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쾌속조형기법을 이용한 생분해성 스텐트용 메쉬필름의 약물방출거동 효과
정신영(Sin Young Cheong),김양은(Yang Eun Kim),고영주(Young Joo Koh),신왕수(Wang Soo Shin),이준희(Jun Hee Lee),김완두(Wan Doo Kim),유영은(Young Eun Yoo),박수아(Su A Park) 한국고분자학회 2014 폴리머 Vol.38 No.1
약물방출 고분자 코팅 스텐트는 수술후 재협착을 획기적으로 줄였지만, 약물방출이 균일한 구조체를 제작하는 것이 어렵고 체내에 구조체를 영구적으로 남겨야 하는 부담을 여전히 가지고 있다. 이를 해결하는 방안으로 생분해성 고분자로 스텐트를 제작하는 방법들이 활발하게 연구되고 있다. 본 연구에서는 조형가공기술(solid freeformfabrication, SFF)의 하나인 쾌속조형기법(rapid prototyping technique)의 3차원 플로팅(3D plotting) 기술을 이용하여파크리탁셀(PTX) 약물을 함유한 폴리카프로락톤(PCL) 3차원 구조체를 제작하였고, 생분해성 PCL 고분자로부터PTX의 방출거동과 스텐트 제작 가능성을 고찰하였다. 약물을 포함한 구조체의 표면특성을 SEM으로 확인한 결과굴곡이 자연스럽고 매끄러운 표면을 가지고 있었다. FTIR을 통해서 약물이 성공적으로 구조체에 포함되었음을 확인하였고, NMR과 HPLC를 통해서 PCL 구조체 중의 PCL함량과 PTX의 서서히 방출됨을 확인되었다. 또한 세포실험을 통해 구조체에서 방출된 약물이 생물학적으로 활성을 유지하고 있으며, 반복제작된 구조체에서도 균일한 활성의 약물이 방출됨을 확인하였다. 이와 같은 쾌속조형기법을 이용하여 약물을 포함하는 구조체를 제작하고 분석함으로써, 생분해성 고분자 스텐트로서의 적용가능성을 제시하였다. Biodegradable drug-eluting stent has dual functions of supporting the lumen and treating internal tumor preventingthe restenosis by releasing drug. In this study, the polycaprolactone (PCL) based three dimensional (3D) meshloaded with paclitaxel (PTX) was presented by rapid prototyping (RP) technique of solid freeform fabrication (SFF) forbiodegradable drug-eluting stent application. PCL has many advantageous properties such as good biocompatibility, goodmechanical properties, and good drug permeability. PTX is widely used in the cancer treatment by inhibiting tumor cellproliferation. Analytical methods of HPLC and NMR were used for simultaneous quantification of PTX. Scanning electronmicroscopy (SEM) was performed to observe the architecture and morphologies of 3D mesh. The cytotoxicity assayresults indicated released PTX`s biological activity. This study provided that PCL based 3D mesh loaded with PTX byRP technique has great potential for biodegradable drug-eluting stent application.
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성인에서 Lidocaine 의 전처치가 Rocuronium 의 근이완 발현 시간에 미치는 효과
신동선,최세진,이미정,안미정,양신영 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.4
The Effect of Lidocaine on the Onset Time of Rocuronium-induced Neuromuscular Blockade in Adults Mi Joung Lee, M.D.^*, Dong Sun Shin, M.D., Mi Jeong Ahn, M.D. ^+ Sin Young Yang, M.D., and Sae Jin Choi, M.D. Department of Anesthesiology, College of Medicine, Chungnam National University, Korea ^*Department of Anesthesiology, College of Medicine, The catholic Univercity of Korea ^↑Department of Anesthesiology, Okchun Sungmo Hospital, Korea Background: Rapid-sequence intubation is a common technique to reduce anesthetic complication. Due to side effects of succinylcholine, nondepolarzing muscle relaxants have been tried. Rocuronium is a new nondepolarizing muscle relaxant with a brief onset of action, but devoid of the adverse reaction associated with succinylcholine. Most local anesthetics decrease neuromuscular transmission and ponten-tiate neuromuscular blocks of muscle relaxants. The purpose of this study was to examine the effect of lidocaline on the onset time of rocuronium-induced neuromuscular blockade in adults. Methods: Fourty five patients, ASA physical status Ⅰ or Ⅱ, were randomly divided into three groups. Anesthetic induction with thiopental 5 mg/kg was made. Succinylcholine (1.0 mg/kg) was administered intravenously in group 1. Rocuronium (0.6 mg/kg) was given in group 2, additional lidocaine (1.0 mg/kg) was given intravenously 1 minute prior to the administration of rocuromium in group 3. Neuromuscular blockade was assessed by train-of-four at the adductor pollicis muscle with supramaximal stimulation of the ulnar nerve (2 Hz, 0.2 msec) every 10 seconds. The condition of intubation, the appearance of arrhythmias, side effects of drugs, and the changes of mean arterial pressure and heart rate were checked and compared in peri-induction periods. Results: The onset time of group 1 (55.1 ?? 14.9 sec) was faster than that of group 2 (137.8 ?? 46.0 sec) and group 3 (139.3 ?? 41.0 sec), but there was no difference between the onset time of group 2 and that of group 3. Intubating conditions were good or excellent in all groups, but group 1 and 3 were better than group 2. There was no difference between the three groups in hemodynamics. More adverse effects were observed in group 1, that of group 2 and 3 were observed in only one case. Conclusions: The authors concluded that licocaine is not effective on the onset time of rocuronium, but improves the intubating condition. Rocuronium is devoid of side effects of succinylcholine, but not a alternative to succinylcholine because its onset time is too slow when compared with succinylcholine. (Korean J Anesthesiol 2001; 41: 407~414)
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정맥내 통증자가조절법을 이용한 Nalbuphine-Ketorolac과 Butorphanol-Ketorolac의 술후 진통효과 비교
윤석화,이원형,손수창,신용섭,김윤희,양신영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
This study aimed to compare analgegic efficacy, satisfaction score and side effect of nalbuphine-ketorolac and butorphanol-ketorolac by using intravenous patient controlled analgesia(IV-PCA) for postoperative anlgesia following a gastrectomy for stomach cancer. Ninety patients who had undergone gastrectomy for stomach cancer under general anesthesia were randomly divided into two groups. Each group recieived nalbuphine 50mg with ketorolac 150mg(Group 1, n=45) and butorphanol 5mg with ketorolac 150mg(Group 2, n=45) by using IV-PCA during postoperative 48hrs. Assessments for pain with numerical rating scale(NRS), and side effects were evaluated at 2hr, 6hr, 12hr, 24hr, 36hr and 48hr after the operation. There were no significant difference in NRS for pain during rest, but Group 2 requested significantly greater amount of supplementary diclofenac during first 24 hours. Side effects were higher Group 1 in pruritus, nausea and vomiting and Group 2 in sedation, nausea and vomiting. This study suggests that adding ketorolac with intravenous nalbuphine or butrophanol in using an intravenous PCA can decrease analgesics requirement and improve analgesic property without the major morbidity like respiratory depression, but needs for the careful observation and treatment on the side effects like nausea. vomiting, pruritis and sedation...
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