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사람 외안근에서의 Myosin Heavy Chain 아형의 분포
박경아,오세열,Kyung-Ah Park,MD,Sei Yeul Oh,MD 대한안과학회 2009 대한안과학회지 Vol.50 No.2
Purpose: To provide quantitative data on the distribution of MyHCeom and compare the proportion of myosin heavy chain (MyHC) isoforms between the central and peripheral regions of human extraocular muscles (EOMs). Methods: Medial rectus, lateral rectus, superior rectus, inferior rectus, superior oblique, and inferior oblique muscle samples were taken from three men with brain death. To examine the longitudinal distribution of myosin isoforms, the muscles were divided into central and peripheral portions of equal length. Electrophoresis and densitometry were used to quantify the distribution of MyHC isoforms. Results: Electrophoresis of whole‐muscle extracts of sampled EOMs revealed four MyHC bands that were identified as MyHCI, MyHCeom, MyHCIIa, and MyHCIIx. The proportion of MyHCeom was higher in the central region, whereas the proportion of MyHCIIa was higher in the peripheral region. The relative proportions of MyHCI, MyHCeom, and MyHCIIa were not significantly different among the EOMs. There was a tendency for higher levels of MyHCIIx in the inferior rectus muscle. Conclusions: The proportion of MyHCeom was higher in the central region of human EOMs. Further studies are needed to investigate the consequences of this distributional difference on the function of EOMs.
굴절조절내사시 환자에서 안경 착용을 시작한 연령이 굴절력 변화에 미치는 영향
박경아,김선아,오세열,Kyung-Ah Park,MD,Sun,Ah Kim,MD,Sei Yeul Oh,MD 대한안과학회 2009 대한안과학회지 Vol.50 No.2
Purpose: To evaluate the effect of age wearing prescription glasses on changes in refractive error in accommodative esotropia Methods: We retrospectively reviewed the charts of 63 patients with accommodative esotropia. The patients were divided into three groups according to their age when glasses were prescribed. Changes of the refractive error between the three groups were compared. Results: The mean age at the first visit was 4.1±2.0 years and the mean follow‐up period was 5.7±2.7 years. In children that began wearing glasses before two years of age, the spherical equivalent (SE) refractive error initially increased, peaked 2.5 years after starting to wear glasses, and slowly decreased thereafter. In children who started wearing glasses after two years but not before four years of age the SE refractive error increased and peaked 1.5 years after starting to wear glasses. For children who began wearing glasses after four years of age the SE refractive error increased and peaked after one year. Changes in the refractive error in the youngest age group were significantly different from the other two groups (p=0.064). Conclusions: The age when glasses are prescribed may influence normal emmetropization in accommodative esotropia. However, further studies with longer follow‐ups will be needed to determine the effect of wearing glasses on the final SE refractive error.
이연희,황정민,오세열,Yeon Hee Lee,M,D,Jeong Min Hwang,M,D,Sei Yeul Oh,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.12
Purpose: This study investigated the natural course of strabismus associated with thyroid ophthalmopathy. Methods: A retrospective review was performed on the medical records of 31 patients with strabismus associated with thyroid ophthalmopathy who had been followed up for more than 6 months and had not received surgery. For the purpose of this study, a significant change of deviation angle was defined as more than 10 prism diopters in the primary position. Results: Forty-two percent of patients showed a significant change in deviation angle during the observation period of 23.8±17.7 months. The direction of the change was vertical in 32%, horizontal in 3%, and vertical and horizontal in 6% of patients. A significant change of deviation angle developed in 30% of patients within 6 months from the initial ophthalmologic examination, in 24% between 6 and 12 months, and in 13% of patients between 12 and 18 months from the initial examination. Conclusions: Although the deviation angle of strabismus associated with thyroid ophthalmopathy tended to stabilize with time, it nonetheless was susceptible to change even 12 months after the initial ophthalmologic examination. In addition, a vertical change in the deviation angle was more frequent than a horizontal change
전찬,사호석,오세열,Chan Jeon,Ho Seok Sa,Sei Yeul Oh 대한안과학회 2006 대한안과학회지 Vol.47 No.11
Purpose: To evaluate the causes and natural course of sixth nerve palsy. Methods: The records of 37 patients with the sixth nerve palsy were reviewed to analyze the age of onset, etiology, angle of deviation, natural course of the palsy, and percentage of intervention. Results: The mean age of onset was 38.3 (3~77) years old. Causes and associations were: head trauma (n=11, 30%), idiopathic cause (n=9, 24%), neoplasm (n=7, 19%), aneurysm (n=2, 5%), and others (n=8, 22%). Complete recovery was observed in 80% of patients with nonhemorrhagic trauma and 33.3% with hemorrhagic trauma; 78% of patients with idiopathic cause; and 42.9% of patients with neoplasm. Conclusions: Head trauma was the most common cause of the sixth nerve palsy. Spontaneous complete recovery was observed in 80% of nonhemorrhagic trauma and 78% of idiopathic cases.