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Photocrosslinkable Biopolymers for Enhanced Tissue Adhesion and Local Drug Delivery
Seung Yun Yang(양승윤) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Photocrosslinkable biodegradable polymers have emerged as a new class of biomaterials in tissue adhesion and drug delivery. In part 1 of my talk, I will present in situ photocrosslinkable hyaluronic acid (HA)-based tissue adhesives, providing tunable mechanical properties and firm tissue adhesion under wet and dynamic conditions. Depending on the degree of photocrosslinkable groups, mechanical and adhesive properties were improved. In part 2, I will present a radioactive HA hydrogel microparticles, which can be used for local radiotherapy with minimal off-target biodistribution. The radioactive HA microgels exhibited a prolonged radioactivity kinetics similar to the natural decay of radioisotope, thereby providing long-term and predictable radioactivity. Moreover, using a rat model, we further confirmed the local retention of photocrosslinked HA microgels around the injected site and their high biocompatibility throughout the application period.
수중운동체의 유체계수 추정을 위한 시스템 식별기법 연구
양승윤(Seung-Yun Yang),최중락(Joong-Lak Choi),김홍렬(Heung-Youl Kim) 대한전자공학회 1992 대한전자공학회 학술대회 Vol.1992 No.10
It is necessary to estimate hydrodynamic coefficients to design the auto-pilot system and motion simulator of submersible vehicle. In this paper, an algorithm was designed to estimate hydrodynamic coefficients of submersible vehicle. Using this algorithm, the hydrodynamic coefficients were estimated from measurements of full scale trial. The estimated hydrodynamic coefficients were used for the design of an auto-depth controller(ADC) of submersible vehicle, and the resulting ADC are proved to have a better performance than the previous one.