만5세 일반아동과 기능적 조음음운장애아동의 음운처리능력과 읽기 능력 비교

유민아 ( Yu Min-Ah ),임영심 ( Lim Young-sim ),김은나 ( Kim Eun-na ) 한국유아교육학회 2021 유아교육연구 Vol.41 No.6

기능적 조음음운장애아동과 일반아동에 비해 음운인식능력과 읽기 능력이 주장은 있으나, 음운적 작업기억과 음운적 정보회상을 포함한 음운처리 능력 전체와 읽기능력간의 상관관계를 살펴보는 선행 연구는 부족하다. 따라서 본 연구에서는 만 5세 일반아동과 기능적 조음음운장애 아동의 음운처리능력과 읽기 능력을 살펴보고 각 집단에서 음운처리능력 하위영역 간의 상관관계를 살펴보고자 하였다. 본 연구의 대상은 만 5세 기능적 조음음운장애 아동 20명과 일반 아동 20명으로 총 40명으로 선정하였다. 음운인식 능력은 음절 수준으로 측정하였으며, 음운적 작업기억 능력은 숫자 회상 검사와 무의미 단어 회상 검사로 측정하였고, 음운적 정보회상 능력은 사물 빠르게 말하기 과제와 색깔 빠르게 말하기 과제를 사용하였다. 읽기 능력 측정을 위해서 고빈도, 저빈도, 무의미로 나눠 단어재인과 읽기 유창성 능력을 측정하였다. 연구결과 집단간 음운처리 능력 차이에서 일반아동이 기능적 조음음운장애 아동보다 음운처리능력과 단어 인지능력에서 높게 나타났다. 일반아동과 기능적 조음음운장애아동은 음운인식능력은 단어인지와 읽기 유창성 모두 상관관계가 나타났다. 그러나 일반아동은 음운적정보회상능력이 단어인지 능력과 상관관계를 보였고, 기능적 조음음운장애아동 음운적 정보회상능력이 음운인식과 음운적작업기억능력과 상관관계를 나타내었다는 점에서 차이가 있다. 이는 기능적 조음음운장애 아동은 각각의 음운처리가 일반아동에 비해 빠르게 잘 이뤄지지 않다는 것을 나타낸다. 따라서, 기능적 조음음운장애아동은 읽기 단계 전 말소리 훈련과 같은 음운처리 훈련이 필수적으로 이뤄져야 함을 시사한다. This research was performed to compare the phonological processing and reading ability characteristics between the children with and without functional articulatory and phonological disorders. The two groups’ differences were observed in terms of phonological processing and reading abilities, along with the correlation and impacts present between the two characteristics. The research was conducted to 20 children without disabilities and 20 children with functional articulatory and phonological disorders, both in age 5. The summary of result is as follows. First, the children without disabilities in age 5 showed better phonological processing ability than the children with functional articulatory and phonological disorders did. Second, the children without disabilities in age 5 presented greater reading ability than the children with functional articulatory and phonological disorders did. Third, the difference in the reading ability between children with and without functional articulatory and phonological disorders in age 5 was only found in word recognition. The phonological awareness of children with and without functional articulatory and phonological disorders affected both their abilities of word recognition and reading for fluency. Furthermore, such a result was more explainable in the case of children with functional articulatory and phonological disorders. In both groups, the greater word recognition ability was correlated with higher reading for fluency ability. In the case of children without disabilities, their phonological awareness was only correlated with their reading ability. On the other hand, the phonological awareness of children with functional articulatory and phonological disorders had a positive relationship with their phonological information retrieval, word recognition, and reading for fluency.

아동이 지각한 어머니의 인성지향적 언어통제와 아동의 또래관계 간의 관계에서 공감능력의 매개효과

홍유민(Yu min Hong),최진아(Jin ah Choi) 한국아동학회 2018 아동학회지 Vol.39 No.2

Objective: This study aims to verify the mediating roles of empathy on the relationship between mothers’ personal-oriented verbal control style as perceived by children and children’s peer relationships. Methods: The participants were 291 students (Grade 5 and 6) from six elementary schools in Gwangju/Jeonnam. Results: First, positive correlations were shown between the mothers personal-oriented verbal control style, empathy, and peer relationships. In addition, empathy was positively correlated with peer relationships. Second, the mothers personal-oriented verbal control style influences peer relationships through empathy as a mediating variable. Conclusion: Empathy completely mediates the relationship between mothers’ personal-oriented verbal control style as perceived by children and the children’s peer relationships. Such results could be used as basic data to enhance childrens empathy and conduct follow-up research on variables related to elementary schoolers’ peer relationships; they can also be helpful for the counseling and development of programs for the formation of positive peer relationships.

DSS로 유도된 마우스 대장염 모델에서 꽃새우 추출물의 항염증 효능

최유민(Yu Min Choi),박지선(Ji Sun Park),강정은(Jeong Eun Kang),최수철(Soo Cheol Choi),이성훈(Sung Hoon Lee),이인아(In-Ah Lee) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.9

꽃새우는 우리나라 서 · 남해안에 분포하며 철분, 칼슘, 타우린 등 다양한 영양소가 들어있다. 본 연구에서는 꽃새우 추출물을 이용하여 LPS로 염증이 유도된 RAW 264.7 세포와 DSS로 염증이 유도된 ICR mouse 모델에서 항염증 효과를 실험하였다. RAW 264.7 세포와 마우스의 대장 조직을 이용해 RT-PCR을 진행하였을 때 꽃새우 추출물 투여는 염증성 사이토카인인 IL-6, TNF-α, IL-1β와 염증매개 물질인 iNOS, COX-2의 발현이 감소하였다. 또한, 대장 조직 내 단백질 발현을 유의하게 감소시켰으며, 대장 조직 손상을 개선하였다. 이와 같은 연구 결과를 보아 꽃새우 추출물은 in vivo와 in vitro에서 염증성 사이토카인을 억제하는 효과가 있음을 제시하고 있다. 꽃새우가 염증성 장 질환 치료 및 예방에 효과적인 물질로서의 가치를 입증하기 위해서는 염증 반응에 영향을 미치는 성분 확인이 필요하다고 사료된다. Trachysalambria curvirostris is a crustacean found near the southwest coast of Korea which contains various nutrients such as iron, calcium, taurine, and chitosan. In particular, chitosan has anti-inflammatory, antibacterial, anticancer, and antioxidant effects. The purpose of this study was to evaluate the anti-inflammatory effect of the extract of Trachysalambria curvirostris on inflammatory bowel disease (IBD). Inflammatory factors (COX-2, IL-1β, IL-6, iNOS, TNF-α) in cells and colon tissue induced by lipopolysaccharide (LPS) and dextran sulfate sodium (DSS) were confirmed using RT-PCR. The generation of cytokines (IL-6, TNF-α) in the colon tissue protein of ICR mice caused by DSS was measured by ELISA. Compared to the LPS and DSS groups, the expression level of inflammatory cytokines showed a reduction in the group treated with the Trachysalambria curvirostris extract. Similarly, the ELISA results showed that the expression level of inflammatory cytokine decreased compared to the DSS group. As a result of H&E staining using mouse colon tissue, it was possible to observe a lower invasion of inflammatory cells in the Trachysalambria curvirostris treated group than in the DSS group. It is necessary to conduct additional research on the exact mechanism of reaction to identify the active components in the Trachysalambria curvirostris extract, and to prove the value of the Trachysalambria curvirostris for IBD prevention and treatment.

저분자량 헤파린 사용에 있어 신기능 정도에 따른 출혈경향 연구

송은주 ( Eun Ju Song ),이승엽 ( Seung Yup Lee ),정유민 ( Yu Min Jung ),노경우 ( Kyung Woo Nho ),성수아 ( Su Ah Sung ),황영환 ( Young Hwan Hwang ),이소영 ( So Young Lee ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.2

Purpose: Low molecular weight heparin (LMWH) is safe and effective in the treatment of acute coronary syndrome (ACS) and venous thromboembolism. Compared with unfractionated heparin (UFH), it is known to have less bleeding tendency in the general population. However, it is not certain whether bleeding complications are decreased by LMWH in patients with renal failure. We postulated that the use of LMWH may lead to increase in bleeding tendency in patients with renal dysfunction. Methods: We conducted a retrospective study in 486 hospitalized patients who were diagnosed as cerebral infarction or ACS, and treated with enoxaparin or nadroparin from January 2008 to December 2009. Bleeding complications were compared in 3 groups according to estimated glomerular filtration rate (GFR 60, 30-59, and <30 mL/min/1.73m ≥ 2). Age, hypertension (HTN), diabetes mellitus (DM), smoking and usage of antithrombotics were examined and the relationship of these variables with bleeding tendency was analyzed. Results: Compared with group I, the frequency of total bleeding complications increased in patients with group II (p=0.002) and III (p=0.005) regardless of adequate dose reduction. Multiple logistic regression analysis after adjustment for age, HTN, DM, and usage of antithrombotics revealed that decreased GFR groups [odds ratio (OR) of group II was 5.79 (95% confidence interval (CI), 1.23-29.97; p=0.042), OR of group III 5.92 (95% CI, 1.22-27.61; p=0.029)] and DM [OR of DM 7.88 (95% CI; 1.46-46.32, p=0.026)] were two independent factors which affect major bleeding. Conclusion: These findings suggest that renal insufficiency, even if it is mild, could affect major bleeding complications in the use of LMWH.