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Omeprazole-cholestyramine Resin 제제의 인체에 대한 약물동력학적 연구
이영욱,우종수,이태상,염지현,강희윤,신창열,손의동,허인회 중앙대학교 약학연구소 2000 약학 논총 Vol.14 No.-
We have performed the pharmacokinetic study of omeprazole- cholestyramine resinate, which has been developed to increase the stability of omeprazole, the well-known proton pump inhibitor, in an acidic condition. In the human experiments, AUC or T_max of oral administration of omeprazole-cholestyramine resinate is bioequivalent with omeprazole, but C_max was 20% higher in omeprazole-cholestyramine resinate than omeprazole. Omeprazole-cholestyramine resinate suppository showed higher C_max and shortened T_max, so it is expected to show a rapid absorption. These data suggest that omeprazole-cholestyramine resinate is more stable in acid and more rapidly absorbed than omeprazole.