http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
금연의 준비단계이전에서 준비단계로, 준비단계에서 준비단계이후로의 이행에 대한 예측변인 : 청소년과 성인 비교
장성옥(Chang Sung Ok),김은주(Kim Eun Ju),서문경애(Seomun Gyeong-Ae),이수정(Lee Su Jeong),차보경(Cha Bo Kyung) 기본간호학회 2006 기본간호학회지 Vol.13 No.1
Purpose: This study was done to identify predictors differentiating the preparation stage, which is the stage that the smoker is ready to quit smoking, between adolescent smokers and adult smokers. Method: A survey was conducted with 376 adolescent smokers in 4 high schools and 451 adult smokers in community settings in South Korea from August 2003 to April 2005. To identify the predictors before and after preparation in stages of change of smoking, logistic regression was done. Results: The predictors for before preparation in stages of change of smoking were process of change for smoking abstinence for adolescent smokers and depression for adult smokers. The predictors for after preparation in stages of change of smoking were self-efficacy for smoking abstinence for adolescent smoker and self-efficacy for smoking abstinence and smoking temptation for adult smokers. Conclusion: For each group, adolescent smokers and adult smokers, specific smoking intervention methods need to be developed based on the different ways individuals make the decision to quit smoking within their contexts.
Symposium 5-4 (SYP 5-4) : Practical things of pigment cell research in the clinical field
장성은 ( Sung Eun Chang ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Melanin is crucial for skin color and protection from ultraviolet (UV) radiation-induced damage. However, over-production and accumulation of melanin due to extreme exposure to UV irradiation or chronic inflammation could lead to various hyperpigmentary skin disorders, such as melasma, freckles, lentigines and post-inflammatory hyperpigmentation (PIH). Particularly, the disease course of melasma is sometimes unpredictable and indicates other subclinical systemic involvement beyond the paracrine action of the skin. Neuroendocrine modulation, alteration of lipid metabolism or inflammatory events may be associated at least with some patients with melasma. We already have known that the key to the point of treatment of melasma is successful long term maintenance of ‘good’ improvement outcome, not the removal of hyperpigmented patches themselves. Therefore, melasma should be handled with approaches toward a medical disease rather than acondition for skin resurfacing indication. Another commonly encountered lesion is lentigo. Childhood onset epidermal melanotic macules, lentigo simplex, early onset solar lentigines, senile lentigines with solar damage, certain type of seborrheic keratosis and benign lichenoid keratosis comprise the list of ‘lentigines’ which might have responded differently to treatments. The role of visible light on hyperpigmentation and the long newer lists of various lasers make the PIH story even more complex in Korean skin with certain detailed skin types.
건선 표피에서의 p53, pRb, p16, p21 및 PCNA에 대한 면역조직화학적 고찰
장성은(Sung Eun Chang),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),최지호(Jeo Ho Choi) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9
N/A Background : Psoriasis is a chronic disorder which is characterized by hyperproliferation and abnormal differentiation of keratinocytes with T-cell infiltration. There is increasing evidence that inactivation of tumor-suppressor genes can promote uncontrolled cell proliferation and tumor formation. The products of p53, Rb, p16, p21 genes are examples of the molecules the cell growth cycle. Objective : In this study, immunhistochemical analysis of cell cycle-related molecules (p53, pRb, p16, p21Wafl, and PCNA) was done to elucidate the roles and interactions of those molecules in the pathogenesis of psoriatic keratinocytes. Materials and methods : Formalin-fixed skin samples composed of 20 chronic plaque type psoriatic, 20 nonlesional and 20 normal epidermis, and 5 squamous cell carcinomas were included in this study. Results : Our results suggest that p53 protein accumulation is an early event in cutaneous SCC, but not in psoriasis. In our study, diffuse expression of p16 with almost negative expression of pRb in psoriatic epidermis suggest that inverse relationship is maintained. Although loss of p16 expression is frequently associated with many kinds of cancers, we speculate there is a possibility that is a strong expression of p16 is related to localized cancer as well as in benign hyperproliferative lesions. In psoriasis, p21 may be overexpressed via a p53-independent pathway. The number of PCNA positive cells was higher in the psoriatic epidermis in contrast to scattered staining in the psoriatic nonlesional and normal epidermis Conclusion : The proliferative status of psoriatic leratinocytes dose not implicate Rb gene and may not implicate the p53 gene significantly. It is associated with the strong expression of PCNA and moderately increased expressions of p16 and p21. (Korean J Dermatol 1999;37(9) : 1286∼1295)
Approach to the patients with hyperpigmentation disorders
장성은 ( Sung Eun Chang ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Hyperpigmentation is skin darkening in usually due to an increased deposition of melanin (hypermelanosis) in the epidermis and/or dermis with or without increased melanocytosis. Less frequently, it may be caused by the deposition in the dermis of endogenous or exogenous pigments, such as hemosiderin, iron, silver and etc. Choices of treatment modalities and timing are dependent on clinical lesional and patient-tailored classification as followings. congenital or acquired skin limited, systemic disorder or syndrome malignant potential or none exposed area or non-exposed area circumscribed or diffuse patterned (linear or reticulate) or non-figure acute or chronic stationary or progressive inflammatory or non-inflammatory symptomatic or non-symptomatic causes(aggravating factors) identified or idiopathic psychosocial burden or negligible economic burden due to treatment costs or negligible Due to the limited efficacy and frequent side effects of the available treatments of skin hyperpigmentation disorders, appropriate counselling prior to treatment and maintenance program of treatments are mandatory in order to attain the final goal, an enhancement of patient’s quality of life for long time.
피부 비만세포증 30 예의 임상 및 병리 조직학적 고찰
장성은(Sung Eun Chang),강숙경(Sook Kyoung Kang),지민선(Min Sun Jee),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.5
N/A Background : Mastoeytosis is characterized by accumulation of mast cells in various organs, most frequently in skin. Cutaneous mastoeytosis is a relatively rare disease in outpatient clinics and the clinicopathological study has not been done yet in Korea. Objective : The ain of this study is to analyse the clinieopathological features of cutaneous mastocytosis. In addition, we examined CDU7 expression in the skin biopsy specimens immunohistochemically Methods : Thirty cases of cutaneous mastocytosis were collected from 1990 to 1999 in Asan Medical Center. Clinical records, photographs. and biopsy slides were reviewed. In each biopsy specimen, CDU7 was stained by immunoperoxidase method. Results : Among 30 cases, 29 cases were childhood type urticaria pigmeniosa(76.7 %) or mastocytoma(20.2%) and only I case occurred after 16 years of age. The incidence showed a peak under 1 year old (70.0%) and mates affected 2.3 times as much as females. The trunk and distal extremities are the most common site of urticaria pigmentosa and mastocytoma respectively. CD117 was strongly positive in all cases of utricaria pigmentosa (both child and adult type) and mastocytoma. Conclusion : Urticaria pigmentosa of infantile onset was the most common, followed by infantile mastocytoma. Systemic reactive manifestations are rate in cutaneous mastocytosis. The strong expression of CD117 was seen regardless of cutancous mastocytoses.