새로운 진단적 접근법 : Research Domain Criteria(RDoC)의 소개

오대영,Oh, Daeyoung 대한생물정신의학회 2013 생물정신의학 Vol.20 No.3

The new edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) is published by the American Psychiatric Association. The diagnostic systems for mental disorders have come under criticism for relying on presenting signs and symptoms with the result that they do not adequately reflect relevant neurobiological and behavioral systems. Finally, the National Institute of Mental Health (NIMH) in the United States has suggested the Research Domain Criteria (RDoC) to develop a research classification system based upon dimensions of neurobiology and behavioral aspect. The present review introduces the RDoC as a new reaseach framework.

케타민의 빠른 항우울효과

오대영,Oh, Daeyoung 대한생물정신의학회 2013 생물정신의학 Vol.20 No.2

First-line therapy of depression is a pharmacological treatment. Many prescribed antidepressants modulate monoamine neurotransmitters including serotonin, norepinephrine and dopamine. Recently, Ketamine, an N-methyl-D-aspartate receptor antagonist, has received attention and has been investigated for clinical trials and neurobiological studies. Here, I introduce ketamine as a rapid-acting antidepressant.

Epigenetics와 정신장애

오대영,양병환,이유상,Oh, Daeyoung,Yang, Byung-Hwan,Lee, Yu-Sang 대한생물정신의학회 2008 생물정신의학 Vol.15 No.4

In the post-genomic era, the mechanisms controlling activation of genes are thought to be more important. Gene-environment interactions are crucial in both development and treatment of psychiatric disorders as they are complex genetic disorders. Epigenetics is defined as a change of gene expression that occurs without a change of DNA sequence and can be heritable by certain mechanisms. Epigenetic changes play essential roles in control of gene activation. DNA methylation, chromatin remodeling and RNAi act as key mechanisms for epigenetic modifications of genes. Here, we review the basic mechanisms of epigenetics and discuss their potential involvement of human diseases, including psychiatric disorders.

AMPA 수용체의 조절이 지니는 정신과적 의의

오대영,이은이,Oh, Daeyoung,Lee, Eunee 대한생물정신의학회 2013 생물정신의학 Vol.20 No.1

Glutamate receptors are important components of synaptic transmission in the nervous system. Especially, ${\alpha}$-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate most abundant excitatory synaptic transmission in the brain. There is elaborate mechanism of regulation of AMPA receptors including protein synthesis/degradation, intracellular trafficking, exocytosis/endocytosis and protein modification. In recent studies, it is revealed that functional dysregulation of AMPA receptors are related to major psychiatric disorders. In this review, we describe the structure and function of AMPA receptors in the synapse. We will introduce three steps of mechanism involving trafficking of AMPA receptors to neuronal membrane, lateral diffusion into synapses and synaptic retention by membrane proteins and postsynaptic scaffold proteins. Lastly, we will describe recent studies showing that regulation of AMPA receptors is important pathophysiological mechanism in psychiatric disorders.

시냅스 접착 단백질과 구조 단백질의 정신과적 의의

오대영,Oh, Daeyoung 대한생물정신의학회 2010 생물정신의학 Vol.17 No.3

Synaptic adhesion molecules mediate synapse formation, maturation and maintenance. These proteins are localized at synaptic sites in neuronal axons and dendrites. These proteins function as a bridge of synaptic cleft via interaction with another synaptic adhesion molecules in the opposite side. They can interact with scaffold proteins via intracellular domain and recruit many synaptic proteins, signaling proteins and synaptic vesicles. Scaffold proteins function as a platform in dendritic spines or axonal terminals. Recently, many genetic studies have revealed that synaptic adhesion molecules and scaffold proteins are important in neurodevelopmental disorders, psychotic disorders, mood disorders and anxiety disorders. In this review, fundamental mechanisms of synapse formation and maturation related with synaptic adhesion molecules and scaffold proteins are introduced and their psychiatric implications addressed.

지능형 스마트 TV 응용을 위한 BGOLAM 기반의 성별분류

오대영(Oh, Daeyoung),최지원(Choi, Jiwon),김창익(Kim, Changick) 한국방송·미디어공학회 2011 한국방송공학회 학술발표대회 논문집 Vol.2011 No.7

최근 스마트폰, 태블릿 PC와 같은 모바일 스마트 디바이스(mobile smart devices)와 더불어 스마트 TV에 대한 관심이 크게 증가하면서 사용자들의 컨텐츠와 기능에 대한 요구 또한 다양해지고 있다. 스마트 TV가 컨텐츠와 기능적 측면에서 사용자의 편의와 재미, 그리고 유익함을 동시에 만족시키기 위해서는 더욱 지능화된 기능을 탑재할 필요가 있다. 일반적으로 남녀에 따라 TV를 시청하는 경향이 다르기 때문에 현재 TV를 시청하는 사용자의 성별분류(gender classification)를 통해 성별에 따른 따른 채널이나 광고, 응용 프로그램을 달리 제공하는 성별 기반의 스마트 TV 응용을 개발할 수 있게 된다. 본 논문에서는 스마트 TV 응용에 적합한 BGOLAM 기반의 성별분류 방법에 대해 제안하고, 실험을 통해 제안하는 방법의 적절성을 보인다

고로슬래그 콘크리트의 투수특성에 관한 실험적 연구

백신원,오대영,Paik, Shinwon,Oh, Daeyoung 한국농공학회 2013 한국농공학회논문집 Vol.55 No.3

The pavement is generally used on the highways, local loads, roads for bicycle riding and neighborhood living facility such as parking lot, plaza, park and sports facilities. However, the pavement material that is usually used on the most of roads is impermeable asphalt-concrete and cement-concrete. If the pavement material is impermeable, many problems can be happened on the drainage facilities in the rainy season. Additionally, a lot of rainwater on the pavement surface cannot permeate to the underground and flows to the sewage ditch, stream and river, etc. If a lot of rainwater flows at once, the floods can be out along the streams and rivers. So, underground water can be exhausted. Micro organisms cannot live in the underground. Recently, many studies has been conducted to exploit the permeable concrete that has high performance permeability. However, it is required to develop the permeable concrete which has high strength and durability. In this study, permeable and strength tests were performed to investigate the permeable characteristics of porous concrete according to fine aggregate content and substitution ratio of blast furnace slag. In this test, crushed stones with 10~20 mm and sand with 5~10 mm were used as a coarse aggregate and a fine aggregate respectively. The substitution ratio of blast furnace slag to cement weight is 0 %, 15 %, and 30 %. The ratio of fine aggregate to total aggregate is 0 %, 18 %, and 35 %. As a result, permeability coefficient was decreased according to fine aggregate ratio of total aggregate. Compressive strength was also decreased according to substitution ratio of blast furnace slag.

범불안장애 환자와 일반인의 걱정 내용 및 심각도의 비교

김휘곤,김대호,오대영,서호준,허휴정,채정호,Kim, Hwigon,Kim, Daeho,Oh, Daeyoung,Seo, Ho Jun,Huh, Hyu Jung,Chae, Jeong Ho 대한불안의학회 2015 대한불안의학회지 Vol.11 No.1

Objective : Generalized anxiety disorder (GAD) is a common anxiety disorder characterized by excessive worries and anxiety symptoms. To distinguish between pathological and normal worries, this study compared the contents and severity of worries among patients with GAD with those of matched non-psychiatric control Methods : Thirty outpatients with GAD receiving treatment at the psychiatric department of Hanyang University Guri Hospital were recruited. As a matched control group, we selected 30 adults without psychiatric history who participated in the Anxiety Disorder Survey, during the Mental Health Exposition held in Seoul in April, 2014. Matched demographic data were age, sex, education, and household income. Self-questionnaires included demographic data, contents of worry (10 categories of worries and each severity), and the Pennsylvania State Worry Questionnaire (PSWQ). Results : There was no statistical difference in the contents of worry between patient and control groups. However, the total PSWQ scores significantly higher in the GAD group. Conclusion : Our findings suggest that patients and non-patients worry about the similar contents and worries in GAD cannot be differentiated by what people worry about. Only the severity of worry was a distinguishable feature. Our finding supported inclusion of the diagnostic criterion of "excesslve wornes" in GAD.

SNS Map : 위치 기반 SNS 데이터 맵핑 시스템

이승훈(Seunghun Lee),오대영(Daeyoung Oh),강민혁(Minhyuk Kang),김현철(Hyunchul Kim) 한국정보과학회 2015 한국정보과학회 학술발표논문집 Vol.2015 No.6

몰입형 화상 회의를 위한 강건한 객체 추출 방법

안일구(Ilkoo Ahn),오대영(Daeyoung Oh),김재광(Jaekwang Kim),김창익(Changick Kim) 大韓電子工學會 2011 電子工學會論文誌-SP (Signal processing) Vol.48 No.2

본 논문에서 우리는 실시간 성능이 요구되는 비디오 화상회의 시스템을 위해 사전정보 없이 정확하면서도 완전히 자동으로 비디오 객체를 추출하는 방법을 제안한다. 제안하는 방법은 두 단계로 이루어진다: 1) 초기 프레임에서의 정확한 객체 추출, 2) 객체 추출 결과를 이용한 그 이후 프레임에서의 실시간 객체 추출. 초기 프레임에서의 객체 추출은 초기 프레임들의 차영상으로부터 구한 에지들을 누적시킨 누적 에지맵 생성으로부터 시작된다. 즉, 객체의 초기 움직임의 누적으로부터 객체의 형상을 추측하고자 하는 것이다. 이 추측된 형상은 그래프 컷(Graph-Cut) 영상 분할을 위한 객체 씨드(seeds)와 배경 씨드를 할당하는데 이용된다. 그래프 컷 기반 객체 추출 이후 프레임부터는 객체 추출 결과와 연속된 프레임의 차영상의 에지맵을 이용하여 실시간 객체 추출이 수행된다. 실험결과를 통해 제안하는 방법이 이전 연구들과 달리 VGA 크기의 비디오에 대해서도 실시간으로 동작함을 보이고, 따라서 몰입적인 비디오 화상회의 시스템의 개발을 위한 유용한 도구임을 보이고자 한다. In this paper, an accurate and fully automatic video object segmentation method is proposed for video conferencing systems in which the real-time performance is required. The proposed method consists of two steps: 1) accurate object extraction on the initial frame, 2) real-time object extraction from the next frame using the result of the first step. Object extraction on the initial frame starts with generating a cumulative edge map obtained from frame differences in the beginning. This is because we can estimate the initial shape of the foreground object from the cumulative motion. This estimated shape is used to assign the seeds for both object and background, which are needed for Graph-Cut segmentation. Once the foreground object is extracted by Graph-Cut segmentation, real-time object extraction is conducted using the extracted object and the double edge map obtained from the difference between two successive frames. Experimental results show that the proposed method is suitable for real-time processing even in VGA resolution videos contrary to previous methods, being a useful tool for immersive video conferencing systems.