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세포 기반 고집적 스크리닝 시스템용 비접촉식 고정밀 마이크로 디스팬서 제작
조성진(Seong J. Cho),김인태(Intae Kim),임근배(Geunbae Lim) 대한기계학회 2016 大韓機械學會論文集A Vol.40 No.6
최근 고령화 사회에 진입과 소득수준이 향상됨에 따라 의료 수요가 빠르게 증가되고 있다. 이중 신약 개발은 의료분야의 핵심 분야 중 하나로 전 세계적으로 많은 투자가 연구가 이루어지고 있다. 신약 개발의 중요한 과제 중 하나는 다양한 후보를 빠르고 정확하게 발굴하는 자동화 시스템을 개발하는 것이다. 고속으로 후보물질을 발굴하는 기술 중 대표적 기술이 세포 기반 고집적 스크리닝 시스템(High Contents Screening, 이하 HCS) 기술이다. 이 HCS 시스템에서 다양한 물질을 한꺼번에 스크리닝하기 위해서는 다기능 고정밀 디스팬서 제작이 필수적이다. 본 연구에서는 기존의 HCS 디스팬서 시스템이 가지고 있는 단점을 보완하기 위해 에어건과 압력 구동식 펌프를 이용한 새로운 컨셉의 비접촉식 디스팬서를 개발하고 그 가능성을 확인한다. Nowadays medical treatment service increase due to ageing population and improving the quality of life. Accordingly it is predicted that drug discovery market will expansion continuously. Therefore it is necessary that profit creation by drug discovery on the global market is important. HCS(High Contents Screening) has been emerging as a potential method to solve problems of the present drug discovery. This research is about liquid dispenser for HCS. The purpose of this research is to manufacture high performance liquid dispenser for HCS. The dispenser is designed to control 5 liquids separately. The liquid contact parts are designed disposably, biocompatibly and chemically inertly. Air curtain is equipped at the side of tip to dispense very small liquid volume and to prevent hanging drop on tip. Valving is performed by just controlling the pressure of the pressure driven pump without valve.
Poly-dimethylsiloxane (PDMS) 기판 위에 형성된 나노구조를 이용한 시각 인장센서의 개발
김건휘 ( Geon Hwee Kim ),우현수 ( Hyeonsu Woo ),임근배 ( Geunbae Lim ),안태창 ( Taechang An ) 한국센서학회 2018 센서학회지 Vol.27 No.6
Structural color has many advantages over pigment based color. In recent years, researches are being conducted to apply these advantages to applications such as wearable devices. In this study, strain sensor, a kind of wearable device, was developed using structural color. The use of structural color has the advantage of not using energy and complex measuring equipment to measure strain rate. Wrinkle structure was fabricated on the surface of Poly-dimethylsiloxane (PDMS) and used it as a sensor which color changes according to the applied strain. In addition, a transmittance-changing sensor was developed and fabricated by synthesizing additional glass nanoparticles. Furthermore, a strain sensor was developed that is largely transparent at the target strain and opaque otherwise.
Simple fabrication method of the unique micro/nano structures using synchrotron X-ray
Kanghyun Kim(김강현),Kyungjin Park(박경진),Geunbae Lim(임근배),Jong Hyun Kim(김종현) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12
Micro- and nanofluidic devices are being used increasingly in biological, chemical, and medical applications, and many fabrication methods have been proposed. Using the fabricated nanochannels, the generation of ion concentration polarization, a novel transport phenomenon in nanofluidics, was investigated. Our novel fabrication method should be a useful tool for various nanofluidic applications due to its various advantages, including simple fabrication process, controllability, and duplicability. Conventional micro fabrication techniques have been improved to overcome their limitations by developing various methods with a three-dimensional structure. Three dimensional structure or various patterns in shape have been realized, but the process is slightly complicated and the efficiency is low. Nowadays, more efficient and simple fabrication methods are required for the application of various micro-structure based components/devices and systems. In this study, we developed novel fabrication technique to fabricate various tilted micro-structures with a different angle on single substrate using a synchrotron X-ray lithography. Here, we have shown the unique fabrication technique which is based on synchrotron x-ray irradiation and curved/flexible x-ray mask/substrate. Tilted microstructure can have various angles and directions in single substrate.