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혈청 크레아티닌이 정상인 증식성 루푸스 신염의 경정맥 Cyclophosphamide 강압 요법 효과
김성일 ( Sung Il Kim ),유완희 ( Wan Hee Yoo ),이신석 ( Shin Seok Lee ),김완욱 ( Wan Wuk Kim ),민준기 ( Jun Ki Min ),이상헌 ( Sang Heon Lee ),박성환 ( Sung Hwan Park ),홍연식 ( Yeon Sik Hong ),조철수 ( Chul Soo Cho ),김호연 ( Ho Yo 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.2
Objective: To evaluate the efficacy of intravenous cyclophosphamide pulse therapy(IVC) in proliferative lupus nephritis (PLN) with normal serum creatinine. Methods: We retrospectively reviewed 53 PLN patients treated with IVC more than 6 times from 1992 to 1997. The patients were classified into the alternative and the initial. In the former, IVC was started after failed remission with steroid or steroid and oral immunosuppressive drug; in the latter, IVC was started as initial treatment. Remission was endpoint of study and defined as all of the followings should be maintained for more than 6 months, 1) 24-hour urine protein less than 1g, 2) normal serum creatinine, 3) less than 5 RBC in high power field microscopy and no granular and RBC cast in urine. We compared remission rate and frequency of complications associated with IVC between the initial and alternative by chi-square test and analyzed the variables of remission including methodological; initial or alternative, clinical; age, onset age of systemic lupus erythematous (SLE) and lupus nephritis (LN), duration of SLE and LN, laboratory; serum concentration of creatinine, C3, C4, albumin, anti ds-DNA Ab. titers and 24 hour urine proteins and pathological; activity and chronicity index, multivariatly. Results: All 53 patients (22 initial, 31 alternative) had normal serum creatinine at start of IVC, treated with 9.7±2.3 times of IVC and followed up during 37.2±15.4 months. Thirty-four patients (64%) had remission (18 of the initial and 16 of the alternative). The remission rate of the initial was higher (82% vs 52%, p=0.04 by chi-square test) than the alternative, but frequency of complications was not different. In multivariate analysis, any other variables; including methodological, clinical, laboratory and pathological, did not influenced on remission significantly. Conslusions: IVC is effective in PLN with normal serum creatinine as initial treatments and our results suggest that IVC may be chosen as an alternative therapy in PLN patients who failed remission with steroid or steroid and oral immunosuppressive drug.
박종현 ( Jong Hyun Park ),박성환 ( Sung Hwan Park ),김백선 ( Paek Sun Kim ),이준욱 ( Joon Wook Lee ),유완희 ( Wan Hee Yoo ),주영실 ( Yeong Shil Joo ),이신석 ( Shin Seok Lee ),김완욱 ( Wan Uk Kim ),민준기 ( Jun Ki Min ),홍연식 ( Ye 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.3
Dermatomyositis is a clinical entity characterized by a distinctive cutaneous rash and inflammatory myopathy. In this disorder, the pneumomediastinum is quite a rare complication and is assumed to result from air leakage due to vasculitis, lung fibrosis or rarely after bronchoscopic lung biopsy and pulmonary function test. We describe patient with dermatomyositis who developed pneumomediastinum, pneumothorax and massive subcutaneous emphysema after pulmonary function test. She died due to respiratory failure. We think that careful observation is required in performing PFT in dermatomyositis patients with presumed interstitial lung diseases.
원발성 갑상선 기능 저하증 환자의 아포지단백 E(Apo E) 유전자 다형성
김남수,유완희,박태선,백홍선 의과학연구소 1999 全北醫大論文集 Vol.23 No.1
The frequeney of fasting hyperlipidemia increases in most hypothyroid patients. However, the cause and mechanism of hyperlipidemia in primary hypothyroidism is not known. In this study, the genetic factor of the hyperlipidemia in primary hypothyroidism patients by the apolipoprotein E(Apo E) gene polymorphism was investigated. Apo E gene polymorphism of the 51 primary hypothyroidism patients and healthy control persons was analysed by modified Amplification Refractory Mutation System(ARMS) technique. Concurrently, total cholesterol, triglyceride, HDL cholesterol and total T₃, free T₄, TSH were measured by standard laboratory methods. The apo E gene allele and phenotype frequency in hypothyroid patients were similiar with those in healthy control person. The ap E3 allele frequency of hypercholesterolemic group was slightly decreased and the apo E4 allele frequency showed the increasing tendency. The apo E3/3 phenotype of hypercholesterolemic group was decreased and apo E2/4 and apo E3/4 phenotype of hypercholesterolemic group was increased. In conclusion, there was no difference in Apo E polymorphism between hypothyroid patiesnts and healthy control. Apo E polymorphism seemed to be associated with hypercholesterolemia in primary hypothyroidism. Further investigation is needed for the another cnadidate genes and apolipoprotein analysis in primary hypothyroidism and environmental factors. (Key Word(s) : Apo E polymorphism, Hypothyroidism, Hypercholesterolemia)