두부외상 환자의 신경정신의학적 평가(I) : 외상후 기질성정신장애 환자에서 뇌의 구조적 및 기능적 검사소견의 비교

이장호,장환일,Yi, Jang Ho,Chang, Hwan-Il 대한생물정신의학회 1996 생물정신의학 Vol.3 No.1

The Evaluation of patients complaining of psychiatric symptoms following head injury is much affected by the results of various tests. The objecive of this paper is to investigate the effectiveness of each lest by comparing the structual and fuctional brain studies. The subjects were 93 organic menial disorder in and out patients at the Dept. of Neuropsychiatry of the Kyung Hee University Hospital. After carrying out MRI, CT, SPECT, EEG, the results of each were analysed for the sesitivity and ability to detect focal lesion. The degree of inter-test correlations of lest results were also investigated. Furthermore, the characteristic features of psychological tests were studied and the relationship between each of above mentioned tests and psychological test was examined. As for the test sensitivity to diagnosis, the SPECT was the most superior followed by MRI, CT, EEG in thai order. In the case of abnormality, SPECT ranked 1st in detection of focal lesion, followed by MRI, CT in that order. In the inter-test result correlation, the correlation of SPECT-MRI was statistically significant. When mare than moderate abnormality EEG finding was reported, it correlated significantly with that of MRI findings. In the MMPI, the average scores on F, Hs, D, Hy, Pa, Pt, Sc subscales were above 60. Abnormal SPECT group scored significantly high on the F, Pd, Pa, Sc, Ma scales and therefore in comparison ot the SPECT normal group, displayed more psychotic features. In K-WAIS, the mean full scale IQ was down to 77. 23(Verbal IQ : 78.76, Performance IQ : 77.44) but there was no characterogic significant relationship between the lowered to and abnormal SPECT, MRI, CT and EEG results. In conclusion, 1) The SPECT was mast superior in sensitivity and detection of focal lesions. In comparision with other tests, the results of SPECT correlated well with MRI had thus is thought to be very usefull testing method in the evaluation of organic mental disorder patients. 2) The MRI had relatively high sensitivity, ability to detect focal lesion and superior correlation with other test. 3) Although EEG fared less an sensitivity in comparison to other tests, the results of above moderate abnormal grade group and that of MRI correlated significantly. 4) In the MMPI highly scored in F, Hs, D, Hy, Pa, Pt, Sc subscales and abnormal SPECT patients were shown to display more sever psychotic features. There was no significant character relationship between the lowered IQ(in K-WAIS) and abnormal findings on MRI, CT, SPECT, EEG.

지연성 진전 1례

이장호,윤도준,Yi, Jang Ho,Yoon, Doh Joon 대한생물정신의학회 1995 생물정신의학 Vol.2 No.1

Tardive dyskinesia(TD), typically appearing as an undesirable side effect of a long term antipsychotic drug treatment has gained increased attention in recent times due to the discovery of many TD variants. This is a single case study of a patient who has undergone more than 8 years of high dosage antipsychotic treatment. After altering the type and dosage of antipsychotic medication 3 months prior to visit, the patient showed relatively abrupt onset symptoms of severe tremor and dystonia. These symptoms, appearing in clear consciousess, got better to a certain degree after 48 hours, worsened for 12 hours, and then improved again. Subsequently there was no continuing movement disorder. Several tests and consultation were carried out. However except for the medication factor, no other possible causes for such disabling symptoms were found. This clinical condition was thought to be akin to tardive tremor, a variant of TD. Furthermore, the course was atypical.

다물체동역학을 이용한 저압스팀터빈 케이싱의 진동해석

이장호(Jang Ho Yi),김동현(Dong Hyun Kim),곽영섭(Young Sub Kwak),류재선(Jae Sun Ryu) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.5

다물체동역학 및 공기역학을 활용한 5MW급 해상풍력발전기 동적하중해석

이장호(Jang-Ho Yi),김동현(Dong-Hyun Kim),서민수(Min-Soo Seo),류경중(Kyung-Joong Ryu) 한국소음진동공학회 2013 한국소음진동공학회 학술대회논문집 Vol.2013 No.4

BEM 및 CFD 기법을 이용한 5MW 급 해상풍력발전기의 설계하중조건 해석

이장호(Jang-Ho Yi),김동현(Dong-Hyun Kim),서민수(Min-Soo Seo) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.5

In this study, critical design load cased of a wind turbine using blade element momentum method(BEM) and computational fluid dynamics (CFD) are calculated considering structural dynamic loads. The present CFD analysis are conducted considering shear-shear-stress transport (SST) k-? turbulence model. Computational multi-body dynamic analysis is also used to calculate structural dynamic loads of a wind turbine system including blades, tower, substructure and foundation. The NREL 5MW offshore wind turbine model is typically considered for the comparison of numerical results. Efficient equivalent modeling method is also applied to effectively conduct multi-body dynamic analysis of the wind turbine system considering both inertial and gravity load effects. According to GL Guidelines 2010, major design load cases (DLC) have been analyzed and compared in order to investigate the effect of different aerodynamic modeling methods.

버펫하중을 고려한 우주발사체의 정상공력해석 및 실험데이터 비교 분석

이장호(Jang Ho Yi),김동현(Dong-Hyun Kim),곽영섭(Young Sub Kwak),윤세현(Se Hyun Yoon) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.5

그리드 기반의 건설연구 실험에 관한 연구

김동욱(Kim Dong Wook),이송이(Yi Song Yi),황기태(Hwang Ki Tae),이장호(Lee Jang ho),장선(Jang Sun) 대한토목학회 2005 대한토목학회 학술대회 Vol.2005 No.10

한국인 및 중국 한족 정신분열병 환자의 5-HT2A 수용체 유전자 -1438A/G 다형성

이장호,이광철,이승부,오용인,최영근,조아랑,정주호,장환일 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1

Objectives : The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5-HT2A receptor gene and schizophrenia in Korean and Han Chinese population. Methods : A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Resthction Fragment Length Polymorphism (RFLP). Results : There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G Poly-morphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics. Conclusion : These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.

정신분열병 환자의 통증 감지력 둔화와 압통 역치

송지영,이장호 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

연구목적: 정신분열병 환자에서 통증자극에 따른 감지력이 저하되어 있는지를 압통역치를 이용하여 알아보고, 만일 통증감지력이 저하되어 있다면 이는 어떠한 정신증상과 관련되는지를 밝혀 보고자 하였다. 방 법: 정신분열병환자 21명(남자 8명, 여자13명)과 건강대조군 23명(남자 9명, 여자14명)을 대상으로 하여, 환자군에서 양성 및 음성증상을 측정하고, 양군에서 압통측정기를 이용하여 압통역치를 측정하였다. 양군에서 압통역치의 차이를 분석하고, 증상의 호전도에 따른 압통역치의 변화를 보았다. 결 과: 정신분열병환자가 정신증상이 심할 때 압통역치는 대조군에 비해 의미있게 높았으며, 증상이 호전되면 압통역치는 정상대조군 수준으로 감소되었다. 정신증상 중에는 망상의 심도가 압통역치의 변화와 관계가 있었으며, 투여된 항정신약물은 압통역치에 영향을 주지 않았다. 결 론: 정신분열병에서 보이는 통증감지력의 둔화현상은 지속적이라기 보다는 일시적인, 가역적인 뇌기능의 변화에 따른 감각수용 장애나 집중력 저하와 관련되는 것으로 추정된다. 정신분열병에서 통증감지력의 둔화현상을 조기에 발견하는 것은 치명적인 신체질환에 따른 위해(危害)를 막을 수 있다는 점에서 임상적으로 중요한 부분이다. Objectives: Decreased pain sensitivity to the external stimuli was sought by measuring the pressure pain thresholds in patients with schizophrenia. In the case of the pain insensitivity(PI) being confirmed, the relationship between psychiatric symptoms and PI was to evaluated. Methods: 21 schizophrenic and healthy controls enrolled. Pressure pain thresholds(PPT) were measured by pressure algometer on initial and recovered phase, and positive and negative symptoms by PANSS(Positive and Negative Symptoms Scale)(Stanley et al. 1991) were obtained in patient group. The confounding factor induced by antipsychotics to the PPT was controlled for. Comparisons of PPT between two groups, and correlations of PPT and psychiatric symptoms in patient group were tested. Results: 1) Schizophrenic patients with active psychotic symptoms showed higher PPT compared to healthy controls. 2) When psychiatric symptoms were improved, PPT was decreased to the level of healthy controls. 3) Only the subscale of delusion in PANSS was closely correlated with PPT in patients with schizophrenia. 4) The dose of antipsychotics did not influence the PPT of the patient group. Conclusion: A part of patients with schizophrenia revealed they had higher pressure pain thresholds, which suggested PI in active symptom phase. However, PPT were restored almost to the level of normal controls when psychotic symptoms were improved. Thus, PI seemed to be a transient phenomenon rather than a persistent one. Changes of pain sensitivity to the external stimuli in schizophrenics would be associated with severity of delusion based upon reversible changes of brain function. Decreased attention due to delusion or lack of motivation seemed to be causal factors of PI. Clinicians should give attention to PI in schizophrenic patients to prevent physical illness and serious injuries in them.