초청설교 : 넉넉히 구원 얻는 삶 : 이신웅

이신웅 기독교대한성결교회 활천사 2016 활천 Vol.749 No.4

L2 Reading Strategies and Gender: A Study of Korean EFL University Students

이신웅 한국영미어문학회 2008 영미어문학 Vol.- No.86

The main purpose of the study is to investigate gender difference in the frequency and pattern of reading strategy use and to see if the gender difference exists, if any, across reading proficiency level. Four hundred sixty six university students who were enrolled in two Korean universities located in Seoul participated in the study. Two major instruments were utilized in the current study. First, the reading strategy survey adapted from Survey of Reading Strategies (SORS; Mokhtari & Sheorey 2002) was administered to the participants to measure their perceived use of reading strategies. Second, a reading comprehension test was used to assess the participants' English reading ability. It was found that there was no considerable differences in the pattern of strategy use between the two groups. However, the results of independent samples t-tests revealed that the female students used reading strategies significantly more often than the male students in general. Then, a multiple analysis of variance was conducted to see if there was gender difference in the three dependent variables (global, problem-solving, and support strategy). The results showed that there was no significant gender difference in the use of global and problem-solving strategies, but there existed a significant gender difference in the use of support strategy and the difference was consistent across the reading proficiency level. It was concluded that the female students showed a higher use of reading strategies in general, particularly in the use of support strategy than the male students, and this tendency was consistent across reading proficiency level.

Rat腎臟에서 High Affinity [³H]Ouabain Binding Site의 缺如

李神雄 영남대학교 자원문제연구소 1984 資源問題硏究 Vol.3 No.-

I50 value for inhibition by ouabain, turnover number, and (3H) ouabain binding of cardiac sarcolemmal Na+, K+-ATPase were compared to those of kidney microsome in rat. The I50value (50~60?M) and turnover number were same for both subcellular fraction. The KD value and binding site concentration (Bmax) calculated by displacement assay for ouabain binding of cardiac sarcoleinma in presence of 0.1-0.2 ?M [3H] ouabain were 0.33±0.05?M and 8.7±0.6 pmol/mg protein, respectively, but the binding in vitro of [3H]ouabainto kidney microsomal Na+, Kl+-ATPase was not detected. These data suggest that rat kidney has low affinity site but not detectable high affinity site to ouabain which can be detected inrat heart.

Neostigmine이 Atropine 處理 家兎의 血歷에 미치는 影響

李神雄,李壽根,陳甲德 영남대학교 자원문제연구소 1984 資源問題硏究 Vol.3 No.-

The intravenous injection of neostigmine produced a rise in blood pressure in atropinized rabbits. This pressor response was markedly inhibited by phentolamine, reserpine or hexamethonium but was not affected by hemicholinium. The injection of neostigmine into the lateral cerebral ventricle evoked a hypertensive response which could be reduced by the previous administration of atropine, intraventricular hemich-olinium, phentolamine or reserpine, but not by methylatropine. It is concluded that the pressor response of intravenous neostigmine in atropinized rabbits is due to direct stimulant action on the sympathetic ganglia, which is distinct from its anticholinesterase action and central hypertensive effect.

Ⅲ. Amaranth, Brilliant Blue 및 Tartrazine의 腸片에 미치는 影響

李神雄,曺圭朴,金和雄,崔在圭 忠南大學校 1972 論文集 Vol.11 No.-

Pharmacological effect of amaranth, brilliant blue and tartrazine was investigated in guinea pig ileum. Amaranth, brilliant blue and tartrazine over 100㎍/ml concentration induced contraction of guinea pig ileum. Hexamethonium, atropine and promethazine did not prevent amaranth, brilliant blue or tartrazine induced contraction. Tetracaine antagonized the contractile response to amaranth, brilliant blue or tartrazine. In the presence of amaranth, brilliant blue or tartrazine, contractile response to acetylcholine was increased and inhibitory response to norepinephrine decreased. Amaranth, brilliant blue and tartrazine augmented peristaltic movement and intraluminal pressure of guinea pig ileum.

家兎 側腦室內 Physostigmine의 利尿效果에 關한 硏究

李神雄,孫基鎬 영남대학교 자원문제연구소 1984 資源問題硏究 Vol.3 No.-

Effect of intraventricular physostigmine on the renal function of rabbits was investigated. The results were as follows. 1. Intraventricular Physostigmine (below 0.3㎍ per rabbit) did not affect the renal function but induced diuretic action in does ranging 10㎍ to 100㎍ per rabbit, exhibited a rough dose-response relationship, and increased renal plasma flow, glomerular filtration rate, urinary excretion of sodium and potassium, concomitant with increased urine flow. On the other hand, intraventricular physostigmine did not influence to filtration fraction and reabsorption of sodium and potassium. 2. Correlation coefficient among the increased urine flow, renal plasma flow and glomerular filtration rate was statistically significant. 3. Intravenous physostigmine (100㎍) did not affect the renal function. 4. Parameters of renal function increased by intraventricular physostigmine were inhibited by intravenous atropine (2mg/kg) or bilateral vagotomr. These results suggest that the diuretic effects of intraventricular physostigmine in rabbit is mainly due to hemodynamic changes by centrally induced cholinergic mechanism on the kidney.

자궁 Muscarinic Receptor에 관한 연구 : Receptor결합실험과 기능적실험과의 상관성 elationship between functional and Receptor-Binding Data

이신웅 영남대학교 자원문제연구소 1993 資源問題硏究 Vol.12 No.-

Using a receptor binding technique, with ℓ-quinuclidinyl benzilate(QNB) as a radioligand, we have classified the cholinergic muscarinic receptors In the unpregnant uterus of dog into M2 receptors. This study was carried out to elucidate whether the previous binding data correlate with data from pharmacological studies of uterus strips. Carbachol and methacholine, muscarinic receptor agonists, increased the motility and contractile force of uterus with ED50alue of 2.6 and 3.0 #d. respectively. Atropine and pirenzepine caused the rightward shift of the concentration-response curve to carbachol. With these antagonists, the slopes of the Schild plots were not significantly different from the theoretical value of one, indicating competitive antagonism. The dissociation constants(KA) of atropine and pirenzepine estimated by Schild analysis were 0.6nM and 213nM, respectively. The ED50values of agonists and KAvalues of antagonists correlated with K values determined by the radioligand binding technique. These results suggest that the binding of the muscarinic agonists and antagonists including[3H]QNB to the uterus represents an interaction with a receptor of physiological relevance.

항 히스타민제의 H₁ 수용체와 무스카린 수용체에 대한 상대적 역가

이신웅,박영주,이정수 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-

The muscarinic antagonist l-[benzilic-4, 4'-³H]quinuclidinyl benzilate([³H]QNB) bound to a single class of muscarinic receptor with high affinity in guinea pig ileal membranes. The K_(D) and B_(max) values for [³H]QNB calculated from analysis of saturation isotherms were 54 pM and 156 fmol/mg, respectively. H₁-blockers inhibited [³H]QNB binding to ileal membranes with K_(i) values ranged from 0.008 μM to 1.6 μM. The pseudo-Hill coefficients of H₁-blockers for inhibition of [³H]QNB binding to the ileal membranes were close to unit. The K_(i) values for H₁-blockers were similar to the K_(M) values calculated by Schild plot of functional data obtained from inhibition of the carbachol-induced contraction in guinea-pig ileum, suggesting that binding of H₁-blockers vs [³H]QNB in ileal membranes represents an interaction with a receptor of physiological relevance. The K_(H) values of H₁-blockers for H₁-receptor estimated from inhibition of the histamine-induced contraction were the range of 0.15 nM to 56.5 nM. The K_(M)/K_(H) ratio of H₁-blockers varied over a wide range of 3 to 2300. Thus, the antihistaminic potencies of H₁-blockers do not correlate with their antimuscarinic potencies, which suggest that antihistamines have different antimuscarinic potencies in therapeutic blood levels causing similar antiallergic effect. Among 13 traditional antihistaminics examined in this study, drug having the highest and the lowest K_(M)/K_(H) ratio is triprolidine and diphenidol, respectively. The present results demonstrate that the antimuscarinic property of antihistamines is not necessary for their antiallergic effect, and data on the affinity of antihistamines for muscarinic and H₁-receptors can be an important parameter in the selection and evaluation of these drugs.

Effect of Bay K 8644, a Calcium Chaanel Agonist, on Dog Cardiac Muscarinic Receptors : Lee, Shin Woong Park, Young Joo Lee, Jeung Soo

이신웅,박영주,이정수 영남대학교 약품개발연구소 1992 영남대학교 약품개발연구소 연구업적집 Vol.2 No.-

To investigate further whether the effects of the dihydropyridine (DHP) drugs on calcium channels are related to those of these drugs on muscarinic receptors, the binding characteristics of the DHP calcium channel agonist, Bay K 8644, on muscarinic receptors and calcium channels were compared to those of the DHP calcium channel antagonists, nicardipine and nimodipine in the dog cardiac sarcolemma. Bay K 8644, nicardipine and nimodipine inhibited the specific [³H]QNB binding with K_(i) values of 16.7 μM, 3.5 μM and 15.5 μM respectively. Saturation data of [³H]QNB binding in the presence of these DHP drugs showed this inhibition to be competitive. Bay K 8644, like nicardipine and nimodipine, blocked the binding of [³H]nitrendipine to the high affinity DHP binding sites, but atropine did not, indicating that the muscarinic receptors and the DHP binding sites on calcium channels are distinct. The K_(i) value of Bay K 8644 for the DHP binding sites was 4 nM. Nicardipine and nimodipine (K_(i) : 0.1-0.2 nM) were at least 20 times more potent than Bay K 8644 in inhibiting [³H]nitrendipine binding. Thus, the muscarinic receptors were about 4000 times less sensitive than these high affinity DHP binding sites to Bay K 8644. These results suggest that the DHP calcium agonist Bay K 8644 binds directly to the muscarinic receptors but its interaction with the muscarinic receptors is not related to its binding to the DHP binding sites on calcium channels.

L1 influence on the processing of L2 collocation: An experimental study of Korean EFL learners

이신웅 경희대학교 언어정보연구소 2016 언어연구 Vol.33 No.S

The current study aimed to investigate the influence of L1 on the processing of L2 collocations utilizing a phrase-acceptability judgement task. The task was conducted on 39 English collocations with 21 native speakers of English and 45 Korean EFL learners. Their error rates and reaction times were measured both on the congruent collocations that have L1 translation equivalents and the incongruent collocations that do not have ones. It was found that the advanced EFL learners responded significantly faster to and made fewer errors on both the congruent and the incongruent collocations than the intermediate EFL learners. Meanwhile, both the advanced and the intermediate EFL learners made significantly more errors and responded slower under incongruent condition, indicating a strong congruency effect. The results implied that there exists a high degree of reliance on L1 intralexical knowledge in processing L2 collocations by the EFL learners, and acquiring incongruent L2 collocations seems still challenging even to the advanced learners. However, it was also suggested that once EFL learners notice incongruent collocations as valid ones and store them in their L2 mental lexicon, they may be able to processing incongruent collocations as efficiently as native speakers, directly linking L2 collocation forms to their concepts independently of L1 mediation.