만삭 임신에서 Oxytocin 자극시 모체 및 태아제대혈청 Prolactin치의 변화에 관한 연구

원규숙,전선희,안정자,유한기,강신명 대한산부인과학회 1986 대한산부인과학회 학술대회 Vol.58 No.-

자궁내 발육지연 1 임신성 고혈압

원규숙,박은희,홍경희,안정자,강신명 대한산부인과학회 1984 대한산부인과학회 학술대회 Vol.53 No.-

만삭임신에 있어서 Oxytocin자극시 모체 및 태아 제대혈청 Prolactin치의 변화에 관한 연구

원규숙(GS Won),안정자(JJ Ahn),강신명(SM Kang) 대한산부인과학회 1987 Obstetrics & Gynecology Science Vol.30 No.11

1986년 1월부터 1986년 3월까지 이화대학병원에 입원한 합병증이 없는 무진통의 만삭 임부 41예에 대하여 oxytocin자극전 모체혈청 prolactin치와 oxytocin으로 15∼20분(11예), 25∼30분(11예), 35∼45분(6예) 및 50분(13예) 동안 규칙적인 자궁수축을 유발, 자극시킨 후 모체혈청 prolactin치를 측정하고 곧 제왕절개술로 분만하여 태아제대혈청 prolactin치를 측정하였다. 대조군으로 무진통의 만삭 임부 6예에 대하여 oxytocin자극없이 모체혈청 prolactin치를 측정하고 곧 제왕절개술로 분만하여 다음과 같은 결론을 얻었다. 1. Oxytocin자극후의 평균 모체혈청 prolactin치는 그 자극전의 평균치에 비하여 통계학적 차이는 없었으나, 자극 50분 후의 평균 모체혈청 prolactin치는 상승하는 경향이 있었다. Oxytocin자극후에 모체혈청 prolactin치가 증가한 예의 빈도는 그 자극 시간을 증가시킬수록 자극전에 비하여 점진적으로 더 증가하는 경향을 보였다. 2. Oxytocin자극후 제왕절개술로 분만된 태아의 평균제대혈청 prolactin치의 변화에 있어서 15∼20분간 및 25∼30분간 자극군에서 각각 273.8±24.7ng/ml, 248.0±25.4ng/ml으로 oxytocin자극없이 제왕절개분만된 태아의 평균 prolactin치(280.5±26.4ng/ml)에 비하여 거의 차이가 없었으나, 35∼45분간 및 50분간 자극군에서는 각각 339.0±47.7ng/ml, 339.1±44.6ng/ml로서 oxytocin자극없이 분만된 평균 제대혈청 prolactin치에 비하여 각각 20.9%가 증가되었다. 모체측 및 태아측 평균 혈청 prolactin치 비의 변화에 있어서 자극시간을 35분 또는 그 이상으로 증가시켰을 때에 태아측 평균 제대혈청 oxytocin치가 모측형성 평균 prolactin치에 비하여 더 증가하는 경향이 있었다(1:1.1:, 1:1.2). It is suggested that prolactin leads to accelerate surfactant formation in maturing fetal lungs. The purpose of this study was to evaluate the changes of prolactin levels in maternal and cord blood after oxytocin stimulation during term pregnancies. This study is based on the 47 cases of uncomplicated term pregnant women including 6 cases of control subject indicating elective cesarean section(no labor). A controlled intravenous oxytocin stimulation was tried in inducing 3 contractions per 10 minutes for a various short time period just before cesearean section to term pregnant women. Blood sample was taken from mothers before and after oxytocin stimulation and from fetal umbilical cord right after oxytocin stimulation and from fetal umbilical cord right after cesarean delivery. Serum prolactin was analyzed by solid-phase radioimmunoassay(Abbott laboratories, U.S.A.). The results were as follows: 1. The mean level of maternal serum prolactin after oxytocin stimulation showed no significant changes. Mean level of maternal serum prolactin after ocytocin stimulation for 50 minutes however tended to be increased. The incidence of increased maternal serum prolactin level after various time of oxytocin stimulation generally seemed to be increased compared with the level before stimulation. 2. The mean prolactin level of fetal cord serum after oxytocin stimulation followed by immediate cesarean delivery showed no statistical changes in the subjects stimulated for 15-25 minutes or 25-30 minutes. The mean prolactin levels of fetal cord serum after oxytocin stimulation for 35-45 minutes or 50 minutes subjects compared with non stimulated subjects were increased to 20.9% respectively(339.0+47.7 vs. 280.5+26.4ng/ml, 339.1+446 vs. 280.5+26.4ng/ml).

임신 주수별 신생아 출생체중 및 자간전증과의 비교 관찰

원규숙(GS Won),박은희(EH Park),강신명(SM Kang) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.7

이화여자대학교 의과대학 산부인과에서 1982년 1월 1일부터 12월 31일까지 정상 임부와 자간전증임부에서 태어난 신생아 1,243예 및 135예의 체중을 측정하여 그 평균, 백분위수를 산출하고 남녀별 차이를 비교관찰하여 다음과 같은 결론을 얻었다. (단 28주에서 34주사이는 통계적 의의를 찾기 위해 최근 10년간의 신생아를 포함시켰다.) 1. 임신 연령 28주에서 38주까지는 그 증가 양상이 직선을 나타내었고, 그 이후는 완만한 증가양상 을 보였다. 2. 남아와 여아의 체중을 비교하면 60∼3000g정도 남아가 더 무거웠다. 3. 다른 나라와의 신체 표준치를 비교하면 Swedish 보다는 전 임신연령에서 낮은 치를 보였고, Lubchenco의 Denver 미국인이나 Indian 보다 높은 치를 보였다. 4. 자간전증의 경우는 정상임신시 보다 출생체중이 37주 이전에는 230∼350mm 정도의 현저한 체중 감소가 있었으나 38주이후 부터는 40∼140gm 정도의 차이밖에 없었고 37주이전의 자궁내 발육지연 은 38주이후의 2배 정도로 나타났다. The birth weight is as important as the duration of gestation, which have been proved to be valuable evaluating the condition and prognosis of the newborn. Infants falling between 10th and 90th percentile are considered appropriate for gestational age(AGA)_.infants plotting above the 90th percentile are designated large for gestational age(LGA)and those below the 10th percentile are classed small for gestational age(SGA)or growth retarede. These growth retarded infants have not only greater morbidity than the LGA & SGA infants, but also shows retarded physical and mental development. This study was planned to establish the normal range of the birth weight according to gestational age, and it was compared with birth weight of infant born to preeclamptic mothers. The data was based on 1243 cases of newborn infant delivered in Ewha Wonams University Hospital from Januarty to December 1982. The reaslt was as follows; 1. The growth curves of birth weight for the 10th, 50th, 90th, percentill accordint to the gestational age are manifested as straight-line between 28 and 38 weeks of gestation 2. There was no signifcant differences in birth weight of both sex but male infant was relatively heavier than female infant by 60-300gm 3. There was signifcant difference in birth weight between infant born to normotensive and preeclamptic mothers at 36week and 37week although no statistical difference at 38weeks of more 4. In comparison of birth weight curve it appeared tha Korean infants birth weight was generally lighter than Swedishes but heavier than Indians.

일반연제 발표 : 자궁외임신(난관) 진단의 변천 및 그 문제점

홍경희,원규숙,황기현,유한기,강신명 대한산부인과학회 1984 대한산부인과학회 학술대회 Vol.53 No.-

우리나라 1개 농촌 지역 주민의 질병상태에 관한 조사 : 경기도 양주군 수동면

이옥엽,박순복,원규숙,이내숙,등영문 梨花女子大學校 醫科大學 1979 梨花醫學誌 Vol.11 No.-

일반연제 발표 : 난관결찰(卵管結紮)후 속발(續發)된 자궁외임신 및 자궁내임신 11년간 연구

박은희,황기현,원규숙,김종,강신명 대한산부인과학회 1984 대한산부인과학회 학술대회 Vol.53 No.-

우리나라 1개 농촌 지역 주민의 질병상태에 관한 조사 : 경기도 양주군 수동면 Su-Dong Myun, Yang-Ju Gun, Kyung-Gi Do

이옥엽,박순복,원규숙,이내숙,등영문 이화여자대학교 의과대학 1979 梨花醫學誌 Vol.- No.11

A study on the status of disease in a Korean rural Community, Su-Dong Myun, Yong Ju Gun, Kyung-Gi Do was carried out from December, 28 1978 to January, 19 1979 through analizing the meclical records of Su-Dong Health Subcenter during the period september, 1977 to August, 1978 and following results were obtained. 1. New cases of out patients were 5,695 composed of 49.1% male and 50.9% female during the study period. 2. Cumulative cases of out patients were 9,956 composed of 56.4% male and 43.6% female during the study period. 3. Annual morbidity rate was 908.6 per 1,000 for male and 986.4 for female and average annual morbidity rate was 946.6 per 1,00 population. 4. The highest morbidity rate was 3,660.0 as composed of aged 0∼4, the lowest was 498.4 as composed of aged 10∼14 per 1m000 population per year. 5. Following was the order of five major disease which were classified with I.C.D. ① Diseases of the respiratory system : 33.4% ② Diseases of the digestive system : 21.5% ③ Diseases of the skin and subcutaneous tissue : 15.4% ④ Diseases of the nervous system and sense organs : 7.9% ⑤ Accidents, poisonings and violence : 9.4% 6. The visiting rate in the health subcenter were 2.01 for male, 1.44 for female and the average 1.75 per each out patient. 7. Average medical fee per new case was 653±510 won and average cumulatived fee per case was 923±833 won. 8. The distribution of out patients according to the cost of medical fee, 48.9% of total new patients was treated with less than 500 won and 93.3% of new patients was treated with less than 1,000 won.

우리나라 1개 농촌 지역 주민의 질병상태에 관한 조사 : 경기도 양주군 수동면 , Su-Dong Myun, Yang-Ju Gun, Kyung-Gi Do

이옥엽,박순복,원규숙,이내숙,등영문 이화여자대학교 의학회 1979 梨花醫學會誌 Vol.- No.11

A study on the status of disease in a Korean rural Community, Su-Dong Myun, Yong Ju Gun, Kyung-Gi Do was carried out from December, 28 1978 to January, 19 1979 through analizing the meclical records of Su-Dong Health Subcenter during the period september, 1977 to August, 1978 and following results were obtained. 1. New cases of out patients were 5,695 composed of 49.1% male and 50.9% female during the study period. 2. Cumulative cases of out patients were 9,956 composed of 56.4% male and 43.6% female during the study period. 3. Annual morbidity rate was 908.6 per 1,000 for male and 986.4 for female and average annual morbidity rate was 946.6 per 1,00 population. 4. The highest morbidity rate was 3,660.0 as composed of aged 0∼4, the lowest was 498.4 as composed of aged 10∼14 per 1m000 population per year. 5. Following was the order of five major disease which were classified with I.C.D. ① Diseases of the respiratory system : 33.4% ② Diseases of the digestive system : 21.5% ③ Diseases of the skin and subcutaneous tissue : 15.4% ④ Diseases of the nervous system and sense organs : 7.9% ⑤ Accidents, poisonings and violence : 9.4% 6. The visiting rate in the health subcenter were 2.01 for male, 1.44 for female and the average 1.75 per each out patient. 7. Average medical fee per new case was 653±510 won and average cumulatived fee per case was 923±833 won. 8. The distribution of out patients according to the cost of medical fee, 48.9% of total new patients was treated with less than 500 won and 93.3% of new patients was treated with less than 1,000 won.