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Bacillus subtilus Complex BC1212에서 생산된 Surfactin의 시험관내 향균활성 및 토끼에서 일차피부자극시험
황미현(Mi-Hyun Hwang),윤효인(Hyo-In Yun),임종환(Jong-Hwan Lim),김길수(Kil-Soo Kim),이만휘(Man-hee Rhee),김남우(Nam-Woo Kim),김종춘(Jong-Choon Kim),박승춘(Seung-Chun Park) 한국독성학회 2005 Toxicological Research Vol.21 No.1
The present study was carried out to investigate the antibacterial activity against Staphylococcus aureus with antibiotic-resistance in vitro and the skin irritation in rabbits with surfactin produced by Bacillus subtilus Complex BC1212. The antibacterial activities of selected antimicrobial agents (surfactin, amoxacillin, colistin, norfloxacin and streptomycin) were evaluated by using the broth microdilution method. As the results, the minimum inhibitory concentration (MIC) of the surfactin was less than 15.6 μg/ml. In the skin irritation test, two out of 4 rabbits showed very slight edema at 24 h after the administration of surfactin, and then recovered at 72 h. The change of body weight was normal during the skin irritation test. The primary irritation index in accordance with the Draize evaluation of topical reaction was calculated to be "0.125", which meant not irritating. Based on these results, it could be concluded that the test agent, surfactin, was a non-irritant. We could also think that the surfactin may be useful for the treatment of S. aureus infections such as bovine mastitis.