자폐스펙트럼장애에서의 수면문제

양영희,김지훈,이진성,Yang, Young-Hui,Kim, Ji-Hoon,Lee, Jin-Seong 대한수면의학회 2013 수면·정신생리 Vol.20 No.2

Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restricted, repetitive patterns of behavior and interest. Sleep problems are not uncommon in children with autism spectrum disorders. Symptoms of insomnia are the most frequent sleep problems in individuals with ASD. Sleep problems can cause significant difficulties in the daily life of children with ASD and their families. Genetic factor, deregulations of melatonin synthesis, extraneous environmental stimuli and psychiatric and medical conditions may cause sleep problems. The first line treatment of sleep problems in ASD includes managements for potential contributing factors and parent education about sleep hygiene care for child and behavioral therapy. Supplementation with melatonin may be effective before considering other medications, such as risperidone, clonidine, and mirtazapine.

주의력결핍 과잉행동장애에서 정신자극제를 이용한 약물치료

양영희(Young Hui Yang),유희정(Hee Jeong Yoo) 대한소아청소년정신의학회 2008 소아청소년정신의학 Vol.19 No.2

Attention-deficit hyperactivity disorder (ADHD) is characterized by inattention, hyperactivity, impulsiveness and problems in other higher cognitive processes such as executive function deficits. Currently, there are many treatment modalities, of which pharmacotherapy is the most strongly supported by scientific and clinical evidence. Stimulants, which are first choice in the pharmacological treatment of ADHD, block dopamine reuptake by binding the dopamine transporter and so increasing the concentration of dopamine in synaptic clefts. Stimulants are effective in improving core ADHD symptoms, as well as the nonspecific symptoms, such as aggressiveness and oppositional behavior. Frequently reported short-term adverse effects are decreased appetite, sleep disturbance, headache, dizziness and irritability. Although questions have been raised about the long-term side effects of stimulants, including growth suppression, cardiovascular events, and abuse potential, there is no clear evidence to support these concerns.

주의력결핍 과잉행동장애 아동에서 Osmotic-Controlled Release Oral Delivery System Methylphenidate 투여가 국소 대뇌관류에 미치는 영향

양영희(Young-Hui Yang),황준원(Jun-Won Hwang),김붕년(Boong-Nyun Kim),강혜진(Hyejin Kang),이재성(Jae-Sung Lee),이동수(Dong-Soo Lee),조수철(Soo-Churl Cho) 대한소아청소년정신의학회 2016 소아청소년정신의학 Vol.27 No.1

Objectives: The objective of this study was to examine the effects of osmotic-controlled release oral delivery system methylphenidate on changes in regional cerebral blood flow (rCBF) in children with attention-deficit hyperactivity disorder (ADHD) using single photon emission computed tomography (SPECT). Methods: A total of 26 children with ADHD (21 boys, mean age: 9.2±2.05 years old) were recruited. Each ADHD participant was examined for changes in rCBF using technetium-99m-hexamethylpropylene amine oxime brain SPECT before and after 8 weeks methylphenidate medication. Brain SPECT images of pediatric normal controls were selected retrospectively. SPECT images of ADHD children taken before medication were compared with those of pediatric normal controls and those taken after medication using statistical parametric mapping analysis on a voxel-wise basis. Results: Before methylphenidate medication, significantly decreased rCBF in the cerebellum and increased rCBF in the right precuneus, left anterior cingulate, right postcentral gyrus, right inferior parietal lobule and right precentral gyrus were observed in ADHD children compared to pediatric normal controls (p-value<.0005, uncorrected). After medication, we observed significant hypoperfusion in the left thalamus and left cerebellum compared to pediatric normal controls (p-value<.0005, uncorrected). In the comparison between before medication and after medication, there was significant hyperperfusion in the superior frontal gyrus and middle frontal gyrus and significant hypoperfusion in the right insula, right caudate, right middle frontal gyrus, left subcallosal gyrus, left claustrum, and left superior temporal gyrus after methylphenidate medication (p-value<.0005, uncorrected). Conclusion: This study supports dysfunctions of fronto-striatal structures and cerebellum in ADHD. We suggest that methylphenidate may have some effects on the frontal lobe, parietal lobe, and cerebellum in children with ADHD.

공격적 문제행동을 보이는 자폐스펙트럼장애 아동청소년의 임상적 특징

양영희(Young-Hui Yang),김현정(Hyen-Jung Kim),이원혜(Won-Hye Lee) 대한소아청소년정신의학회 2017 소아청소년정신의학 Vol.28 No.4

Objectives: The aim of this study was to investigate the clinical characteristics of aggressive behavior problems in children and adolescents with autism spectrum disorder (ASD). Methods: Children and adolescents with ASD, aged 6–18 years, were included in this study. We divided them into two groups according to the presence or absence of aggressive behavior. They were assessed using three scales, the Korean-Child Behavior Checklist (K-CBCL), Behavior Problem Inventory, and Social Communication Questionnaire, which were completed by their parents, who conducted a continuous performance test to evaluate their attention function. The statistical analysis was done using the Mann-Whitney U-test between the two groups at a p-value of 0.05. Results: A total of 17 children participated in this study. Ten children (7 boys, 12.4±4.27 years) were included in the group with aggressive behavior problems and 7 children (6 boys, 13.8±3.53 years) in the group without aggressive behavior problems. There were no significant differences in the age, gender or intelligence quotient of the two groups. The children with aggressive behavior problems showed a trend of higher T-scores in the attention problems and anxiety/depressed subscale of the CBLC (p<0.1). Conclusion: The results suggest that aggressive behavior problems in children with ASD may be related to their attention problems, anxiety and depression.

대한소아청소년정신의학회 의료윤리규정 : 왜 필요한가?

구영진(Young-Jin Koo),황준원(Jun-Won Hwang),이문수(Moon-Soo Lee),양영희(Young-Hui Yang),방수영(Soo-Young Bang),강제욱(Je-Wook Kang),이대환(Dae-Hwan Lee),이주현(Ju-Hyun Lee),곽영숙(Young-Sook Kwack),김승태(Seungtai Peter Kim),노경선(K 대한소아청소년정신의학회 2016 소아청소년정신의학 Vol.27 No.1

This article provides an overview of the developmental history and rationale of medical ethics to establish the code of ethics and professional conduct of the Korean Academy of Child and Adolescent Psychiatry (KACAP). Most medical professional organizations have their own codes of ethics and conduct because they have continuous responsibility to regulate professional activities and conducts for their members. The Ethics and Award Committee of the KACAP appointed a Task-Force to establish the code of ethics and conduct in 2012. Because bioethics has become global, the Ethics Task Force examined global standards. Global standards in medical ethics and professional conduct adopted by the World Medical Association and the World Psychiatric Association have provided the basic framework for our KACAP’s code of ethics and professional conduct. The Code of Ethics of the Americal Academy of Child and Adolescent Psychiatry has provided us additional specific clarifications required for child and adolescent patients. The code of ethics and professional conduct of the KACAP will be helpful to us in ethical clinical practice and will ensure our competence in recognizing ethical violations.

의학전문대학원 학생들의 수면과 심리적 요인

김대욱,김성곤,김지훈,양영희,정우영,이진성,Kim, Dae-Wook,Kim, Sung-Gon,Kim, Ji-Hoon,Yang, Young-Hui,Jung, Woo-Young,Lee, Jin-Seong 대한수면의학회 2013 수면·정신생리 Vol.20 No.2

목 적 : 의학전문대학원 학생들은 과도한 학업으로 인해 수면 시간이 부족하고 수면의 질이 낮다고 알려져 있다. 본 연구는 의학전문대학원 학생의 수면 양상 및 이와 연관이 있을 것으로 생각되는 심리적 문제를 조사하였다. 방 법 : 부산대학교 의학전문대학원 1~4학년 학생 352명을 대상으로 수면 양상, Pittsburgh sleep quality index(PSQI), Epworth sleepiness scale(ESS), global assessment of recent stress scale(GASS), the center for epidemiologic studies-depression scale(CES-D), and Moudsley obsessive-compulsive inventory(MOCI)를 조사하였다. 두 군간 연속변수 비교에는 독립 t-검정, 비연속비교는 ${\chi}^2$-검정, 두 변수간의 상관관계는 Pearson 상관분석, 그리고 세 군 이상 비교에는 ANOVA를 이용하였다(p<0.05, 양측검정). 결 과 : 평일 수면시간 5시간 36분, 주말 수면시간 7시간 39분으로, 주말 수면시간이 더 길었다(t=15.94, p<0.001). 취침 시각은 평일 0 : 49, 주말 1 : 34으로 주말에 더 늦게 취침하였고(t=-5.23, p<0.001), 기상 시각은 평일 6 : 58,. 주말 9 : 30으로 주말에 더 늦게 기상하였다(t=-24.48, p<0.001). PSQI는 ESS(r=0.383, p<0.001), GASS(r=0.326, p<0.001), CES-D(r=0.393, p<0.001), 그리고 MOCI 점수(r=0.247, p< 0.001)와 양의 상관관계를 보였지만, 성적과는 상관관계를 보이지 않았다(r=0.072, p=0.228). 학년이 높을수록 PSQI, GASS, CES-D, MOCI 점수가 낮았다(p<0.05). 결 론 : 의학전문대학원생들의 수면의 질은 낮았고 수면 시간은 부족하였다. 수면의 질은 주간졸림, 우울감, 스트레스, 강박 성향과 연관성이 있었다. Introduction: Although it is well known that medical students are not getting an adequate amount of sleep, there have been only a few studies on the sleep patterns of medical students and the related factors. Therefore, the present study aimed to investigate the medical students' sleep patterns and the related factors. Methods: A questionnaire package was administered to the $1^{st}$ to $4^{th}$ year medical students at one medical school. It consisted of questions asking about their lifestyles as well as Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), global assessment of recent stress scale (GASS), the center for epidemiologic studies-depression scale (CES-D), and Moudsley obsessive-compulsive inventory (MOCI). A total of 352 students (206 males and 146 females) responded to the survey and the result was analyzed using the independent t-test, the chi-square test, the paired t-test, Pearson's correlation and ANOVA. p-values of less than 0.05 were considered statistically significant in analyses. Results: The weekend bedtime was significantly delayed (0 : 49 on weekday ; 1 : 34 on weekend ; t=-5.23, p<0.001), the weekend rise time was delayed (6 : 58 on weekday ; 9 : 30 on weekend ; t=-24.48, p<0.001) and the total sleep time was increased on weekends (5 : 36 on weekday ; 7 : 39 on weekend ; t=15.94, p<0.001). The PSQI score of all subjects was 6.43{\pm}2.64. PSQI was positively correlated with ESS (r=0.383, p<0.001), GASS (r=0.326, p<0.001), CES-D (r=0.393, p< 0.001), and MOCI (r=0.247, p<0.001), but not with GPA (r=0.072, p=0.228. The more senior students had lower PSQI, GASS, CES-D, and MOCI score (p<0.05). Conclusion: Medical students were experiencing a lack of sleep during weekdays as they have a later bedtime and earlier rise time, and consequently had more hours of sleep on weekends. Overall, the medical students were experiencing poor sleep quality and sleep deprivation. Poor sleep quality is associated with psychological problems (daytime sleepiness, stress, depression, and obsessive tendency).

수면과 알코올

이진성,김성곤,정우영,양영희,Lee, Jin-Seong,Kim, Sung-Gon,Jung, Woo-Young,Yang, Young-Hui 대한수면의학회 2013 수면·정신생리 Vol.20 No.2

Alcohol has been used as sedatives historically. The effect of alcohol on sleep is different according to its dose, timing of ingestion, and drinking frequency. Sleep problems may play a role in the development and course of alcohol-related disorders. Insomnia in alcohol-dependent patients is common and early treatment of insomnia may reduce the rate of relapse. Sleep apnea, restless legs syndrome, periodic limbs movement disorder, and altered circadian rhythm may be more frequent in this patients. Management of sleep and alcohol problems is important in treating alcohol-related disorder and sleep disorders, respectively.

주의력결핍 과잉행동장애 아동에서 α-2A 아드레날린 수용체 유전자의 MspI 유전자 다형성에 따른 메칠페니데이트 치료 전후 뇌관류 비교

박수빈(Subin Park),배정훈(Jeong-Hoon Bae),김재원(Jae-Won Kim),양영희(Young-Hui Yang),오승민(Seungmin Oh),홍순범(Soon-Beom Hong),박민현(Min-Heyon Park),김붕년(Boong-Nyun Kim),신민섭(Min-Sup Shin),유희정(Hee-Jeong Yoo),조수철(Soo-Churl 대한소아청소년정신의학회 2013 소아청소년정신의학 Vol.24 No.1

Objectives:Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD. Methods:Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated. Results:No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype. Conclusion:Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.

정신질환을 가진 부모의 자녀들의 정신건강 상태 조사 연구

서화연(Hwo Yeon Seo),박수미(Su Mi Park),김예니(Yeni Kim),양영희(Young Hui Yang),이지연(Ji Yeuon Lee),이해우(Hae Woo Lee),정희연(Hee Yeon Jung) 대한소아청소년정신의학회 2017 소아청소년정신의학 Vol.28 No.4

Objectives: This study aimed to evaluate the mental health status of the children of psychiatric patients in order to plan for the resources that may be necessary to help these children achieve their full potential. Methods: Forty-eight children (age 9–18) whose parents were registered in 5 community mental health centers located in Seoul were recruited. Tests assessing 3 psychological domains were conducted: 1) cognition: Korean version of Learning Disability Evaluation Scale, Comprehensive Attention Test, 2) parent reported emotion and behavior: Korean Child Behavior Checklist, Korean attention-deficit hyperactivity disorder Rating Scale, and 3) self-reported emotion and behavior: Korean Beck’s Depression Inventory-II/Children’s Depression Inventory-II, Korean Youth Self Report). We defined the children as having a high risk of developing mental health problems if their test scores were over the cut-off levels in 2 or more of the 3 domains assessed. Results: Twelve (25%) children were classified as having a high risk of developing mental health issues. 20 (41.6%) children scored above the cut-off in only one of the domains. Conclusion: Our results suggest that the children of psychiatric patients might be vulnerable to mental illness and need early prevention or interven-tions for the sake of their mental health.

한국판 문제행동 평가도구(Behavior Problems Inventory-01) 표준화 연구

최미지(Miji Choi),김예니(Yeni Kim),반지정(Ji-Jeong Ban),황석현(Samuel Suk-Hyun Hwang),김붕년(Bung-Nyun Kim),양영희(Young-Hui Yang) 대한소아청소년정신의학회 2017 소아청소년정신의학 Vol.28 No.4

Objectives: The purpose of this study was to examine the reliability and validity of the Korean version of the Behavior Problems Inventory (BPI-01) among children and adolescents aged between 3 and 18. Methods: The control group consisting of one hundred children and adolescents was recruited from schools and the patient group consisting of forty one children and adolescents with autism spectrum disorder were recruited from a hospital. We compared the measurements of both groups. To assess the concurrent validity of the BPI-01, we compared the problem behavior index of the Korean Scale of Independent Behavior-Revised (K-SIB-R) and, to assess the discriminant validity, we compared the Korean version of the Child Behavior Checklist (K-CBCL). The Cronbach’s alpha of the BPI-01 was measured to assess its reliability. Correlation analyses between the BPI-01 and the other scale were carried out to examine the former’s concurrent and discriminant validity. Results: The patient group showed a significantly higher score for all three subscales of the BPI than the control group. The Cronbach’s alpha was 0.92 for the total severity score of the BPI and ranged between 0.67–0.89 for each subscale in the patient group. All subscales of the BPI-01’s, i.e., self injurious behavior, stereotyped behavior and aggressive/destructive behavior, were significantly correlated with the corresponding subscales of the K-SIB-R. The BPI-01 generally did not demonstrate any significant correlation with emotional items such as anxiety/depression in the K-CBCL. Especially, the BPI-01’s stereotyped behavior subscale showed little correlation with externalizing behaviors such as social problems and aggressive behaviors. Conclusion: This study found that the Korean version of BPI-01 is a reliable and valid behavior rating instrument for problem behavior in developmental disabilities among children and adolescents.