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만성신부전환자에서 혈장 단백 C 및 S 의 임상적 의의
이귀순(Kwi Soon Lee),하성규(Sung Kyu Ha),박종훈(Chong Hoon Park),서정건(Jung Kun Seo),이호영(Ho Yung Lee),한대석(Dae Suk Han),송경순(Kyung Soon Song) 대한내과학회 1997 대한내과학회지 Vol.53 No.2
N/A Objectives: Patients with chronic renal failure have increased hemorrhagic tendency due to an uremic platelet dysfunction and complications from anticoagulants used in hemodialysis. They are also prone to have thrombotic complications in the cerebral vessels, coronary arteries and A-V fistula, due to hypercoagulability from changes in various factors. Recently, deficiencies in plasma protein C and S, which are physiological anticoagulants, have been reported to cause thrombosis. In chronic renal failure, plasma protein C and S activities are known to be decreased. Methods: In the present study, activities and antigen concentrations of plasma protein C and S, as well as AT-III activities were investigated in three groups; the normal control group, the predialysis group of chronic renal failure patients treated conservatively, and the hemodialysis group. The findings were analyzed for their relationship to hypercoagulability. Results: 1) The activities of plasma protein C, S and antithrombin-III were significantly lower in the predialysis chronic renal failure group as compared to the control. Antithrombin-III concentrations in the hemodialysis group assayed immediately prior to dialysis were significantly lower than those of the control group. But, protein C antigen concentrations in the hemodialysis group assayed immediately prior to dialysis were significantly higher than those of the control group. There was no significant difference between these groups in plasma protein C activities, and plasma protein S activities and antigen concentrations. 2) In the hemodialysis group, antithrombin-III activities, antigen concentration and activities of plasma protein C were significantly higher than after dialysis as compared to those before the dialysis. 3) There were no significant difference in plasma protein C, S and antithrombin-III activities and plasma protein C and S antigen concentrations in hemodialysis patients between with and without thrombosis at arterio-venous fistula site. However, plasma protein C and antithrombin-III activities were significantly lower in those with thrombosis as compared to those of the normal control group. There were no significant difference in plasma protein C and S activities and antigen concentrations in those without thrombosis as compared to those of the normal control group. 4) There were no significant diffrences in plasma protein C, protein S and antithrombin-III activities and antigen concentrations in dialysis patients with and without recombinant erythropoietin treatment. 5) There were no significant correlations between serum creatinine and creatinine clearance, and plasma antithrombin-III, protein C and protein S activities and antigen concentrations in predialysis group. Conclusion : These results suggest that the decrease in plasma antithrombin-III, protein C and S could be the factors causing hypercoagulability in chronic renal failure patients, and the decreased activities of these factors may return to normal by dialysis. In the hemodialysis group, there were no significant diffrences in plasma protein C and S and antithrombin-III activities and antigen concentrations between the group which showed clinical thrombosis and the group which did not. However, in those who had thrombosis, plasma protein C and antithrombin-III activities are significantly lower than the control group. Administration of recombinant human erythropoietin does not appear to affect the activities of plasma protein C and S and antithrombin-III. In predialysis chronic renal failure patients, there was no significant relationship between renal function and plasma protein C and S and antithrombin-III.
만성 육아종성 질환에서의 Stimulated N. B. T. 검사
이귀순 ( K S Lee ),이혜란 ( H R Lee ),조영주 ( Y J Cho ) 대한임상검사과학회 1991 대한임상검사과학회지(KJCLS) Vol.23 No.1
Colorless nitro blue tetrazolium (N. B. T.) is reduced to a water-insoluble formazan which can easily be recognized as a deep blue deposit in cytoplasm. Although the mechanism of reduction of N. B. T. to form formazan in phagocytic neutrophils is uncertain. Park et al. reported that the number of meutrophils reducing N . B. T. dye invitro was significantly elevated in patients with acute systemic bacteria infection. Park also introduced a simple technique testing intrinsic defect of neutrophils to phagocytize and kill bacteria. When N. B. T. values are not increased in the presenee of acute bacterial infection by observing significant rise in N. B. T. positive neutrophils when Escherichia coli endotoxin is added in vitro. Chronic granulomatous disease (C. G. D.) results from a failure of patients phagocytic cells to kill ingested bacteria. The result``s of theN .B. T test in C.G.D. patients was false negative. So the present study was performed to stimulated N. B. T. test by endotoxin. The result``s of the S-N .B. T. test in C.G.D. patients and his father and his mother and his brother and health person are as followings : 1. The percentage of N . B. T. positive neutrophils was 0% in C. G. D. patients. 2. The percentage of N. B. T. positive neutrophils was 100% in his father, his brother, healthy person (control) 3. The percentage of N . B. T. positive neutrophils was 60% in his mother. The S-N. B. T. test would be diagnostic value in patients suspected of having C. G. D. which can not be killed bacteria by neutrophils.
원저(原著) : 백혈구의 Congenital Pelger-Huet Anomaly 2예
이귀순 ( Kuy Soon Lee ) 대한임상병리사협회 1994 임상혈액검사학회 발표자료집 Vol.1 No.1
Tho Pelger-Huet anomaly is a hereditary abnormality of granulocytes characterized by failure of nuclear segmentation. Recently the author experienced two cases of congenital Pelger Huet anomaly on routine hematologic examination in a 2-year-old girl and a 9-year-old boy. Her mother revealed Pelger-Huet anomaly in her family and his mother, sister reveals Pelger-Huet anomaly in his family, without specific symptoms. So the author report two cases with brief review of literature.
자동혈액응고 기가에서 PT, APTT 의 측정결과 비교분석 -< Fibrintimer and Electra-800>
이귀순 ( K S Lee ),박미영 ( M Y Park ),이혜란 ( H R Lee ),조영주 ( Y J Cbo ),정은경 ( E K Jung ),최종태 ( J T Choi ) 대한임상검사과학회 1992 대한임상검사과학회지(KJCLS) Vol.24 No.1
The Prothrombin time(P.T) test and activated partial thromboplastin time(APTT) test are commonly used for screening coagulation disorders and monitoring of anticoagulant therapy. We compared day to day reproducibility and normal range and coefficient of correlation of Fibrintimer and Electra-800 in PT. APTT. The results are : 1. Day-to-day reproducibility of PT and APTT expressed C.V. are 4.02%, 6.23% in Fibrintimer and 2.26%, 4.37% in Electra-800, which show good day to day reproducibility(P > 0.05). 2. The normal range of PT are 9.7 sec~ 13.3 sec in Fibrintimer and 10.1 ~ 13.3 sec, in ElectraBOO. The normal range of APTT are 26.8 sec ~34.2 sec in Fibrintimer and 25.3 sec~33. 5 sec in Electra-·800. 3. A coefficient of correlation of PT & APTT is 0.99 and 0.91 respectively between the Fibrintimer & Electra-800 which show high degree of correlation.
창의적·도전적 융합연구 생태계 구축을 위한 기초융합연구 지원체계 수립에 관한 연구
박귀순(Kwisun Park),신숙경(Suk Kyung Shin),송영동(Young Dong Song),이성종(Sung Jong Lee),이은규(Eunkyu Lee),차은종(Eun Jong Cha) 한국콘텐츠학회 2013 한국콘텐츠학회논문지 Vol.13 No.12
한국연구재단은 이공분야와 인문사회분야 간 통합 연구를 포함한 융합연구 생태계 구축으로 창의적이고 도전적인 연구를 중점적으로 지원하고자 한다. 이에 기초연구사업의 융합연구를 활성화하고 실질적인 융합연구를 발굴하기 위한 전략을 도출하고 창의적·도전적 융합연구 지원체계 구축을 골자로 하는 ‘융합연구사업추진체계’를 수립하였다. 사업추진체계는 연구분야 중심의 지원분야 재설정, 문제중심융합 신설, 신청자격 확대, ‘융합연구 우수성 평가’ 신설, 최소 융합성 지표 및 가이드라인 도출로 구성되었다. 동 사업추진체계 적용 전 약 38%였던 복수 연구분야분류 지정 경향이 적용 후 98% 이상으로 급증하여 거시적 분야분류 간 융합연구 지원이라는 근본적인 목적을 달성할 수 있는 가능성을 높였다. 선정여부와 융합연구 평가프로세스 간 회귀분석 및 피어슨 상관 분석 결과에 근거하여 평가 단계별 배점제에서 다음 단계 추천 방식으로 평가프로세스를 개선하였다. 또한 연구계획서 양식, 분야 지정 방식 개선안을 도출하여 2013년에 확대적용하였다. National Research Foundation of Korea (NRF) provides underpinning to boost international competitiveness in convergence research including research amalgamating Science and Engineering with Humanities and Social Sciences. Division of Electrical Engineering, Information Sciences and Convergence Research recategorized a scientific and engineering array of convergence research in basic sciences and reformed a Convergence Research Support Framework in 2012. The test case was thoroughly analyzed and reviewed for successful application in the 2013 mid-career researcher program. The core of convergence research-specific review process is ‘Suitability Review’ that is performed by the ‘Suitability Review Committee for Convergence Research’ and ‘Merit Review’ that is conducted as a conventional peer review. As a good result of the pilot program, prior allocation of budget for convergence research was decided to the 2013 Core Research Program and the modified convergence Research Support Framework was extensively applied in the ‘2013 Implementation Plan for Basic Research Program in Science and Engineering.’