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Eicosanoid 유도체가 흰쥐 혈압 변화에 미치는 영향
윤재순(Jae S . Yun),윤연숙(Yeon S . Yun),신정희(Jeung Hee Shin),최현진(Hyun J Choi),최진아(Jin A Choi) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2
Arachidonic acid (AA, C20 : 4, ω-6) and eicosapentanoic acid (EPA,C20: 5, ω-3), which are polyunsaturated fatty acids forming eicosanoids, were tested for their effects on blood pressure in Wistar rats and SHR. AA is the most important precursor for the biosynthesis of eicosanoids which include the prostaglandins, prostacyclin (PGI₂), thromboxane A₂ (TXA₂) and the leukotriens. TXA₂ is a potent vasoconstrictor and a powerful inducer of platelet aggregation causing myocardial infarction and hypertention. In contrast, PGI₂ induces vasodilation and inhibits platelet aggregation. In this study, AA markedly increased blood pressure, but its effect was antagonized by both EPA, a structural analog of AA, and dazmegrel, a TX synthetase inhibitor. Also, AA enhanced the antihypertensive effects of hydralazine and captopril, and EPA reduced TXA₂ production. These results indicate that the hypotensive effects of EPA might be closely related to the decrease in TXA-2 biosynthesis due to competitive inhibition by structural similarity of the EPA to the AA, the precursor of TXA₂.
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Eicosanoids가 뇌허혈증 흰쥐의 에너지대사 및 Ca++ 이동에 미치는 영향
한현정(Hyun J. Han),이용규(Youg K. Lee),신정희(Jeung H. Shin),윤재순(Jae S. Yun) 대한약학회 1994 약학회지 Vol.38 No.1
We studied the effect of eicosanoids on the content of energy metabolites and the intrasynaptosomal Ca++([Ca++]i) concentration in cerebral ischemic rats. An ischemic model was made by bilateral carotid artery ligation (BCAL) and by incubation of synaptosomes under aglycemic and N2 gas bubbling condition. The content of ATP, creatine phosphate and glucose decreased at 15minutes after BCAL while that of lactate increased in male Wistar rats. Oral administration of EPA(100mg/ml/Kg/day) or DHA(16mg/ml/Kg/day) for 6 weeks improved both the decreases and the increase of the cerebral energy metabolites. In addition, the increase of [Ca++]i under BACL was suppressed by EPA or DHA treatment. When the both Wistar rats and SHR were administered orally with EPA or DHA for 6 weeks, the effect on the increase of [Ca++]i under ischemia by N2 gas bubbling were protected. From these results, it may be that EPA or DHA treatment were greatly contributed to preservation of ischemic cerebral energy metabolism and Ca++ concentration.
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Eicosanoid 유도체가 흰쥐 혈압 변화에 미치는 영향
윤재순,윤연숙,신정희,최현진,최진아 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5
Arachidonic acid (AA, C20:4, w-6) and eicosapentanoic acid (EPA,C20:5, w-3), which are polyunsaturated fatty acids forming eicosanoids, were tested for their effects on blood pressure in Wistar rats and SHR. AA is the most important precursor for the biosynthesis of eicosanoids which include the prostaglandins, prostacyclin (PGI_2), thromboxane A_2 (TXA_2) and the leukotriens. TXA_2 is a potent vasoconstrictor and a powerful inducer of platelet aggregation causing myocardial infarction and hypertention. In contrast, PGI_2 induces vasodilation and inhibits platelet aggregation. In this study, AA markedly increased blood pressure, but its effect was antagonized by both EPA a structural analog of AA, and dazmegrel, a TX synthetase inhibitor. Also, AA enhanced the antihypertensive effects of hydralazine and captopril, and EPA reduced TXA_2 production. These results indicate that the hypotensive effects of EPA might be closely related to the decrease in TXA_2 biosynthesis due to competitive inhibition by structural similarity of the EPA to the AA, the precursor of TXA_2.
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Eicosanoids가 뇌허혈증 흰쥐의 에너지대사 및 Ca^++이동에 미치는 영향
한현정,이용규,신정희,윤재순 梨花女子大學校 藥學硏究所 1994 藥學硏究論文集 Vol.- No.4
We studied the effect of eicosanoids on the content of energy metabolites and the intrasynaptosomal Ca^++ (〔Ca^++〕_1) concentration in cerebral ischemic rats. An ischemic model was made by bilateral carotid artery ligation (BCAL) and by incubation of synaptosomes under aglycemic and N_2 gas bubbling condition. The content of ATP, creatine phosphate and glucose decreased at 15 minutes after BCAL while that of lactate increased in male Wistar rats. Oral administration of EPA(100 ㎎/㎖/㎏/day) or DHA(16 ㎎/㎖/㎏/day) for 6 weeks improved both the decreases and the increase of the cerebral energy metabolites. In addition, the increase of 〔Ca^++〕_1 under BACL was suppressed by EPA or DHA treatment. When the both Wistar rats and SHR were administered orally with EPA or DHA for 6 weeks, the effect on the increase of 〔Ca^++〕_1 under ischemia by N_2 gas bubbling were protected. From these results, it may be that EPA or DHA treatment were greatly contributed to preservation of ischemic cerebral energy metabolism and Ca^++ concentration.
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