http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
장도협,유수빈,안동준,김세훈,김동하 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Anatase titania (aTiO<sub>2</sub>) coated gold nanoclusters are hard to applied for cancer therapy due to their aggregation issue and morphological disruption of gold during amorphous TiO<sub>2</sub> phase changes. Herein, we share a novel methodology to coat aTiO<sub>2</sub> onto gold nanobipyramids (Au NBP) at low temperature ranges. The resulting well-defined Au NBP/aTiO<sub>2</sub> structures retained their morphology and sharp metal tips responsible for strong electric fields. Preliminary catalytic activity results demonstrated the generation of reactive oxygen species under laser irradiation, sustaining an injection of LSPR-induced hot electrons onto the TiO<sub>2</sub> conduction band, for which the well-preserved sharp gold tip and clear monodispersity of our materials played a critical role. Au NBP/aTiO<sub>2</sub> uncovered superior results for cancer therapy ascribed to their high uptake rate by human glioblastoma, biocompatibility assessed under dark conditions, and, most importantly, photothermal and photodynamic dual therapeutic effect.
유수빈,장도협,이혁진,김동하,김세훈 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Upconversion nanoparticles (UCNP) represent promising agents in biomedical applications due to their photostability, tunable emission band, and low cytotoxicity. However, the intrinsically low quantum efficiency have restricted their viable applications. The integration of localized surface plasmon resonance (LSPR) has been considered as a promising way to overcome this limitation. Herein, we prepared the Au NR@TiO<sub>2</sub> decorated with UCNP to utilize the phototherapy by plasmon-enhanced UCL. TiO<sub>2</sub> shell not only used for spacer between plasmonic nanostructurs and UCNP which could inhibit the quenching effect , but also directly used as inorganic photosensitizer to overcome the limitation of conventional organic photosensitizer. In presence of UCNP, the emitted UV light was proposed to excite the TiO<sub>2</sub> semiconductor and play a key role in the generation of cytotoxic reactive oxygen species. Furthermore, LSPR-induced photo-thermal effect was utilized for achieving the photothermal therapy.
유수빈,장도협,Swarup Kumar Maji,정경화,이준상,Filipe Marques Mota,Jianfang Wang,김세훈,김동하 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-
In the exploitation of nanozymes possessing intrinsic enzyme-like activities for cancer therapy, minorfocus has been devoted to plasmonic nanostructures with localized surface plasmon resonance (LSPR)-driven properties. Here, we report the application of unique peroxidase-mimicking plasmonic photonanozymescoupling tumor-microenvironment-responsive reactive oxygen species generation with photothermaleffect for effective combinatorial therapy. The well-defined anisotropic photo-nanozyme issynthesized by selectively depositing Pd nanoparticles on the tips of gold nanobypyramids. Intrinsicperoxidase-like properties with 1.5-fold-activity enhancement under photoexcitation are ascribed to aPd-induced hot electrons/holes separation with efficient H2O2 decomposition. The LSPR-induced photocatalytic/photothermal combinatorial effects are remarkably enhanced upon H2O2 addition, criticallysuppressing the cell survival rate under near-infrared light. An effective decomposition of cellsignalingH2O2 additionally reveals prominent expression hindrance of vascular endothelial growth factorand hypoxia-inducible factor 1a. Our seminal findings uncover an interrelation between LSPR-inducedphenomena and biomimetic fingerprints, valuable to overcome the shortcomings of conventional photodynamictherapy.
유수빈,장도협,김동하,김세훈 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Anisotropic gold nanoparticles possessing localized surface plasmon resonance (LSPR) have shown emerging interest to enhance the catalytic activities. LSPR can offer local electric field enhancement and induce the generation of hot carriers, which subsequently lead to enhanced intrinsic enzyme-like activity for the generation of ROS. Here, we synthesized uniform gold nanostructures, with selective deposition of transition metal at the end. The rational design herein proposed allowed a facile collection of induced hot carriers at the incorporated metal centers, facilitating the generation of hydroxyl radicals. LSPR-enhanced peroxidase-like activity was further confirmed by hydrogen peroxide and TMB. Under NIR light irradiation, in vitro enzymetic therapeutic effect could be significantly enhanced. Our work highlights the ability of this novel and highly efficient hybrid nanocomposite as a NIR-responsive tumor therapy.
Plasmonic Nanostructure based Light-enhanced Bioorthogonal Catalyst for Cancer Treatment
유수빈,장도협,김동하,김세훈 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Bioorthogonal catalyst could provied a platform for the changing of substrates to activated specieces that mimics the enzymes in biological reactions. Palladium catalysts are highly efficient catalyst for bioorthogonal reaction of prodrugs and pro-fluorophores, however, the intrinsically insufficient catalytic activities have resticted their biological in vivo appication. Herein, we developed the palladium catalysts hybrid with plasmonic nanostructure to enhance the bioorthogonal catalytic activities by introducing the light. The light can modulate the catalytic performance of these bioorthogonal nanocatalysts in terms of LSPR induced hot carrier generation and local field enhancement, which in return, would enhance the bioorthogonal catalytic activities and generate more activated drugs at the given condition. In addition, photothermal effect will be incorporated to achieve synergistic photothermal and chemotherapy.
유수빈,김동하,장도협,김세훈,이혁진 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Lanthanide-doped upconversion nanoparticles (UCNP), with the unique ability to convert low-energy NIR radiation to high energy UV-vis light, represent promising agents.However, the intrinsically low quantum efficiency due to the presence of surface defects and small absorption cross-section have restricted their viable applications. The integration of localized surface plasmon resonance (LSPR) has been considered as a promising way to overcome this limitation.In this work, titanium-coated gold nanorods (Au NR@TiO<sub>2</sub>) were decorated with UCNP. This core@shell nanostructures revealed enhanced UCNP-derived UV emission due to the plasmonic properties of Au NR. In presence of UCNP, the emitted UV light was proposed to excite the TiO<sub>2</sub> semiconductor and play a key role in the generation of cytotoxic singlet oxygen or reactive oxygen species. Hybrid nanostructures herein introduced are suggested to be a valuable addition in deep-range noninvasive cancer phototherapy studies.