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기관내 삽관에 의한 혈압과 심박수 변화에 대한 Urapidil 의 효과
양희성,신창규,김영추,전석봉,임준구 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.31 No.4
Background: Urapidil is a new antihypertensive agent known to diminish total peripheral vascular resistance by postsynaptic a 1-adrenergic blockade and central sympatholytic activity. The purpose of this study was to determine its effectiveness and safety in preventing hemodynamic responses to endotracheal intubation under general anesthesia. Methods: Thirty normotensive, ASA physical status I patients for elective surgery were selected randomly. They were divided into three groups(Group 1: control group with saline, Group 2: urapidil 0.4 mg/kg, Group 3: urapidil 0.5 mg/kg, n=10 in each group). The drugs were injected 3 minutes before induction with thiopental sodium(4 mg/kg) and succinylcholine(1 mg/kg). Endotracheal intubation was performed 5 minutes after the drugs injection. After endotracheal intubation, vecuronium 0.1 mg/kg was injected and 50% nitrous oxide in oxygen and 2Vo1% enflurane were inhaled. We measured the blood pressure and the heart rate with noninvasive method at one minute interval for 5 minutes. Results: In group 3, no significant increase in systolic blood pressure after endotracheal intubation was noted(p$lt;0.05). Urapidil groups showed increase in heart rate at 1, 2 minutes after urapidil injection(p$lt;0.05) and did not blunt increase in heart rate after endotracheal intubation. The side effects of urapidil(hypotension, dizziness, headache and chest tightness) occured in a patient of group 3. Conclusions: We found that the blood pressure response was effectively controlled, but the change in heart rate was not controlled by urapidil 0.5 mg/kg injection before induction.