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보크트-고야나기-하라다 증후군 환자 1예에서 치유 경과에 따른 다국소망막전위도 변화
임상현,박수은,박태관,온영훈,Sang Hyun Lim,Su-Eun Park,Tae Kwann Park,Young Hoon Ohn 대한안과학회 2006 대한안과학회지 Vol.47 No.3
Purpose: To assess the changes of retinal function together with recovery progress in a patient with Vogt-Koyanaki-Harada syndrome using a multifocal electroretinogram (mfERG). Methods: The retinal changes of a 32-year-old woman diagnosed with Vogt-Koyanaki-Harada syndrome have been investigated and compared for different times such as before treatment and 3 and 6 months after treatment using a fluorescein angiogram, electroretinogram (ERG) and mfERG. Results: As time passed, the patient`s visual acuity was recovered, the serous retinal detachment in the posterior pole was restored, and the phenomenon of late subretinal leakage disappeared on fluorescein angiogram, while aggregation and atrophy of the retinal pigment epithelium were detected. The early-stage responses of the retina decreased on ERG; however, it has gradually recovered and was determined to be normal after 6 months. Responses measured on the mfERG have increased during the 6 months after surgery compared to the pre-treatment, but there was still a partial lack of response. Conclusions: In this case, the abnormal condition of retinal function existed continuously on the mfERG, even when the serous retinal detachment in the posterior pole was recovered. In this regard, a long-term systematic investigation and subsequent mfERG treatment have been thought to be necessary for patients with this disease.
임상현,조문식,김준순.Sang-Hyun Lim. M.D.. Moon-Sik. Cho. M.D.. Joon-Soon. Kim. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.9
Purpose: To evaluate stability and effects of photochromic lenses in light-sensitive patients. Methods: Analyzing 65 patients, this research employed a standardized survey, fundus examination, and slit-lamp biomicroscopy to evaluate the changes in photophobia, tears, asthenopia, and the deterioration of outdoor visual acuity after wearing photochromic lenses for one month. Measurement of visual acuity was performed outdoors at noon on a bright day using Dr. Hahn’s standard test chart for 3 m. Results: Photochromic lenses, considerably decreased photophobia, tears, and asthenopia. The “normal” visual acuity of 38 patients was established without photochromic lenses. Re-examination after the lenses had been worn for a specified period of time showed that 29 subjects could discern at least one line higher than their “normal” acuity. Conclusions: Photochromic lenses reduced photophobia and the disabling effect of bright light such that comfort was increased. Not only did the lenses improve vision, they also enhanced the overall quality of vision.
임상현(Sang-Hyun Lim),김희연(Hee-Yeon Kim),박민희(Min Hee Park),박유화(Yu Hwa Park),함헌주(Hun Ju Ham),이기연(Ki Yun Lee),김경희(Kyung-Hee Kim),박동식(Dong Sik Park),김성문(Songmun Kim) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.12
돌단풍 잎의 항산화, 항염, 항당뇨, 항비만 활성을 탐색하고자 강원도 양구에서 자생하고 있는 돌단풍의 잎을 채집하여 에탄올과 증류수로 각각 추출하였다. 항산화 활성은 DPPH 라디칼 소거반응, 총 폴리페놀 함량 및 총 플라보노이드 함량을 측정하여 검정하였다. 돌단풍 잎의 에탄올과 물 추출물의 DPPH 라디칼 소거능 IC50값은 각각 549.86과 62.14 ㎍/mL이었고, 총 폴리페놀 함량은 에탄올 추출물이 307.63 ㎎/g으로 물 추출물의 총 폴리페놀 함량인 86.96 ㎎/g보다 높게 나타났으나 총 플라보노이드 함량은 에탄올과 물 추출물 각각 118.98과 110.16 ㎎/g으로 비슷한 함량을 나타냈다. 항염 활성은 RAW264.7 세포에 LPS와 돌단풍 잎 추출물을 동시에 10 ㎎/mL 처리하여 NO 생성량을 측정하였으나 효과는 없었다. 항당뇨 활성은 α-glucosidase와 α-amylase 저해활성을 측정하였으며, 돌단풍 에탄올과 물 추출물의 α-glucosidase IC50값은 각각 5.62와 425.63 ㎍/mL이었고, α-amylase IC50값은 각각 4,623.87과 10,000 ㎍/mL 이상으로 돌단풍 에탄올 추출물의 항당뇨 활성은 매우 뛰어났다. 항비만 활성 탐색은 pancreatic lipase의 활성저해를 측정하였으며, 그 결과 돌단풍 잎의 에탄올과 물 추출물의 IC50값은 모두 10,000 ㎍/mL 이상으로 항비만 활성은 없는 것으로 나타났다. 이러한 결과 돌단풍 잎 추출물의 항산화, 항당뇨의 기능성활용 가공식품 및 건강기능식품으로의 개발이 기대된다. In this study, the bioactivities of ethanol (EEAR) and water extract (WEAR) from the leaf of Aceriphyllum rossii were investigated. In the anti-oxidative activity, IC50 of DPPH radical scavenging activity was respectively 549.86 and 62.14 ㎍/mL by EEAR and WEAR. Anti-inflammatory activity of EEAR and WEAR has been evaluated on inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) release by the macrophage RAW 264.7 cells. EEAR and WEAR inhibited inflammatory by 5.58 and 16.85% in 10 ㎎/mL, respectively. In the anti-diabetic activity, IC50 of α-glucosidase inhibitory activity was 5.62 and 425.63 μg/mL by EEAR and WEAR. IC50 of α-amylase inhibitory activity of EEAR and WEAR was 4,623.87 and over 10,000 ㎍/mL, respectively. In the anti-obesity, all lipase inhibitory activity (IC50) of EEAR and WEAR was up 10,000 ㎍/mL. Finally, EEAR and WEAR exhibited anti-oxidative and anti-diabetic activity. It suggests that Aceriphyllum rossii could be potentially used as a resource of bioactive materials for health functional foods.
EDR 기록정보를 활용한 다중 및 연쇄 추돌 사고 분석
임상현(Sanghyeon Lim),박종찬(Jongchan Park),김종혁(Jonghyuk Kim),오원택(Wontaek Oh),최지훈(Jihun Choi),박종진(Jongjin Park) 한국자동차공학회 2019 한국 자동차공학회논문집 Vol.27 No.2
Careless driving on the highway, where vehicles are traveling in high speeds, can lead to multiple car, rear-end, or chain reaction collisions. When these accidents occur, the sequence of collision, the bullet vehicle’s speed, and whether or not the braking function worked become major issues. In this study, a multiple car, rear-end, and chain reaction collision test was performed with vehicles that were equipped with EDR function. Based on EDR data, the sequence of collision and the bullet vehicle’s speed were analyzed. To supplement the limitation of the analytical method in which EDR data were used, theoretical rigid body dynamics and collision reconstruction simulation through PC-Crash was also conducted. Through such a series of processes, this article proposed a reliable method of analysis for multiple car, rear-end, and chain reaction collisions.
마디모를 이용한 차 대 보행자 사고 재구성에 관한 연구
임상현(Sanghyeon Lim),김종혁(Jonghyuk Kim),오원택(Wontaek Oh),최지훈(Jihun Choi),박종찬(Jongchan Park) 한국자동차공학회 2019 한국 자동차공학회논문집 Vol.27 No.7
In the event of a pedestrian accident, the pedestrian is at high risk of severe injury that may result in death due to lack of safety equipment. In a pedestrian accident, both the impact position of the pedestrian and vehicle velocity just before the impact are important factors that need to be calculated. The accident is reliably recreated through the MADYMO simulation by using the speed before the impact, the injured area of the pedestrian, and the damaged state of the vehicle. However, the reliability and utilization of MADYMO are not yet confirmed. Therefore, this paper recreated the accident by using MADYMO in order to demonstrate the reliability and utilization of the simulation results under the situation where the accident video exists. The initial impact position and dummy posture were set by using accident videos and photos of the damaged vehicle. Furthermore, vehicle speed was calculated by investigating the accident video and considering the thrown distance of the pedestrian. Through the MADYMO simulation, the thrown distance of the human dummy model was compared with a real accident. In addition, the difference between the pedestrian behavior and dummy model’s behavior was compared. This study indicates that the MADYMO is reliable in using simulation results based on thrown distance, physical evidence, etc.