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신이식후 당뇨병의 특성 및 유발인자에 대한 임상적 분석
윤선애(Sun Ae Yoon),김현웅(Hyun Eung Kim),김용수(Yong Soo Kim),윤영석(Young Suk Yoon),방병기(Byung Kee Bang),김희제(Hee Je Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.1
N/A In order to assess the clinical characteristics and risk factors of post-transplant diabetes, the courses of 437 renal transplants (former nondiabetics), who received transplants between March, 1969 and May, 1990 in Catholic University Medical College, were reviewed retrospectively. 37 (8.5%) of 437 renal transplants manifested posttransplant diabetes. This incidence was much higher than usual incidence of diabetes (3.5%) in Korean population (p=0.000). The hyperglycemia was found in postoperative 1 to 108 months (median; 3 months), and followed up 3 to 103 months (37±26 months). We simultaneously tested the effects of age, sex, type of immunosuppressants and donor relationship on posttransplant diabetes statistically and found female prevalence (p=0.013). Gene frequency of HLA Bw62 antigen in posttransplant diabetics (21.6%) was higher than that (8.5%) in general population (p=0.004). The actuarial patient and graft survivals in post-transplant diabetics were greater than those in Azathio-prine and prednisolone treated patients, and similar to those in Cylosporine A and prednisolone treated patients. We conclude that posttransplant diabetes is of greater prevalence in female and renal transplants expressing HLA Bw62 antigen, and does not ameliorate the patient and graft survivals after renal transplantation.
중증 급성 신부전의 원인의 되었던 급성 국소성 세균성 신염
윤정민 ( Jung Min Yoon ),윤선애 ( Sun Ae Yoon ),김영옥 ( Young Ok Kim ),김미정 ( Mi Jung Kim ),차현민 ( Hyun Min Cha ),곽승기 ( Sung Ki Kwak ),김해림 ( Hae Rim Kim ),최영진 ( Young Jin Choi ),방병기 ( Byung Kee Bang ) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.6
Urinary tract infection is one of the causes of acute renal failure. But it has been reported rarely, so we must consider another etiologies before diagnoses. Abdominal ultrasonogram is a good non-invasive technique for radiologic diagnosis or for differential diagnosis, but it`s possible that tiny abscesses and small lesions of focal bacterial nephritis might be missed CT is the best radiologic method to diagnose renal lesion, especially acute bacterial nephritis. Nevertheless, CT has several problems, including contrast-induced nephropathy, exposure to radiation. We experienced a severe form of anuric acuric acute renal failure secondary to acute bacterial nephritis due to E, coli infection, The patient`s renal lession was not visualized on the ultrasonogram and his uremic symptom was severe. So we decided to do a kidney biopsy to find another possible cause of acute renal failure. The renal biopsy finding showed acute bacterial nephritis, and abdominal CT reconfirmed it. His serum creatinine increased to a maximum 8.5 ㎎/dL, but decreased to 1.24 ㎎/dL through continuous antibiotic therapy. We emphasize that urinary tract infection is not a rare cause of acute renal failure any more, and that positive diagnositic approaches, including kidney biopsy, are important for accurate and early diagnosis.
윤나리 ( Na Ri Yoon ),최정란 ( Joung Ran Choi ),심병주 ( Byung Joo Shim ),강현희 ( Hyun Hee Kang ),김영수 ( Young Soo Kim ),윤선애 ( Sun Ae Yoon ),김영주 ( Young Joo Kim ),박정욱 ( Jung Wook Park ),김영옥 ( Young Ok Kim ) 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.5
Uremic patients undergoing hemodialysis (HD) therapy are prone to develop encephalopathy, but the cause is often unclear. Clinical signs of encephalopathy in the uremic patient often overlap with several other affections causing neurological disorders. Chorea or hemichorea occurs very rare, when basal ganglia are injured in HD patients. We hereby report a case of hemichorea of unknown cause in a hemodialysis patients. A 57-year-old diabetic HD patient was presented with sudden onset of right hemi-chorea. We could not find causes of hemichorea such as hyperglycemia, hepatic failure, drug, hyponatremia, and thiamine deficiency. T1-weighted MRI demonstrated hyperintense lesion limited to the left basal ganglion. Hemichorea disappeared completely 6 months after the onset with support care. (Korean J Nephrol 2006;25(5):847-850)
증례 : Thiazide에 의한 저칼륨혈증성 횡문근융해증 2예
신승환 ( Seung Hwan Shin ),손덕승 ( Der Sheng Sun ),김길선 ( Guil Sun Kim ),김영수 ( Young Soo Kim ),윤선애 ( Sun Ae Yoon ),장윤식 ( Yoon Sik Chang ),김영옥 ( Young Ok Kim ) 대한내과학회 2007 대한내과학회지 Vol.72 No.1
Hypokalemia is a common metabolic cause of rhabdomyolysis. Although treatment with thiazide causes hypokalemia frequently, hypokalemic rhabdomyolysis after administration with thiazide is very rare. Here we report two cases of hypokalemic rhabdomyolysis due to thiazide treatment. A 50-year-old woman who had been treated with thiazide for hypertension was admitted due to quadriplegia. The patient had a potassium level of 1.5 mEq/L, a creatinine phosphokinase (CPK) level of 21,346 IU/L, and a lactic dehydrogenase level (LDH) of 2,389 IU/L. An 80-year-old man who had been treated with thiazide for hypertension was admitted due to generalized weakness. His potassium level was 1.9 mEq/L, CPK was 29,000 IU/L, and LDH was 2,393 IU/L. There were no any other causes of rhabdomyolysis except hypokalemia due to thiazide treatment for both patients. With adequate hydration and potassium replacement, hypokalemic rhabdomyolysis recovered completely without sequele. (Korean J Med 72:100-104, 2007)
과제 지향 보상을 활용한 협동학습에서 소집단 활동 점검 과정이 중학교 과학 수업에 미치는 효과
노태희 ( Tae Hee Noh ),김경순 ( Kyung Sun Kim ),윤선애 ( Seon Ae Yoon ),한재영 ( Jae Young Han ) 한국과학교육학회 2004 한국과학교육학회지 Vol.24 No.5
This study investigated the effects of group processing in cooperative learning using task-oriented reward on students` science achievement, science learning motivation, and attitude toward science instruction. Eighth graders (N=58) selected from a middle school in Seoul, were randomly assigned to either the treatment or comparison group, and taught on the `Separation of Mixture` over 8 class hours. The treatment group received cooperative learning using task-oriented reward containing group processing (GCL), while the comparison group received cooperative learning using task-oriented reward without group processing (CL). Significant interactions between the instruction and prior achievement level were found in the achievement and the attitude toward science instruction. High-level students in the GCL group performed better than those in the CL group, while low-level students in the CL group performed better than their counterparts.