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신생흰쥐 척수후근신경절 세포에서 전압의존성 $K^+$ 전류의 동정
김지목,정승준,김상정,김전,Kim, Ji-Mok,Jung, Sung-Jun,Kim, Sang-Jeong,Kim, Jun 대한약리학회 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.6
Dorsal root ganglion (DRG) is composed of neuronal cell bodies of primary afferents with diverse functions. Various types of ion channels present on DRG neurons may reflect those functions. In the present study, voltage-gated potassium currents in DRG neurons of neonatal rats were characterized by whole-cell voltage clamp method. Two types of delayed rectifier and three types of transient potassium currents were identified according to their electrophysiological properties. The delayed rectifier currents were named $I_{Ke}$ (early inactivating) and $I_{K1}$ (late inactivating). Steady state inactivation of $I_{Ke}$ began from -100 mV lasting until -20 mV. $I_{K1}$ could be distinguished from $I_{Ke}$ by its inactivation voltage range, from -70 mV to +10 mV. Three transient currents were named $I_{Af}$ (fast inactivation), $I_{Ai}$ (intermediate inactivation kinetics), and $I_{As}$ (slow inactivation). $I_{Af}$ showed fast inactivation with time constant of $10.6{\pm}2.0$ msec, $I_{Ai}$ of $36.9{\pm}13.9$ msec, and $I_{As}$ of $60.6{\pm}2.9$ msec at +30 mV, respectively. They also had distinct steady state inactivation range of each. Each cell expressed diverse combination of potassium currents. The cells most frequently observed were those which expressed both $I_{K1}$ and $I_{Af}$, and they had large diameters. The cells expressing $I_{Ke}$ and expressing $I_{Ke}$, $I_{Ai}$, and $I_{As}$ usually had small diameters. Judging from cell diameter, capsaicin sensitivity or action potential duration, candidates for nociceptor were the cells expressing $I_{Ke}$, expressing $I_{Ke}$ and $I_{Ai}$, and expressing $I_{Ke}$ and $I_{As}$. The types and distribution of potassium currents in neonatal rat DRG were similar to those of adult rat DRG (Gold et al, 1996b).
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이정훈 ( Jung Hoon Lee ),홍승표 ( Seung Pyo Hong ),고준권 ( Jun Kwon Ko ),이은영 ( Eun Young Lee ),이강록 ( Kang Lok Lee ),정승준 ( Sung Jun Chung ),구건우 ( Gun Woo Koo ),방소영 ( So Young Bang ),이혜순 ( Hye Soon Lee ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.4
Pachydermoperiostosis (PDP) is a primary hypertrophic osteoarthropathy characterized by digital clubbing, pachydermia, and periostosis, which is inherited as an autosomal dominant or recessive trait. We report on a patient suffering from bilateral knee arthritis for 6 years who was newly diagnosed as PDP. PDP was confirmed by bilateral digital clubbing, hyperhidrosis, and cutis verticis gyrata, findings of pachydermatosis on the forehead and scalp, X-ray findings of proliferative periostitis. This case indicates that PDP is one of several possible rare diseases that should be considered in patients with undifferentiated arthritis. (J Rheum Dis 2015;22:256-259)
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국내 산양(Naemorhedus caudatus) 암컷의 출산시기 행동 특성에 따른 분석 및 관리 방안
조재운 ( Chea-un Cho ),김규철 ( Kyu-cheol Kim ),김기윤 ( Ki-yoon Kim ),이용학 ( Yong-hak Lee ),손장익 ( Jang-ick Son ),정승준 ( Sung-jun Jung ),송동주 ( Dong-ju Song ),정대호 ( Dae-ho Jung ) 한국환경생태학회 2016 한국환경생태학회지 Vol.30 No.5
국제적 멸종위기종인 산양 암컷(n=6)의 출산시기 행동권 분석을 위해 2007년 3월부터 2014년 5월까지 설악산국립공원, 월악산국립공원 2지역에서 GPS collar 발신기를 이용하여 연구 수행하였다. 분석결과 출산시기에 따라 행동권의 변화를 확인하였다. MCP 95%에서 봄 1.00±1.00㎢ > 가을 0.66±0.30㎢ > 여름 0.61±0.40㎢ > 겨울 0.50±0.10㎢(F=4.240, p<0.05)로 분석되었으며, 월별분석은 5, 6, 7월에 급격이 행동권이 작아지는 특징을 보였으며, 통계적으로 유의적인 차이를 보였다(F=24.261, p<0.01). 이렇듯 행동권의 급격한 변화를 보인개체들은 새끼를 출산한 개체로 확인 되었고, 행동권이 급격히 작아지는 것을 확인 할 수 있었다. 평균 이용고도는 615.77±173.508m이며 출산개체와 비출산 개체 모두 큰 차이는 없었다. 이러한 분석을 통하여 출산 시기 등을 고려한 개체관리 및 복원에 적용할 수 있을 것으로 판단된다. To analyze the behavioral characteristics of Korea endangered species female gorals (n=6) during the period of birth, using GPS collar attached on their necks, we carried out this study in two areas (Seoraksan and Woraksan National park) from March 2007 to May 2014. According to our analysis there was a change in their home range during the period of birth. The home range of females (n=6) in MCP 95% was Spring (1.00±1.00㎢) > Autumn (0.66±0.30㎢) > Summer (0.61±0.40㎢) > Winter (0.50±0.10㎢) (F=4.198, p<0.05). In the monthly analysis, their home ranges were dramatically reduced in May, June and July. It showed a statistically significant difference (F=24.261, p<0.01). These gorals showing a drastic change in home ranges were identified as gorals having offspring individual and their home ranges were decreased. The average altitude was 615.77±173.508m and there was no significant difference in major change between parous and nonparous female gorals. Through this analysis, we expect that it can be applied to the goral management and restoration project considering the time of birth.
ScienceON
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