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박세진, 채희복, 한정호, 윤순만, 박선미, 윤세진 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1
자가면역 간염의 정확한 진단을 위해서는 먼저 특징적인 자가면역 간염의 임상 양상과 검사 소견, 그리고 다른 원인에 의한 만성간염의 가능성을 배제할 수 있어야 한다. 본 연구는 2009년에서 2010 년의 자가면역 간염 증례 3례를 살펴 보았다. 아울러 진단 점수표를 이용하여 자가면역성 간염 진단의 객관성을 검토해 보고자 하였다. 본 증례보고는 2009년에서 2010년까지 본 병원에서 자가면역 간염 으로 진단되었던 세 증례에 관한 연구이며, 주로 진단과 치료에 대한 반응을 중심으로 기술하였다. 혈 액을 이용한 간기능 검사는 치료 전과 치료하는 기간 동안 내내 지속적으로 매 1주일마다 시행되었다. 3명의 환자들은 모두 여성으로 평균 나이는 53.7세(48~64)였다. 세 명의 환자 모두에서 표준 치료 요법에 좋은 반응을 나타내었다. 간조직 검사는 2명의 환자에서 시행되었으며 자가면역간염에 부합하 는 병리소견을 나타내었다. 환자들은 prednisolone 단독요법이나 prednisolone과 azathioprine 병 합요법 치료를 받았다. 치료시작 시점으로부터 치료 종료에까지 걸린 시간은 한 달에서 두 달 사이에 분포하였다. 재발은 한 명의 환자에서 치료 종결 후 5개월 째 관찰되었다. 결론적으로 자가면역 간염 환자 세 명은 모두 전형적인 임상양상과 간기능 검사 소견을 나타내었다. 면역 억제 치료제를 투여하였 을 때의 치료반응은 매우 효과적이었으며, 대체로 한 달에서 두 달 사이에 신속하게 나타났다. 재발은 한 명의 환자에서만 관찰되었다.
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김중환,윤세진,전장원 대한피부과학회 1981 大韓皮膚科學會誌 Vol.19 No.3
The nevus spilus, also called speckled lentiginous nevus, presents itself as a patch of melanization dotted by smaller macules of darker color, frequently occuring on the trunk, and in some respect, resembeing the cafe au lait of von Recklinghausens disease and Albrights syndrome. We present clinical and histopathologic observation made on 14 patients, 13 male and 1 female, who agreed to go through a biopsy, during 5 years period from 1975 to 1980. The age at the visit ranged from 11 years to 61, with a mean of 22. 4. The location of lesions were shouIder (in 5 cases), neck (in 2), back (in 2), trunk (in 4),arm (in 1), and buttock (in 1). The epidermal changes consist of hypererkatosis (in 7), acanthosis (in 6), elongation of rete ridge and papillomatosis (in 9), basilar hypermelanosis (in 14), and nevus cell nests(in 3). The dermal changes consists of mild perivascular lymphoid and histiocytic cellular infiltrations (in 11), chromatophores (in 8) and dilated blood vessels (in 6). It is suggested that nevus spilus should be considered as a giant lentigo, a neoplasia of epictermal melanocytes, where junctional nevus is to develop.
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김중환,윤세진 대한피부과학회 1980 大韓皮膚科學會誌 Vol.18 No.5
Fundamental pathologic cianges of secondary syphilid are said to be swelling and proliferation of endothelials and a predominantly parivascular infiltrates composed chiefly of lymphoid cells and plasma cells. But recentIy this theory has heen challenged. We present bistologic observation made on 10 patients who agreed to go through a biopsy, during 2 years period. from 1975 to l977. Male to female ratio was 9: 1 The age of patient ranged from 20 to 33, with a mean of 26. 8. The duration of lesion before the visit to the department ranged frorn 6 weeks to 20 weeks, with a mean of 11.9. The lesions in 2 were classified as macule, 3 as papule (1 as moist papule), and 5 as papulo-squamous lesions. The VDRL titer was higher in papular type. Dark fieId examination was performed on all patient and 6 showed positive result. The edidermal changes consist of hyperkeratosis (in 6 cases), parakeratosis (in 5), acanthosis (in 6), elongation of rete ridges (in 8) and exocytosis (in 3). The dermis showed mild to severe perivascular infiltration consist chiefly of lymphoid cells and histiocytic cells (in 10), plama cells (in 7), eosinophils (in 4), neutrophils (in 2), chromatophores (in 4), extra vasation of RBC (in 5), and dilated bload vessels endothelial swellings (in 8). Of particular interest was the finding that plasma cell infiltration is more pronounced at the lower portion of dermal infiltrate and in 3 cases plasma cell infiltration was totally absent. Vascular changes were seen in 8 cases.
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대상포진 (帶狀疱疹) 에 동반된 동통의 경피전기자극 ( Transcutaneous nerve stimulation , TNS ) 에 의한 치료
김중환,윤세진,변장호 대한피부과학회 1981 大韓皮膚科學會誌 Vol.19 No.1
The gate control theory was proposed by Melzack & Wall in 1965. This theory implies that selective stimulation of cutaneous afferent fibers of large diameter inhibits pain. Transcutaneous electrical stimulation(TNS) is a practical employment of this concept. TNS was used on 14 herpes zoster patients to relieve associated pain. Good effeet was obtained in 13 patients. They experienced relief of their pain for 1-4 hours after 20 minutes of application. TNS has many advantages over analgesic drugs in the control of pain in herpes zoster.
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김중환,윤세진 대한피부과학회 1980 大韓皮膚科學會誌 Vol.18 No.5
Lichen nitidus is a comparatively rare, asymptomatic, chronic disease displaying small, sharpIy defined, fresh colored papules usually localized on the penis, arms and the abdomen. Waisman found immunoglobulin at the dermo-epidermaI junction in lichen planus, but not in lichen nitidus. This settled the argument whether lichen nitidus is a variant of lichen planus. A 11 year old healthy girI was brought to the clinic because of many flesh colored discrete papules on the cubital fossae and the anterior chest. The papules are skin colored. pinhead sized, round, and flat-topped The lesions appeared first at the age of 8 on the antecubital folds and in the following years, increased in number and extended slowly to the upper arms and the anteior chest.
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