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Young Jin Lee,Su Hyun Yu,Gwang Yeong Seok,Su Yeon Kim,Mi Jeong Kim,Inhye Jeong,Wan Heo,Bo-Su Lee,도선길,Bok Kyung Han,Young Jun Kim 건강기능식품미래포럼 2024 건강기능식품미래포럼 학술지 Vol.4 No.1
Most research on ginseng primarily focuses on the ginseng root. However, research interest on ginseng have shifted from roots to leaves. This shift is because leaves are harvested annually while roots require several years before harvesting and the leaf extract contains higher contents of glycosides than the root extract. Recently, we treated ginseng leaf extract (GLE) with acid and obtained a variant of GLE named UG0712. In the current study, to verify the superiority of UG0712 over its precursor, a comparative study was conducted between UG0712 and GLE in terms of capacity of exercise performance in mice. Our findings revealed that UG0712 surpasses GLE in the effects on maximum running time on treadmill, grip strength, and the maximum volume of oxygen consumed during exercise/min/kg as well as levels of muscle glycogen and blood lactate and lactate dehydrogenase in mice. Furthermore, we observed that UG0712 also exhibited greater effectiveness in enhancing the expressions of the proteins associated mitochondrial genesis in C2C12 muscle cells of mice, which were phosphorylated AMP-activated protein kinase, sirtuin 1, peroxisome proliferator-activated receptor gamma coactivator-1 alpha, nuclear respiratory factor-1, and mtTFA, mitochondrial transcription factor A. mitochondrial. From these results, we conclude that the UG0712 improves the capacity of exercise performance and alleviates fatigue more effectively than GLE, possibly through enhancing mitochondrial genesis to a greater extent.
김용호 ( Yong Ho Kim ),도선길 ( Seon Gil Do ),김동선 ( Dong Seon Kim ),우성식 ( Sung Sick Woo ),김옥진 ( Ok Jin Kim ),이혜정 ( Hye Jeong Lee ) 한국식품영양학회 2008 韓國食品營養學會誌 Vol.21 No.4
Over the past few years, anthocyanin has been demonstrated to exert potentially anti-oxidative and bioavailability effects including anti-cardiovascular disease and cancer-preventive effects in humans. This study was conducted to assess the toxicity of anthocyanin extracts from black soybean seed coats via oral administration in a mice feeding test. The final anthocyanin-containing products induced signs of toxicity on mortality in the 4-week feeding test. The incidence of clinical signs and changes in body and organ weight were also not observed in all anthocyanin-treated groups as compared with the control groups. In hematology analysis, RBC indices concluding MCV, MCH, and MCHC and WBC differential counting such a NEU, LYM, MONO, EOS, and BASO evidenced no significant differences between the anthocyanin treatment and control groups. The biochemical parameters in serum analysis-ALT, AST, BUN, Crea etc.-were also not significantly altered in those groups. Absolute and relative organ weights were not increased after 4 weeks of treatment with anthocyanin extracts in mice. In conclusion, anthocyanin extracts from the black soybean has biological activity without any toxic effects, which also suggests that the consumption of soy containing anthocyanin products may be a good source for health and medical supplies.
Acemannan과 aloesin의 혼합 비율에 따른 대식세포에서의 항염증 효과
김효민(Hyo-Min Kim),김정환(Jeong-Hwan Kim),유단희(Dan-Hee Yoo),전세영(Se-Yeong Jeon),김현진(Hyun-Jin Kim),도선길(Seon-Gil Do),이인철(In-Chul Lee),강정욱(Jung-Wook Kang) 한국식품저장유통학회 2024 한국식품저장유통학회지 Vol.31 No.2
현재 항염증 활성에 대한 효능이 검증된 acemannan과 aloesin을 다양한 비율로 혼합하여 비율에 따른 항염증 효능을 확인하고자 본 연구를 진행하였다. 항염증 활성은 NO, PGE2, TNF-α 및 IL-6 생성량 및 염증 관련 단백질인 iNOS, COX-2의 발현량에 대한 효능을 검증하였다. Acemannan과 aloesin 각각의 NO 생성 저해 활성 결과와 혼합 시료인 AA-1, AA-2, AA-3, AA-4, AA-5의 NO 생성 저해 활성 결과를 비교하였을 때, 혼합 시료가 더 우수한 NO 생성 저해 활성을 나타내는 것을 확인하였다. 이후 최적의 배합 비율을 찾기 위해 PGE2, TNF-α 및 IL-6 생성량에 대해 측정하였다. 그 결과, 시료 5종 모두 최종 농도인 100 μg/mL 농도에서 LPS 단독 처리군 대비 저해 효과가 나타났으며, 이 중 AA-2의 저해 효과가 가장 높은 것을 확인하여 western blot을 통한 염증 관련 단백질 발현량은 AA-2를 이용하여 실험을 진행하였다. 염증 관련 단백질인 iNOS 및 COX-2의 발현량을 측정 결과, AA-2는 농도 의존적으로 감소하였으며, 최종 농도인 100 μg/mL 농도에서 LPS 단독 처리군 대비 각각 25% 이상의 억제 효과가 나타나는 것을 확인하였다. 이러한 결과들을 토대로 acemannan과 aloesin을 다양한 비율로 배합하였을 때, 항염증 활성을 가진 것을 확인하였으며, 이 중 acemannan과 aloesin이 1:2의 비율로 혼합되었을 때 가장 높은 항염증 활성을 나타내었다. 결론적으로 acemannan과 aloesin을 혼합한 시료는 다양한 기능성 소재로써 활용이 가능하며, 이후 항염증 활성 실험들의 기초자료로도 활용이 가능한 것을 확인하였다. This study aims to confirm the anti-inflammatory activities of acemannan and aloesin, which have been studied for various efficacies at various mixed sample ratios. The mixed samples were mixed at a ratio of 1:1 (AA-1), 1:2 (AA-2), 1:3 (AA-3), 2:1 (AA-4), and 3:1 (AA-5). Seven samples were evaluated for their cytotoxic ability on macrophages, and the results showed that all cell viability was over 90% at a concentration of 100 μg/mL. First, due to the NO production inhibitory activity, a better inhibitory effect was achieved when using a mixed sample rather than a single material. Afterward, the activity of inhibiting the production of PGE2, TNF-α, and IL-6 was confirmed using a mixed sample. It was confirmed that AA-2 had the best inhibitory activity on producing PGE2, TNF-α, and IL-6 rather than AA-1, AA-3, AA-4, and AA-5. For this reason, experiments were conducted using AA-2 to determine the protein expression levels of iNOS and COX-2, which are inflammation-related proteins. It was confirmed that AA-2 inhibited iNOS and COX-2 protein expression by 25.01% and 27.27%, respectively, compared to the LPS-alone treatment group. In conclusion, the mixed sample of acemannan and aloesin is judged to have anti-inflammatory activity and can potentially to be used as a functional material.
만성적 직업범죄의 유형 및 심리적 특성 분석 - 노인층 범죄자를 중심으로
이도선(Lee Do Sun) 한국범죄심리학회 2006 한국범죄심리연구 Vol.2 No.2
This research is for the cumulative offenses through work or business, which are convicted without causation. The goal is to prepare the efficient policy of police force.<BR> Cases of chronic offences and the outcomes are as complicated and misinterpreted in many cases as the title reads. There are many extreme and in-depth investigated categories that include, life style crime, company organized crime, gambling, drug lords, prostitution and crime for living.<BR> There are many degrees that come into the criminal mind. The following are just a few minor examples:<BR> 1. Psychological, regarding either mental or/and physical disabilities and the denial of guilt.<BR> 2. Having discrepancy of socialization, regarding guidance and fellowship within the social existence<BR> 3. Trauma, regarding the upbringing of one’s personal life and experiences throughout.<BR> Like the other second offenders, the chronic offenders assume that their perception of proceeding criminal activity will enhance their capabilities in gaining wealth and benefits towards the thoughts of freedom. This then cycles back around to the question of the psychological agenda of the mind.<BR> By analyzing these components, the overall outcome of this thesis delivers the current speculations and understandings of the chronic offences and the psychological characteristics of the criminal world. 모든 인간의 행위는 정신적 과정의 기능을 거쳐 행동으로 나타나기 때문에 범죄를 저지르는 사람들의 범죄행위 역시도 그 과정의 산물이라 할 수 있다.<BR> 범죄를 저지르는 사람의 범죄행위 유발 요인은 개인적, 사회적 측면으로 구분할 수 있다. 이중에서 우발적이고 격정적인 범행과 범죄 자체를 생계의 수단으로 활용하여 실행하거나, 이미 범죄자체를 생활의 일부분으로 여기는 상습적이고, 전문적이며, 직업적인 범죄는 구분할 필요가 있다. 따라서 본 연구에서는 범죄자체를 생활의 한 패턴으로 인식하여 범죄자체를 직업적으로 여기고 상습적이고 만성적으로 행하는 범죄자들의 심리적 요인을 분석하고 성폭력 범죄, 마약류 범죄, 조직폭력 범죄, 절도범죄를 통해 각 범죄의 유형별로 상습적이고 만성적인 직업범죄자의 심리적 특성과 그에 따른 대응방안에 대해서 논의하였다.
민간경비분야의 CPTED 도입실태 및 개선방안에 관한 연구
이도선(Lee, Do Sun) 한국민간경비학회 2011 한국민간경비학회보 Vol.18 No.-
CPTED는 건축물의 설계 및 도시계획 수립시 경제성과 편의성만을 고려한 건축설계로 우범지대 발생 및 범죄에 대한 공포 유발공간 (offensible space) 등 범행기회의 증가로 한정된 경찰의 범죄예방에 한계가 드러남에 따라 도보순찰․차량순찰 등과 같은 인력투입식 예방활동에서 탈피하여 범죄를 유발하는 물리적 환경의 개선을 통하여 범죄행위의 위험도와 곤란도를 높이는 전략이다. 즉, 물리적․공간적 범행기회의 차단을 통해 잠재적인 범죄자의 입장에서는 검거의 위험을 증 가시키는 접근방법이다. 이 연구의 목적은 민간경비분야에서의 CPTED 도입실태와 효율적 개선방안을 제시하는데 있다. 이 연구에서는 CPTED의 이론적 배경과 원리를 고찰하고, 국내의 CPTED 도입실태 및 문제점, 민간경비분야에의 적극적 도입을 위한 선행연구 및 실무자료에 대한 접근을 통해 타당성 및 향후 도입방향에 대해 논의하였다. 연구 및 산업분야 활성화의 근본적인 대책 중 하나가 법제도적, 정책적 지원방안이라 할 수 있다. 그동안의 연구진행정도나 사회적(산업적) 필요성을 고려한다면 이제는 직접 관련이 있는 제도를 마련하고 다양한 지원대책이 있어야 할 시점이라고 판단된다. 해외사례에서 나타난 바와 같이 CPTED 선진국에서는 그 효과성을 인식하고 제도적인 강제규정이나 인증제도와 같은 선택적 규정 등 다양한 대책을 마련하고 있는데, 이러한 사례들을 참고하여 국내 현실에 부합한 대안이 제시되어야 할 것이다. The limited boundary of police's crime prevention was exposed because of the architectural design, which only considered the economic efficiency and convenience at the time of designing and establishing the city plan of a building, increased a chance for the occurrence of a crime-ridden district and offensible space toward crime. The corresponding strategy is CPTED, which increases the degrees of hazard and difficulty of criminal act through the improvement of physical environment that causes crime by breaking away from the kind of prevention act of committing manpower such as a foot patrol and police car patrol. In other words, it is a method of approach that increases the hazard of getting arrested from the potential criminal's point of view by blocking the physical and spatial chances for crime. This study purports to provide the condition of introducing CPTED in the private security field and its effective method for improvement. In this study, we contemplated on the theoretical principle and background of CPTED, discussed the condition of introducing CPTED in Korea and its problems, researched the precedent cases for active introduction in the private security field, and discussed its validity and the direction for the future introduction through approaching the actual data. One of the fundamental steps for the vitalization of research and industrial field could be the measures for supporting legally and politically. Considering the degree of research progress or the social(industrial) necessity, it is judged that now is the time for various supporting measures and preparing a system that is directly relevant. As they are shown in foreign examples, the advanced countries for CPTED have recognized its effectiveness and prepared various measures such as systemically enforced regulations or selective regulations like certification system. By consulting these examples, the measures that coincide with the reality of Korea must be provided.