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Rhodium ( Ⅱ ) 2 ( Propionate ) 2 L4 가 Ehrlich 암세포 분열에 미치는 영향
장일무,우원식 ( Il Moo Chang,Won Sick Woo ) 생화학분자생물학회 1976 BMB Reports Vol.9 No.3
Rhodium(II)₂ (propionte)₄ L₂ is one of few metalic compounds to exhibit antitumor activity against murine tumors. It was demonstrated that 2.7 ㎎/㎏ of rhodium (II)₂ (propionate)₄ L₂ inhibited DNA synthesis of Ehrlich tumor cells in vivo, whereas 0.3㎎/㎏ of this ccmpound did not. Autoradiographic studies indicated that rhodium(II)₂ (propionate)₄L₂ caused disruption of the cyclic pattern of Ehrlich tumor cell replication. It was observed that rhodium(II)₂ propionate₄L₂ exhibited marked reduction in mitotic indices of Ehrlich tumor cells. Ehrlich tumor cells in G₂ phase appeared to be sensitive to rhodium (II)₂ (propionate)₄ L₂.
박재갑,현진원,임경화,신진이,원용진,이영득,신국현,장일무,우원식,Park, Jae-Gahb,Hyun, Jin-Won,Lim, Kyoung-Hwa,Shin, Jin-E,Won, Yong-Jin,Yi, Young-Deuk,Shin, Kuk-Hyun,Chang, Il-Moo,Woo, Won-Sick 한국생약학회 1993 생약학회지 Vol.24 No.3
Antineoplastic activity against human gastric, colon and hepatocellular carcinoma cell lines were measured in 100 extracts from 80 medicinal plants using MTT (3-[4, 5-dimethyl thiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) method. Seventeen extracts from fourteen plants, all of which have previously been reported to have antineoplastic effect, had $IC_{50}$(50% inhibitory concentration) values of less than $230{\;}{\mu}g/ml$ in at least one of the three cell lines. Extracts from remaining sixty-six medicinal plants failed to show significant cytotoxic effect at the concentration of less than $230{\;}{\mu}g/ml$.
현진원,임경화,신진이,성민숙,원용진,김영식,강삼식,장일무,우원식,백우현,김형자,우은란,박호군,박재갑,Hyun, Jin-Won,Lim, Kyoung-Hwa,Shin, Jin-E,Sung, Min-Sook,Won, Yong-Jin,Kim, Yeong-Shik,Kang, Sam-Sik,Chang, Il-Moo,Woo, Won-Sick,Paik, Woo-Hyun 한국생약학회 1994 생약학회지 Vol.25 No.2
Antineoplastic activity against human gastric and colon carcinoma cell lines was measured in 100 extracts from 90 plants using MTT (3-[4,5-dimethyl thiazo-2-yl]-2, 5-diphenyl tetrazolium bromide) method. Four extracts from four plants have been reported to have antineoplastic effect. Extracts from remaining 86 plants failed to show significant cytotoxic effect at the concentration of less than $230\;{\mu}/ml$.