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위 십이지장질환 환자들의 위액내 Fungus 에 관한 연구
정정명(Jung Myung Chung),박주열(Joo Youl Park),문기석(Key Seack Moon),김병제(Byoung Je Kim),김동민(Dong Min Kim),최하진(Ha Jin Choi) 대한내과학회 1986 대한내과학회지 Vol.31 No.1
N/A It is widely known that with recent environmental changes and improved methods of diagnosis, infection of fungi in a number of human organ is steadily increasing. Despite a few reports made by scientists on the relationship between candida infection and gastroenteric diseases, the infection and growth of fungi in a stomach and gastric juices has been seldom reported. In cases of gastric and duodenal disease, however, enviornmental changes within a stomach such as changes of gastric juices, disturbances of gastric motility and impairment of gastric mucosa are likely to come about, it can, therefore, be assumed that the growth of various fungi in a stomach and gastric juices is possible. Recently we have investigated the fungal infection in gastric juices aspirated from various gastroduodenal disease patients and obtained following results. 1) 40 patients have vague epigastric pain complaints for a long duration, although no definite pathological findings are endoscopically recognizable in stomach and duodenum, 16 duodenal ulcer patients, 30 gastric ulcer patients and 30 stomach cancer patients were studied on fungal growth in their salivas and gastric juices aspirated from their mouth and stomach. 2) pH of gastric juices from 21 patients in whom fungus was grown in their stomach aspirates was 4.85±1.45, whereas pH of gastric juices from another 21 patients in whom no fungus was grown was 1.91±0.61. A rather striking difference in their acidity between those 2 groups is recognizable, as already reported previously, 3) The frequency of fungal growth in gastric juices was found in following order. 32.5% of cases of non-ulcer, non-cancer patients, 18.8% of cases of duodenal ulcer patients, 73.3% of cases of gastric ulcer patients, and 83.3% of cases of stomach cancer patients. Among those patients who have fungal growth in their gastric juice, candida was found. 25.0% of cases of non-ulcer, non-cancer patients 6.3% of cases of duodenal ulcer patients, 60.0% of cases of gastric ulcer patients, and 70.0% of cases of stomach cancer patients. It was revealed that the frequency was rather higher in gastric ulcer and stomach cancer patients than in duodenal ulcer and non-ulcer, non-cancer patients. 4) Ten non-ulcer, non-cancer patients who had fungal growth in their gastric aspirates were, 6 cases of acute gastroenteritis, 2 cases of cirrhosis, 1 case of Parkinson's disease, and 1 case of renal stone.
위 십이지장 질환들의 위액내 Bile Acid 와 Lysolecithin 농도에 관한 관찰
정정명(Jung Myung Chung),정봉균(Bong Kun Jeon),김수찬(Soo Chan Kim),주영돈(Young Don Joo),설상영(Sang Young Soel),최하진(Ha Jin Choi) 대한내과학회 1989 대한내과학회지 Vol.37 No.3
N/A A peptic ulcer is a benign ulcerative lesion in the alimentary tract developed by corrosive and digestive action of acid and pepsin in gastric juice and its cause is thought to be due to the imbalance of aggressive factors and defense mechanisms in gastric juice. But there are many controversies about the etiologic factors of peptic ulcer and further studies are needed for understanding of the pathophysiologic mechanisms. Recently it has been reported that bile and pancreatic juice could be refluxed into the upper duodenum or stomach under certain conditions, so gastric and duodenal ulcers could be induced by those digestive actions. This reflux phenomenon is supposed to be an important etiologic factor of gastric ulcer. More specifically, bile acid and lysolecithin of the refluxed duodenal contents increase back diffusion of hydrogen ions in the stomach and this back diffusion of hydrogen ions could induce acute or chronic gastritis and gastric ulcer. Moreover, it is carefully presumed that this reflux-induced acute and chronic gastritis acts as a factor of non-ulcer dyspepsia, and chronic stimulation of refluxed bile acid and lysolecithin seems likely to be an etiological factor for the development of stump cancer in gastrectomized patients. In this study, we have investigated the levels of bile acid and lysolecithin concentration in gastric juice for the evaluation of some influences of gastroduodena1 reflux on several gastroduodenal diseases. The results were as follows: 1) Bile acid concentration of gastric juice was 46.5±31.0 μmol/l in 13 normal controls, 202.2±109,2 μmol/l in 20 cases of duodenal ulcer, 329.1±101.5 μmol/1 in 28 cases of gastric ulcer 241.8±147.7 μmon/1 in 14 cases of stomach cancer and 352.1±88.7 μmol/1 in 18 cases of non-ulcer dyspepsia. 2) Lysolecithin concentration in gastric juice was 81.0±22.9 μmol/1 in 10 normal controls, 114.3±40.1 μmol/ l in 12 cases of duodenal ulcer, 170.4±43.9 μmol/1 in 10 cases of gastric ulcer, 230.3±172.0 μmol/1 in 6 cases of stomach cancer and 238.9±187.6 μmol/l in 7 cases of non-ulcer dyspepsia. 3) Average bile acid concentration in gastric juice showed a significant increase in each disease group and it was more prominent in gastric diseases including non-ulcer dyspepsia and gastric ulcer than in other groups. 4) Lysolecithin concentration in gastric juice also showed a significant increase in each disease group and it was more prominent in gastric ulcer than in duodenal ulcer. Lysolecithin concentration in the non-ulcer dyspepsia and stomach cancer groups showed a more prominent increase than the control group and duodenal ulcer group but we could not apprehend the clinical significance because the number of cases was negligible. 5) There was no specific correlation between bile acid and lysolecithin concentration of gastric juice in 20 cases of gastric and duodenal ulcers, From our findings, the constant increase of bile acid or lysolecithin concentration in gastric juice might be one of the etiologic factors in development of gastroduodenal diseases, particularly in gastric diseases. However, further study about this problem is thought to be needed.
간 질환들에 있어서 HBs 항원 및 HBs 항체 공존예에 관한 관찰
정정명(Jung Myung Chung),최하진(Ha Jin Choi),박경태(Kyung Tae Park),이시억(Si Eok Lee),진지천(Gi Chun Chin),강기상(Ki Sang Kang),설상영(Sang Yung Seol) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1
N/A A clinica] analysis was made, by enzyme immunoassay, of 64 cases of coexistence of HBs antigen and HBs anti-body in the same serum with the subtype in 12 cases of them being observed. The results were as follows: 1) The overall incidence of coexistence in one period was 1.9% (64/3,395). 2) The highest occurrence rate of coexistence was found in age group of 5th decade: 14 cases (21.9%); in age group of 6th decade: 17 cases (26.6%); and the ratio of male to female was 2.4:l. 3) The diagnostic distributions were 18 cases of liver cirrhosis, 12 cases of hepatoma, 6 cases of chronic active hepatitis, 6 cases of acute viral hepatitis, 7 cases of healthy carrier, and 15 cases were suspected to be chronic hepatitis not confirmed by liver biopsy. 4) In 64 cases of coexistence we studied Hbe antigen and Hbe anti-body in 32 cases. In this study Hbe antigen positive and Hbe antibody negative was found in 18 cases (56.3%); Hbe antigen negative and Hbe antibody positive in 11 cases (34.4%); both Hbe antigen and Hbe antibody vere positive in 1 case (3.1%) and negative in 2 cases (6.2%). 5) The results of subtype were as follows: in 12 cases of HBs antigen positive only, 8 cases were of ay type and the other 4 cases of ay/ad complex type. And in 12 cases of HBs antibody positive onlv, 5 cases v:ere found to be of anti-y type. 5 cases of anti-d type, 1 case of anti-a type and 1 case of anti-y/anti-d complex type. And in 12 cases of HBs antigen and HBs antibody coexistence, ay type antigen were found in 8 cases, and antibody types of these antigen were 8 cases of anti-y type, and 1 case of anti-y/anti-d complex type. In conclusion, although the results of these studies are those of the screening test and have geographic limitation. The coexistance of HBsAg and anti-HBs is considered mostly as a form of seroconversion and rarely as a result of the superinfection with another subtype.
위장관 ( 胃腸管 ) : Campylobacter Pylori와 Carcinogen의 투여에 의한 Mouse의 위점막 변화
정정명(Jung Myung Chung),최하진(Ha Jin Choi),김동수(Dong Soo Kim),설상영(Sang Young Seol),서정철(Jeong Cheol Seo),채창식(Chang Sik Chai) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
N/A Although it has long been assumed tht the infection of pathogenic bacteria within stomach may cause various kinds of gastric diseases, little interest has been really taken because of a previous inability to isolate the organism. However, after a campylobacter-like organism was first isolated in 1983 and is named campylobacter pylori, the association between the infection of campylobacter pylori and the various kinds of gastritis was investigated at a lot of clinics. It seems to be that campylobacter pylori played a important role in the etiology of chronic gastritis or peptic ulcer diseases. But there is limited evidence to suggest such a role. In order to find out how campylobacter pylori affects gastric mucosa, we made an oral administration of campylobacter pylori only, MNNG only, and both of campylobacter pylori and MNNG at the same time to the experimental mice and observed the changes to gastric mucosa in each mice group at periods. The following results were obtained 1) The change of gastric mucosa of the mice that had the administration of only campylobacter pylori: In the three-month group, all the five mice showed inflammatory change in antrum of the stomach but only one mouse showed inflammatory change in body of the stomach and in the six-month group, all the five mice showed inflammatory change in antrum and three of them showed inflammatory change in body of the stomach. 2) The change of gastric mucosa of the mice that had the administration of only MNNG: In the six-month group, two of five mice showed gracie A mucosal abnormality and in the nine-month group, four of seven mice showed grade A and three of seven mice showed grade B abnormality. 3) The change of gastric mucosa of the mice that had the administration of both campylobacter pylori and MNNG at the same time: In the six-month group, two of four mice showed grade A mucosal abnormality and in the nine-month group, two of six mice showed grade B and four of six mice showed grade C mucosal abnormality. But in none of them occurred cancer. From these results, it could be suggested that the campylobacter pylori causes the mucosal changes in the stomach antrum and that, in the longterm infection, this inflammation could progress to the body of the stomach. And also, in the administration of both of campylobacter pylori and carcinogen at the same time, there is high possibility of promoting the development of stomach cancer. Of course, this subject needs a lot of further researches hereafter.
정정명(Jung Myung Chung),정해철(Hae Chul Chng),설상영(Sang Yeong Seol),정승진(Seung Jin Jeong),최석렬(Seok Reyol Choi),최하진(Ha Chin Choe) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A Although several classifications of esophageal varices are reported at present monent, none of them seems to be perfect in terms of clinical applicability. Some are too simple to cover the whole features of varices, or too much complicated to apply practically to clinical practices. Recent remarkable advances of endoscopy has let more precise serial observations and prognostic evaluation of varices be possible without great difficulties. Having observed 373 cases of esophageal varices from Jan. 1981 to June. 1984 at Paik Hospital, In-Je Medical College, we have tried a new classification of esophageal varices, according to not only their shape, size, numbers, colors and locations, but having particular consideration on their bleeding episodes. Endoscopic grades of esophageal varices are classified into following 4 grades, Grade I: One or two tiny tortuous, blue colored varices, less than 2 mm in diameter, being localized in lower esophagus. Grade II: Bead-like tortuosity, blue colored varices, mostly 2-4 mm in diameter being localized in lower esophagus. Grade III: Varices on the top of the varices, red colored, mostly more than 4 mm in diameter with spreading up to mid esophagus. Grade IV: Grade III varices with spreading through the entire esophagus and or down to the fundus of stomach. Bleeding tendency was most frequently observed in Grade IV varices.
한국인 B형 간염 바이러스 관련 간질환에서 HBV C 및 S 유전자 영역 돌연변이의 면역학적 중요성
정정명 ( Jung Myung Chung ),조환진 ( Hwan Jin Cho ),이연재 ( Yeon Jae Lee ),장윤식 ( Yeun Sik Jang ),박은택 ( Eun Taek Park ),최봉기 ( Bong Ki Choi ),모혜경 ( Hye Kyoung Mo ),박영홍 ( Yeong Hong Park ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 본 연구의 목적은 HBV DNA의 C와 S 유전자 영역에서 돌연변이의 빈도를 관찰하고 면역 상태와 C와 S 유전자 영역의 돌연변이 사이에 상관관계를 알아보고자 한다. <방법> HBV 관련 간질환 소아와 성인 34명으로부터 추출한 혈청이나 생검 간조직으로부터 DNA을 추출하였다. 추출한 DNA로부터 HBV의 C와 S 유전자 영역을 증폭하고 클로닝하여 염기서열을 분석하였다. <결과> 34례의 adr type의 분석 결과 32례(94.1%)에서 co