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평판형 고체산화물 연료전지의 유로 설계변수에 따른 성능비교를 위한 유동 해석 연구
이대호(Dae Ho Lee),손정락(Jeong Lak Sohn),노승탁(Sung Tack Ro) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
Solid oxide fuel cell (SOFC) is expected to be a promising candidate for the power source in the next generation due to its high efficiency, utilization of high-temperature waste heat and low emission of pollutant to the environment. SOFC is, however, very sensitive to thermal stress because of its high operating temperature. In this study, three-dimensional CFD analyses are conducted to investigate the influence of flow pattern in the performance of a planar SOFC. Numerical results show that the temperature increases along the flow direction in the co-flow case and the temperature profile has a peak near the fuel inlet in the counter-flow case. Simulations of staggered flow channel model prove that overall performance is almost the same as that of unstaggered one although local distribution of current density is different.
정신분열병 환자에서 Heat Shock Protein 70(HSP70) 유전자 다형성
이대호(Dae-Ho Lee),이선우(Sun-Woo Lee),왕성근(Seong-Keun Wang),신윤오(Yun-O Shin),지익성(Ik-Seoung Chee),김정란(Jeong-Ran Kim),이영호(Young-Ho Lee),김지욱(Ji-Wook Kim) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.2
목적 : 본 연구는 정신 분열병과 관계 있다고 알려진 HSP70 유전자 중, HSP70-2(HSPA1B) 유전자 다형성에 초점을 맞추어 정신분열병과 관계가 있는지를 알아보기 위해 시행되었다. 방법 : DSM-Ⅳ 진단기준에 의해 진단된 정신분열병 환자군 104명과 정상 대조군 107명을 대상으로 하였다. HSPA1B 유전자형 판별을 위해 restriction fragment length enzyme(RFLP)을 이용한 polymerase chain reaction(PCR)이 사용되었다. 결과 : 정신분열병 환자군에서 HSPA1B 유전자형의 분포는 AA 32(30.8%), AG 57(54.8%), GG 15(14.4%)였으며, 대립 유전자의 빈도는 A 121(58.2%), G 87(41.8%)였다. 정상 대조군에서 HSPA1B 유전자형의 분포는 AA 35(32.7%), AG 63(58.9%), GG 9(8.4%)였으며 대립 유전자의 빈도는 A 133(62.1%), G 81(37.9%)였다. 정신분열병 환자군과 대조군 간 HSPA1B 유전자형의 분포와 대립 유전자의 빈도에 있어서의 차이는 유의하지 않았다. 또한, 환자군을 성별, 정신과적 질병의 가족력, PANSS scale에 따른 증상 심각도 등의 변수에 따라 분류하였을 때도 유전자형의 분포와 대립 유전자의 빈도 차이는 유의하지 않았다. 결론 : 이 연구의 결과는 한국인 정신분열병 환자들에서 HSPA1B 유전자 다형성이 정신분열병의 병인과 관계가 없음을 나타낸다. 가족-기초 비교 위험 연구와 정신분열병의 다른 임상적 변수들을 포함한 향후의 연구가 필요할 것이다. Objectives:The heat shock protein 70(HSP70) is believed to be involved in the pathogenesis of schizophrenia with regards to neurodevelopment. An aberration in the HSP70 has been proposed in schizophrenia patients, suggesting that it is a candidate gene for schizophrenia. This study aimed to investigate the association between polymorphsims of HSP70-2(HSPA1B) and schizophrenia. Methods:One hundred and four patients with schizophrenia and One hundred and seven normal controls were enrolled in the study. A polymerase chain reaction(PCR) with restriction fragment length enzyme(RFLP) was used to genotype the HSPA1B polymorphisms. Results:1) In schizophrenic patients, genotype distributions of the HSPA1B polymorphism were AA 32(30.8%), AG 57(54.8%) and GG 15(14.4%), and allele frequencies were A 121(58.2%), and G 87(41.8%). In normal control, genotype distributions of the HSPA1B polymorphism were AA 35(32.7%), AG 63(58.9%) and GG 9(8.4%), and allele frequencies were A 133(62.1%), and G 81(37.9%). There were no significant differences in the allelic or genotype frequencies of the HSPA1B polymorphisms between the schizophrenia patients and the controls. 2) There were no difference in genotype distribution and allele frequencies of the HSPA1B polymorphism, when patients were categorized by sex, family history of psychiatric disease, severity of symptom with PANSS scale. Conclusion:These results suggest a HSPA1B polymorphism is not causally related to the pathogenesis of schizophrenia in the Korean population. Further study of HSPA1B polymorphism should be needed, including family based association study and other clinical variations of schizophrenia.
증례 / 전신성 흥반성 루푸스 환자에서 발생한 거대세포바이러스 폐렴 1예
이대호(Dae Ho Lee),김진욱(Jin Wook Kim),신동현(Dong Hyun Shin),오명돈(Myoung Don Oh),송영욱(Yeung Wook Song),최강원(Kang Won Choi),이정상(Jung Sang Lee) 대한내과학회 1999 대한내과학회지 Vol.56 No.1
We report a case of cytomegalovirus(CMV) pneumonitis in a 21-year-old woman with systemic lupus erythematosus(SLE). She was diagnosed 3 years ago with lupus nephropathy and was on immunosuppressive therapy with prednisolone and cyclophosphamide. She developed dyspnea with fever and hypoxemia. Chest X-ray, and HRCT showed interstitial pneumonitis. We performed open lung biopsy. The diagnosis of CMV pneumonitis was made by the virus culture and immunohistochemical staining for CMV in lung tissue. Despite the admini stration of ganciclovir and high dose immunoglobulin therapy and assistance of mechanical ventilator, the patient died.
모야모야 병, 관상동맥 협착 및 확장형 심근병증을 동반한 말단비대증
이대호(Dae Ho Lee),김용주(Yong Joo Kim),이대배(Dae Bae Lee),박재홍(Jae Hong Park),정동진(Dong Jin Chung),정민영(Min Young Chung),이태희(Tai Hee Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.2
A 19-year-old girl with typical features of acromegaly, duration of which was thought to be above 10 years, presented with dyspnea. After serial studies, dilated cardiomyopathy and critical stenosis of left anterior descending coronary artery were demonstrated. Brain MRI revealed the following changes: the pituitary gland was enlarged and its upper margin was upwardly convex; severe cerebral atrophy and multiple signs of vascular abnormalities were present. Cerebral angiographic studies demonstrated the presence of complete occlusion of left carotid artery and severe stenosis of right carotid artery with the formation of collateral networks of vessels. The patient was thus diagnosed as having moyamoya disease that was thought to be congenital according to her past histories. Her cardiac function was slightly improved after percutaneous transluminal coronary angioplasty. Operation for the pituitary lesion and moyamoya disease was not performed due to poor general condition, but serum growth hormone concentration was adequately suppressed after octreotide therapy. We consider that this is a very rare case of acromegaly associated with moyamoya disease, coronary arterial disease and dilated cardiomyopathy.(Korean J Med 58:227-233, 2000)
이대호 ( Dae Ho Lee ) 대한내과학회 2014 대한내과학회지 Vol.87 No.3
Cancer immunotherapy has come a long way since William Coley observed that a mixture of killed bacteria, or Coley`s toxin, induced tumor regression. However, enthusiasm for cancer immunotherapy has changed to skepticism over recent decades due to its lack of efficacy, inconsistency, and significant toxicity. Of course, much of that skepticism was the result of a lack of understanding of the immune system. The recent expansion of our understanding of immunity and immune system and the success of new cancer immunotherapies has raised hope that we can treat cancer effectively via immunotherapy or combination approach using immunotherapy and other cancer therapies. Indeed, there is no doubt that cancer immunotherapy is experiencing a renaissance. Here, I will briefly review the current status of various immunotherapies, including cytokine therapy, antibody therapy, cancer vaccines, and adoptive cell therapy, and then I will summarize the results of recent clinical trials using anti-immune checkpoint monoclonal antibodies. (Korean J Med 2014;87:284-295)