedifference in body weight (44%) between women and men. The outcomes may provide insights intodeveloping appropriate individualized treatment strategies.