봄철(4~6월)의 패조류 관리

장정원,Jang, Jeong-Won 선박안전기술공단 1985 漁船 Vol.22 No.-

외래에서 B형간염 치료

장정원 ( Jeong Won Jang ) 대한간학회 2018 간질환 연수강좌 Vol.2018 No.1

중개 연구 제안하기

장정원 ( Jeong Won Jang ) 대한간학회 2022 임상연구방법론워크숍 Vol.2022 No.1

바이러스 간염

장정원 ( Jeong Won Jang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.2

간세포암종 진단 및 예후예측에서의 CTC 및 Exosomal miRNA의 유용성

장정원 ( Jeong Won Jang ) 대한간학회 2021 임상연구방법론워크숍 Vol.2021 No.1

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver and one of the leading causes of cancer-related mortality worldwide. The etiology of HCC IS varied with a range of different presentations and natural histories. Despite the recent advances in treatments, the overall prognosis of HCC still remains unsatisfactory. Especially, patients with advanced-stage HCCs suffer from poor survival rates and this requires the discovery of novel, efficient Diomarkers for early diagnosis and prognosis of HCC, identifying risk factors, distinguishing HCC from non-HCC liver diseases, and assessment of treatment response. Liquid biopsy has emerged as a novel minimally invasive approach to enable early diagnosis and monitoring tumor progression, metastasis, and recurrence of HCC. Next-generation sequencing (NGS) technologies provide accurate and comprehensive gene expression and mutational profiling of liquid biopsies including cell-free circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and genomic components of extracellular vesicles (EVs) including micro-RNAs (miRNAs), long non-coding RNAs (IncRNAs) and circular RNAs(circRNAs). HCC Is a highly heterogeneous malignancy, patients with HCC can display various genomic, epigenomic, and transcriptomic patterns and exhibit varying sensitivity to treatment options. Identification of individual variabilities in genomic signatures in liquid biopsy has the potential to greatly enhance precision oncology capabilities. Herein, the short summary will provide a brief review of commonly used liquid biopsies, such as CTCs and miRNAs, in HCC and discuss the latest progress in their application for advancing HCC personalized medicine.

고주파열치료(Radiofrequency Ablation) 후 발생한 합병증 증례 고주파열치료 시술후 발생한 장폐색증

장정원 ( Jeong Won Jang ),배시현 ( Si Hyun Bae ),최종영 ( Jong Young Choi ),윤승규 ( Seung Kew Yoon ),이영준 ( Young Jun Lee ),변재영 ( Jae Young Byun ) 대한간암학회 2005 대한간암학회지 Vol.5 No.-

현재 사용되고 있는 간세포암 병기의 종류와 문제점

장정원 ( Jeong Won Jang ) 대한간암학회 2008 대한간암학회지 Vol.8 No.-

항만시설사용허가 대리신청인에 대한 사용료 부과의 문제점과 개선방안

장정원(Jang, Jeong-Won),이향숙(Lee, Hyang-Sook) 한국물류학회 2021 물류학회지 Vol.31 No.4

선주나 화주는 항만을 이용하여 선박을 입출항하고, 화물을 옮기는 과정에서 항만시설을 사용하게 되는데 이 경우 항만시설을관리하는 자에게 사용 허가를 받아야 하고, 사용의 대가로 항만시설사용료를 납부하여야 한다. 다만, 항만시설사용 허가 신청을선주나 화주가 직접 수행하지 않고 항만하역사업자나 해운대리점이 대리하는 경우가 있는데, 이 경우 항만시설에 대한 사용허가신청을 한 자와 실제 항만시설을 사용한 자가 다르다는 점에서 신청인과 사용인 중 누가 항만시설사용료 납부의무자인지에 대한다툼이 있어왔다. 이에 대하여 해양수산부는 선주나 화주, 항만하역사업자와 해운대리점 모두 항만시설사용료를 납부할 의무가있다고 인정하고, 실제로 대리인인 항만하역사업자와 해운대리점에게 항만시설사용료를 부과하고 있으나, 우리나라 법원은 1996 년, 2001년의 판결을 통하여 항만시설사용료를 납부할 의무자는 항만시설사용으로 인해 실질적인 편익을 얻는 선주나 화주에 한정되고, 항만하역사업자와 해운대리점은 단순히 허가 신청 절차를 대리하는 자에 불과하므로 허가 신청 절차를 대리하면서 수수료를 얻는 등의 이익을 얻고 있다고 하더라도 항만시설사용료를 납부할 의무는 없다고 판단하였다. 따라서, 본 연구에서는 항만시설사용료 납부의무자에 대한 해양수산부의 태도와 법원의 판결을 소개하고, 항만시설사용료의 납부의무자에 대한 확립된 법리에따라 항만하역사업자와 해운대리점에 대한 부당한 사용료 청구 지양 및 실제 항만시설사용자인 선주나 화주에 대한 사용료 징수를 위한 항만시설사용 허가 신청 방식 변경을 제안하였다. Shipowners and shippers use port facilities in the process of their vessels entering and leaving the port and transporting cargo. For this purpose, a permit to use the port facility must be obtained from the person who manages the port facility, and a usage fee must be paid. However, there are cases where the shipowners or shippers do not directly apply for a permit to use the port facilities but have a port cargo handler or a shipping agency act on their behalf. It has been disputed whether the agent or the user is obliged to pay for the usage fee, given that the person who applied for the port facility use permit is different from the person who actually used the facility. In response, the Ministry of Oceans and Fisheries recognizes that shipowners and shippers, port cargo handlers and shipping agencies are all obligated to pay the port facility usage fees, and indeed imposes the fees on their agents, who are the port cargo handlers and shipping agencies. However, according to the court rulings in 1996 and 2001, the duty to pay the port facility usage fee is limited to the shipowner or shipper who obtains substantial benefits from using the port facility, since the port cargo handlers and the shipping agencies are merely proxy applicants for the permit application process, and it was judged that there is no obligation for port cargo handlers and shipping agencies to pay the fees even if profits in the form of commissions are accrued to them while acting as agencies for the permit application process. Therefore, in this study, the viewpoints of the Ministry of Oceans and Fisheries about those obligated to pay port facility usage fees and the court rulings are reviewed. Given that it is necessary to avoid unreasonable charges for port cargo handlers and shipping agencies in accordance with the established legal principles on payment of port facility usage fees, this study proposes changes in the practice of applying for port facility usage permit to collect usage fees from the shipowners or shippers who are the de facto port facility users.

STEAM(융합인재)교육을 기반으로 한 유아미술교육이 유아의 미적반응과 창의적 문제해결력에 미치는 효과

장정원 ( Jang Jeong-won ),이순복 ( Lee Soon-bok ) 한국아동교육학회 2020 아동교육 Vol.29 No.3

본 연구는 STEAM(융합인재)교육을 기반으로 한 유아미술교육이 미적반응과 창의적 문제해결력에 미치는 효과를 알아보는데 목적이 있다. 연구대상은 P시에 소재하고 있는 Y어린이집 만 5세 2개 학급 40명이었으며, 실험집단과 통제집단으로 나누어 20회기의 교육을 실시하였다. 수집된 자료는 평균과 표준편차를 산출하여 두 집단의 사전검사 점수를 공변인으로 한 공변량분석(ANCOVA)으로 분석되었다. 연구 결과는 첫째, STEAM(융합인재)교육을 기반으로 한 유아미술교육이 미적반응 중 시각적 정보에 기초한 반응에 효과가 있었고, 가정적 반응에는 유의미한 효과가 없는 것으로 나타났다. 둘째, 유아의 창의적 문제해결력에는 전체적으로 효과가 있는 것으로 나타났다. 이러한 결과는 STEAM(융합인재)교육 기반의 미술교육이 유아의 미적반응과 창의적 문제해결력 발달에 효과적인 교육활동으로 유아교육현장에서 적용 가치가 있음을 시사하고 있다. This study investigates the effect of STEAM Education based Art Education on young children’s aesthetic response creative problem solving ability. The subjects, all 5-year-old, were divided into two groups. One group, as a experimental group(n=20), and the second served as a control group(n=20). The collected data were analyzed using ANCOVA. The results were as follows: First, STEAM Education based Art Education were found to make significant differences to response to visual information, but, there wasn`t a significant differences assumptive response of the aesthetic responses of young children. Second, STEAM Education based Art Education were found to make significant differences to the understanding of problems, the generation of ideas, and the plans for action, which are sub-factors of creative problem solving ability. In conclusion, art education in a STEAM program is an effective teaching and learning method for developing children's aesthetic response and creative problem solving ability.

회양목과 갯버들에 대한 꿀벌의 방화활동에 관한 연구

장정원(Jeong-Won Jang),류장발(Jang-Bal Ryu) 한국양봉학회 2014 韓國養蜂學會誌 Vol.29 No.2

Studies on foraging activity of honeybees; Apis mellifera at flowers of Buxus microphylla var. koreana and Salix gracilistyla were investigated in order to evaluate the two species as honey plants from March 10 to 30 in 2003 at the arboretum in Daegu University. Honeybees visited flowers from 11 to 16 o’clock, while the temperature was over 12°C More bees visited Salix gracilistyla than Buxus microphylla var. koreana, which were much smaller than the former. Buxus microphylla var. koreana bloomed from March 10 to 25 and Salix gracilistyla did from March 12 to 30. Though the number of bees visiting these two species were not great, these two species proved as good honey plants at early spring.