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시신경 유두부 주위에 국한된 양안 망막 포도송이 혈관종 1예
우영준,이윤하,윤이나.Young Jun Woo. MD. Yoon Ha Lee. MD. Ie Na Yoon. MD 대한안과학회 2011 대한안과학회지 Vol.52 No.11
Purpose: The authors of the present case report observed a bilateral retinal racemose hemangioma which was located within the peripapillary area. Case summary: A 17-year-old man presented with floaters in both eyes. Fundus revealed tortuous and anastomosed retinal vasculature around the optic disc. In addition, fluorescein angiography showed a non-leaking retinal arteriovenous anastomosis. Seven years after the initial visit, vitreous hemorrhage occurred in the patient’s left eye, and then 1 year later, subretinal hemorrhage was found in his left eye. Conclusions: Because retinal racemose hemangioma can accompany vitreous hemorrhage and subretinal hemorrhage regardless of size, a routine periodic ophthalmic examination is recommended. J Korean Ophthalmol Soc 2011;52(11):1381-1384
우영준,김지업,나상훈,이종혁,Young Jun Woo,Ji Eob Kim,Sang Hoon Rah,Jong Hyuck Lee 대한안과학회 2012 대한안과학회지 Vol.53 No.9
Purpose: To evaluate the effects of psychosocial stress on intraocular pressure and lacrimal secretion. Methods: Twenty normal adult volunteers (40 eyes) who had no history of systemic or ocular disease such as dry eye syndrome or glaucoma were recruited from clinical research participants. Heart rate, intraocular pressure and lacrimal secretion were measured after the Trier Social Stress Test (TSST) which induces psychosocial stress. The same measurements were taken 1 week later and the recorded measurements were considered as the control group. Results: Heart rate was elevated significantly after the TSST, indicating psychosocial stress was induced by the TSST. Compared to stress resolution status, intraocular pressure and lacrimal secretion were increased after the TSST (p = 0.027, p = 0.011). Elevation of intraocular pressure and lacrimal secretion was statistically significant in males (p = 0.031, p = 0.007), but not significant in females (p = 0.336, p = 0.554). Conclusions: Psychosocial stress can increase intraocular pressure and lacrimal secretion. J Korean Ophthalmol Soc 2012;53(9):1304-1310
전기와 미녹시딜 복합 자극을 통한 인간 모유두세포의 성장 촉진 상승효과
우영준 ( Young Jun Woo ),정관호 ( Kwan Ho Jeong ),김정은 ( Jung Eun Kim ),강훈 ( Hoon Kang ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.5
Background: Previous published clinical studies have demonstrated the positive effects of electrical stimulation (ES) on hair growth. Minoxidil (MXD) enhances hair growth by prolonging the anagen phase of hair follicles. MXD is used to promote hair growth in androgenetic alopecia. Objective: To investigate the combined effect of ES and MXD on cultured human dermal papilla cells (hDPCs). Methods: hDPCs were electrically stimulated with different parameter settings of alternating current. Electrically stimulated hDPCs were incubated in an MXD medium, after which cell proliferation was measured using an MTT assay. Ki-67 and β-catenin expressions were measured by immunofluorescence assay. In addition, Wnt/β-catenin pathway-related gene expressions were measured by real time-PCR, and phosphorylated ERK and AKT protein levels were measured by western blot assay. Results: The combination of 8 V-1 MHz ES and MXD treatment promoted hDPC proliferation effectively, compared with that in the control, ES alone, or MXD alone treatment groups. The immunofluorescence assay showed that the expression of Ki-67 and β-catenin significantly increased in the combined treatment group. Most of the Wnt/β-catenin pathway-related gene expressions increased more with combined treatment than with the control, ES alone, or MXD alone treatments. However, there were no significant differences in the expression levels of phosphorylated ERK and AKT among the treatment groups. Conclusion: ES combined with MXD treatment had a synergistic effect on the proliferation of hDPCs. This might be through the synergistic activation of the Wnt/β-catenin pathway. (Korean J Dermatol 2016;54(5):341∼349)
미녹시딜 도포로 호전을 보인 청소년기 여아에서 발생한 안드로겐 탈모증 1예
우영준 ( Young Jun Woo ),김윤섭 ( Yoon Seob Kim ),김정은 ( Jung Eun Kim ),강훈 ( Hoon Kang ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.1
Androgenetic alopecia (AGA) is a common form of hair loss that usually occurs in the third or fourth decades of life in men, with later onset in women. AGA does rarely occur, however, in the pediatric population. Adolescent AGA is pattern hair loss occurring in boys and girls between 12 and 18 years of age. We herein report the case of a 16-year-old girl with a 5-year history of diffuse hair loss on the crown. Her father had a history of AGA, and the hair pull test was negative. Sex hormone levels and thyroid function test were within the normal range. Phototrichogram analysis revealed diffuse hair thinning over the frontal and vertex areas, and the percentage of vellus hair was higher on the vertex than the occiput. We diagnosed the patient with adolescent AGA. She was prescribed 3% topical minoxidil, and improvement was visible on the clinical photograph and phototrichogram after 2 years of treatment. (Korean J Dermatol 2017;55(1):52∼55)