급성 골수성 백혈병 환자에서 발생한 부종양성 지방층염

김대훈 ( Dae Hun Kim ),김수연 ( Soo Yeon Kim ),임명 ( Myung Im ),이영 ( Young Lee ),조철오 ( Cheol O Jeo ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.11

Panniculitis generally indicates a group of diseases whose hallmark is fibrous thickening and chronic inflammation of subcutaneous fat. Various factors seem to induce a similar pathological histology, and morphological differences can be found among the patients diagnosed with the same disease. Paraneoplastic causes account for 3∼10% of the cases of panniculitis. The commonest causes of cancer associated panniculitis are hematological malignancies and mostly lymphomas. In this case, we confirmed acute myeloid leukemia by a blood test and bone marrow examination, and with considering the clinical aspects and pathological findings of the skin lesion, and we finally diagnosed the patient as having panniculitis, which seems to be related with acute myeloid leukemia. The obvious clinical symptoms or pathophysiological features of this rare type of panniculitis are not yet fully known, and so making the differential diagnosis is needed to distinguish this malady from erythema nodosum, erythema induratum and various connective tissue disorders with accompanying erythematous subcutaneous nodules. We diagnosed this very rare and interesting case of paraneoplastic panniculitis that seemed to be generated from acute myeloid leukemia. We report here on this case and we review the relevant literature. (Korean J Dermatol 2010;48(11):1016∼1019)

피지선 모반과 동반된 이차 종양

노윤우 ( No Yun U ),이증훈 ( Lee Jeung Hun ),박장규 ( Park Jang Gyu ),김유찬 ( Kim Yu Chan ),박향준 ( Park Hyang Jun ),신용우 ( Sin Yong U ),윤태영 ( Yun Tae Yeong ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.10

N/A Background : Frequent association of nevus sebaceus with other skin appendage tumors and with apocrine glands suggests that the nevus sebaceus may be derived from the primary epithelial germ. Syringocystadenoma papilliferum was found most frequently in the nevus sebaceus. A number of cases have been reported, but extensive studies on the secondary tumors of nevus sebaceus are rare in Korea. Objectives : The purpose of this study was to investigate characteristic clinical features in Korean patients with the secondary tumors of nevus sebaceus. Materials & Methods : Enrolled were total 136 patients confirmed as nevus sebceus at the Chungnam National University Hospital, the Dankook University Hospital, and the Chungbuk National University Hospital from March 1993 to February 2003 for this study. And we reviewed the Korean Journal of Dermatology and the Annals of Dermatology for nevus sebaceus with secondary tumors. Result : The results were as follows : 1. Total 45 cases were included from 23 males and 22 females. The male/female ratio was similar. Trichoblastoma(86% in female) and basal cell carcinoma(67% in female) were more frequent in female than in male. 2. Mean age was 38.7 years(range 1.5 years to 71 years). all malignant tumors except basal cell carcinoma developed beyond 40 years of age. 3. In the malignant tumors, 19(95%) or 20 cases developed in the scalp. However, in the benign tumors, 44(86.3%) of 51 cases developed in the scalp and 7(13.7%) of 51 cases in the face. 4. Tumors of one type developed in 29 cases and tumors of more than two types developed in 16 cases. 5. The total seventy eight tumors were composed of 23 malignant tumors and 55 benign tumors. Basal cell carcinoma and syringocystadenoma papilliferum were the most common tumor in each group respectively. Although trichoblastoma was not counted as the most common tumor, we suggest that it might be the most frequent tumor in secondary tumors associated with nevus sebaceus because differential diagnosis between trichoblastoma and basal cell carcinoma was so difficult that many cases of trichoblastoma were misdiagnosed as basal cell carcinoma.(Korean J Dermaton 2003;41(10) : 1338~1346)

Branchio-Oto-Renal 증후군

황철 ( Chul Hwang ),김대훈 ( Dae Hun Kim ),백승주 ( Seung Ju Baek ),이영 ( Young Lee ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.9

Branchio-oto-renal (BOR) syndrome is a rare congenital anomaly that is characterized by preauricular pits, branchial fistula and hearing impairment and it is often combined with renal anomalies. BOR syndrome is inherited in an autosomal dominant mode and the mutations of two genes, EYA1 and SIX1, have been identified. We experienced a case of a 14-year-old female who complained of bilateral neck openings and hearing loss that were found at birth the girl`s family had a familial tendency for these features. A skin biopsy from the cervical lesion showed the characteristic features of branchial fistula. We report here on a case of BOR syndrome and we review the relevant literature. (Korean J Dermatol 2009;47(9):1039∼1042)

피부 기관 배양에서 칼슘이 표피에 미치는 효과

최대경 ( Dae Kyoung Choi ),이경문 ( Kyung Moon Lee ),김대훈 ( Dae Hun Kim ),이영 ( Young Lee ),손경철 ( Kyung Cheol Sohn ),김창덕 ( Chang Deok Kim ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.5

Background: Calcium plays a role in the proliferation and differentiation of keratinocytes. In a normal situation, the calcium concentration forms a gradient across the epidermal layers. Calcium is sparse in the basal layer and spinous layer. Skin organ culture is a useful model for conducting research on various aspects of skin biology. Skin organ culture systems are used for defining factors that affect homeostasis when elucidating the modulatory effects of biologic response modifiers, drugs and physical agents on the skin and also when studying complex aspects of cutaneous biology in normal and diseased skin. Objective: In this study, we investigated the effects of extracellular calcium on the epidermis in a skin organ culture. Methods: We compared the skin organ culture patterns under various culture conditions (calcium 0.1, 0.7, 1.4 and 2.0 mM). Results: H&E staining showed different phenotypes according to the calcium concentration and IHC also showed different phenotyes compared to that of keratin 10, involucrin, filaggrin, loricrin and PCNA. Conclusion: As a result, we concluded that the calcium gradient is also an important factor in skin organ culture to maintain the vivo-like environment and the appropriate calcium concentration is 1.4 mM. (Korean J Dermatol 2010;48(5):373~379)

베커 모반의 ND:YAG 레이저 치료 효과에 대한 임상 평가

김현웅 ( Kim Hyeon Ung ),서영준 ( Seo Yeong Jun ),이증훈 ( Lee Jeung Hun ),박장규 ( Park Jang Gyu ),남인환 ( Nam In Hwan ) 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.4

N/A Background: Xanthelasma palpebrarum does not regress spontaneously, its appearance is often seen as cosmetically disturbing. Treatment of xanthelasrna palpebrarum may prove difficult due to its delicate location at the periorbit and sometimes its extensive dimension. Treatments include excision, electrodesiccation, chemical cautery and laser surgery. Objective: This study was designed to evaluate the effect of a CO₂laser for the treatment of xanthelasma palpebrarum. Methods: Twenty patients with a total of 56 xanthelasma lesions, were treated with a CO₂laser. The Follow-up period of observation was between 12 and 84 months. Results: All lesions could be removed completely with a single laser treatment. Only transient pigmental change (hypopigmentation 1/20, hyperpigmentation 1/20) was observed without scarring. 8 patients developed a recurrence of xanthelasma. Conclusion: The CO₂laser represents an effective means for treating xanthelasma, but recurrence is common. (Korean J Dermatol 2004;42(3):250~255)

보웬병의 임상 및 병리조직학적 고찰

박민수 ( Park Min Su ),김윤동 ( Kim Yun Dong ),서영준 ( Seo Yeong Jun ),이증훈 ( Lee Jeung Hun ),박장규 ( Park Jang Gyu ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.9

Background : Bowen`s disease is a form of intraepidermal (in situ) squamous cell carcinoma in histopathology, the representative premalignancy of the cutaneous squamous cell carcinoma and is usually persistent and progressive, with a small potential for i

자궁경부암 냉동조직에서 Polymerase Chain Reaction (PCR)을 이용한 인 유듀종바이러스 (HPV)의 출현과 임상적 특징과의 연관성에 관한 연구

권선호,남상륜,이증훈,노재랑,최준호 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

Infection with human papillomavirus(HPV) is considered to be the principal causal agent in the development of the uterine cervical cancer. To detect HPV types prevalent in carcinoma of the uterine cervix, a type-specific, sensitive polymerase chain reaction(PCR)-based assay for HPV types 16, 18, and 33 was applied to 40 cervical carcinomas(39 squamous cell carcinomas and 1 adenocarcinoma), 6 cases of cervical intraepithelial neoplasia(CIN), and 18 samples of cervicitis and histologically normal cervix. PCR was done using 2 sets of Ll primer of HPV-16 and 18, 1 set of E2/E1 primer of HPV-33, and 3 sets of E6 primer of HPV-16, 18, 33. The amplified product was analyzed directly on the basis of the size of the ethidium bromide-stained band visible after agarose gel electrophoresis, which was confirmed by Southern blot hybridization. The results were as follows : 1. As expected, the combined incidence of the common high-risk genital HPVs(types 16, 18 and 33) was high in carcinomas (82.5%) and CIN 111(66.7%), low in CIN 1(33.3%), and nonexistent in the normal controls. 2. By using L1 primers and E1/E2 primers in 46 CINs and cervical carcinomas, HPV DNA was detected in 36(78.3%), which were 65.2%(30/46) for HPV 16, 8.7%(4/46) for HPV 33, 6.5%(3/46) for HPV-18, and only 1 case of mixed infection of HPV-16 and HPV-18 was detected. All normal cervices and cervicitis tissues were negative for HPV 16, 18 and 33. By using E6 primers, 35 (76.1%) cases were positive for HPV DNA, which were 67.4%(31/46) for HPV-16, 4.3%(2/46) each for HPV-18 and HPV-33. HPV 16 is the most common type present in squamous cell carcinoma. 3. There was no difference in detection rates of HPV DNA according to patients age in cervical carcinoma (p=0.188). 4. There were good correlation between the results obtained by PCR using Ll or E1/2 primer and those by E6 primer. The concordance rates were 93.8%(60/64) for HPV-16, 98.4% for HPV-18, and 96.9% for HPV-33. 5. There was no difference in detection rates of HPV DNA according to clinical stage in cervical carcinoma(p=0.2). 6. The detection rate of HPV DNA in case of serum SCC level under lOng/ml was 100%(17/17), which was higher than those in cases of serum SCC levels of 10ng/ml or more. "The detection rate was significantly decreased as serum SCC became high in level(p=0.012). 7. There was no difference in detection rates of HPV DNA according to tumor size in cervical carcinoma (p=0.743). 8. The reccurrence rate of patients with HPV-16 containing tumors was 28.6%((8/28), which was 3.4 times more than that of patients without HPV-16, but it was not statistically significant(p=0.162). The survival rate of patients with HPV-16 containing tumors was 82.1%, which was not different from from that of patients without HPV-16 containing tumrs(p=0.405). In conclusion, papillomavirus, especially HPV-16, played some role in the development of cervical cancer. There was no association between the HPV infection and the clinical characteristics including prognosis. However, in contrast to other studies, HPV type 18 and 33 were not the common type of HPV. Perhaps more cases should be analyzed.